Essential laboratory parameters
Disease severity and risk stratification
Correlation between abnormal coagulation parameters and disease severity
Measuring inflammatory markers
CK and LDH
Cardiac and kidney injury markers
More data needed
List of Abbreviations
Henry BM, Santos de Oliveira MH, Benoit S, et al. Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus disease 2019 (COVID-19): a meta-analysis. Clin Chem Lab Med. Published online April 10, 2020. DOI: 10.1515/cclