Artificial Intelligence

When COVID-19 strikes, we learn from the traces 

Leading AI scientist Bogdan Georgescu and his team have developed an algorithm that could greatly benefit clinicians in future by helping them to assess COVID-19 severity and progression.

Andrea Lutz
Published on 11. Februar 2021

Hot on the trail of COVID-19: Working with collaborators from around the world, a team began developing an algorithm that helps to evaluate changes in lung tissue. Read about how scientists reached a significant milestone during the pandemic.

<p>One of the major challenges in radiology is dealing with the large amounts of highly complex data generated during examinations. Comparatively few specialists can evaluate the data, and it is a time-consuming process. As a result, applications using <a href="artificial intelligence (AI)" class="cp-fab-text-highlight">artificial intelligence (AI)</a> are becoming increasingly important. Even today, task-specific AI solutions can help physicians to detect patterns and recognize systematic phenomena in their investigations. </p>

AI is designed to emulate human decision-making structures. So-called “weak AI” addresses specific, concrete tasks, while “strong AI” involves general intelligence similar to that of humans. All systems that currently exist fall into the category of weak AI.

The computer is given a certain task and practices executing it using various examples. The system analyzes the examples in the course of the training, and on this basis develops a model for processing similar data or tasks in the same way in the future. However, AI does not do all this without any preliminary work – it requires a detailed specification of the scientific problem behind the clinical question, proper high-quality data collection and annotation, and good AI algorithm design and training. The real key to AI is human expertise: Experienced clinical radiologists and technicians annotate millions of images before an algorithm is ready for training. Multiple experts use the mouse to click on the images and define, for instance, what pulmonary emphysema or a lung nodule look like. <p><br></p><p>In the case of COVID-19, abnormal regions showing airway disease are localized and delineated in the CT image. Once an abnormal region has been detected in an image, the computer can learn from the examples and apply the extracted concepts to new data. The quality of the annotations and data has a major impact on the quality of the final product. </p>
<p>Bogdan Georgescu is an expert in AI technologies. Working with an international team, he is developing prototype solutions that will speed up the analysis of radiological patterns in the lungs that could be caused by COVID-19.</p>
AI scientist Bogdan Georgescu
In patients with severe COVID-19, a CT scan will enable the detection of lung <a href="abnormalities" class="cp-fab-text-highlight">abnormalities</a>. The extent of these abnormalities seems to be directly related to the severity of the illness. CT imaging can therefore play a significant role in diagnosing COVID-19 because it gives physicians and scientists valuable insights. A CT scan of the chest or thorax not only shows the extent of lung disease, but can also reveal how a patient is responding to various therapies and how their recovery is progressing.

The most common abnormalities are changes to the lung in the form of lung blebs that contain fluid or tissue and prevent gas exchange.

Image of the lung
<p>The world is currently in a state of emergency, with governments everywhere restricting personal contact. However, this does not prevent researchers worldwide from pioneering new methods and developing new ideas. Siemens Healthineers formed an international and interdisciplinary team comprising AI scientists from the U.S., software developers from India, CT product as well as research and development experts from Germany, and medical experts from around the globe – and brought them together around a virtual conference table, all with a common goal.</p>
to develop algorithms. That is why our supercomputer "Sherlock" runs at 24,000,000,000,000 floating point operations per second.
Supercomputer "Sherlock"
In February 2020, SARS-CoV-2 spread like wildfire around the world. In the very early days of the pandemic, Georgescu and his team began investigating how AI could help clinicians fight COVID-19 with faster diagnosis, triaging, and care-pathway planning. The group has leading expertise in developing AI prototype solutions for medical image analysis, and went into battle alongside the clinical experts. Georgescu explains: "Our core competence lies in the provision of AI-based solutions to analyze clinical images – so we put together a team of experts to find out whether and how we can make a contribution with this knowledge." <p><br></p><p>Team member Thomas Re, an experienced radiologist, remembers the situation very well: “As for everyone, it was an extremely intense moment. Having trained in radiology in Milan, Italy, a location particularly hit by COVID-19 infections and fatalities just before the U.S. outbreak, and having heard from friends and colleagues directly affected, I was particularly aware of the gravity of the situation. I saw my work on the AI COVID-19 project as my best opportunity to provide a solution in future that could help in this time of crisis by working to improve COVID-19 diagnostic tools for the clinicians on the font-line of the pandemic. My task, as a radiologist, was to annotate imaging data for use in “training” the AI system to recognize COVID-19 disease patterns in chest CT data. Pulling together resources from around the globe for this project and to be part of such a team was truly amazing. My contribution would not have been possible without the support of other local and international team members; in particular, that of my radiology colleague Eileen Krieg, MD based in New Jersey, engineer Amit Vaze and his India based team as well as engineer Guillaume Chabin and his data management team in Paris.” </p>

<p>Due to the global pandemic, the team was restricted to virtual collaboration in video conferences and used interactive platforms and teamworking tools. "Everyone always had the same level of knowledge," explains Georgescu. His colleague Shikha Chaganti remembers: “We've all been doing it with a smile on our faces. A wonderful sense of community.” This provided the best foundation for meeting the challenge of developing a working prototype at incredible speed, as radiologist Abishek Balachandran confirms: “It was amazing to collaborate on this project. Given that it happened at a time of unprecedented crisis, we’re proud that even in this difficult period our team was able to scale up.” In just three weeks, the first version of the prototype was ready. It would be used to detect and quantify conspicuous tissue structures in the lung on a CT scan.</p>
<p>In order to research the effects of COVID-19 on the lung, the AI team needed reliable comparative values as a solid basis for continuing their work. "When you launch a project like this, you need reliable data and advice from clinical experts right from the start. Only then can we develop the actual prototype. This requires effective algorithms and a powerful computer infrastructure. And finally, it must be possible to make the new concept available to several partners in a clinical setting so that they can test its practical suitability," explains Georgescu.</p><p>Therefore, to build, train, and deploy a machine learning model, the AI scientists and engineers worked hand in hand with dedicated clinical partners. “We have managed to engage and effectively work and collaborate across continents to have an efficient data processing pipeline,” says Georgescu.<br></p>
<p>His team drew on data from COVID-19 cases and additional studies from around 18 collaborating institutes in the U.S., Canada, and Europe – including Foch Hospital (France), Northwell Health (U.S) and Houston Methodist (U.S.), University Hospital Basel (Switzerland), and Vancouver General Hospital (Canada) – as reference values.&nbsp;</p><p><br></p><p>At all these locations, the same measures of lesions, lungs, and lobes were acquired to “feed” the algorithm with relevant data.</p>
Any lung abnormalities for which the SARS-CoV-2 virus could be responsible are automatically identified and classified according to their extent. To do so, a <a href="quantifying algorithm" class="cp-fab-text-highlight">quantifying algorithm</a> systematically analyzes a CT image of the patient’s rib cage and looks for opacity, i.e., hardening in the tissue of the lung lobes. If lesions of this type are detected, the algorithm calculates the density with which they occur in the lung. This type of preselection speeds up the clinical process – and every minute saved provides precious time to initiate proper treatment quickly. Finally, a correlation with the patient's actual symptoms is sought, making it increasingly easy to follow the progress of the disease.
A quantifying algorithm analyzes images and looks for opacity to depict the severity and region of the affected tissue – without assigning the findings to the underlying disease.

<p>The process that was set in motion by Georgescu and his team could become a model for many future developments in terms of its approach, pace, and guiding principles. The pandemic is not all that has spread in the last few months: Pioneering spirit, cross-border project work, and intelligent collaborations have also flourished. An algorithm is just one of the many results to have come to fruition – and it has been shown that, in the fight against COVID-19, hard work and creativity are also contagious. </p>
<p>The prototype was developed to automatically identify and quantify hyperdense lung regions in order to detect the affected area and then assess the severity of the inflamed tissue. This automated quantification of abnormalities associated with COVID-19 from noncontrast chest CT scans could help clinicians to evaluate the disease and to assess its severity and progression. However, the accuracy with which COVID-19 can be distinguished from other types of lung disease on CT images still varies.</p>
COVID-19 can manifest similarly to other respiratory infections such as influenza, which can make patient triaging and diagnosis challenging. It is therefore important to be able to distinguish COVID-19-related pulmonary disease not just from healthy lungs, but also from other types of lung diseases, such as other infections, malignancies, interstitial lung disease, and chronic obstructive pulmonary disease. With that in mind, a number of fundamental questions remain: Can AI automatically detect COVID-19 using chest CT scans? Will an AI system soon be ready to help radiologists distinguish between COVID-19 and other types of pneumonia? And how can we achieve a widespread impact of AI to accelerate the fight against COVID-19? A dedicated AI team is already working on answering these questions… <p><br></p>

By Andrea Lutz
Andrea Lutz is a journalist and business trainer specialized on medical topics, technology, and healthcare IT. She lives in Nuremberg, Germany.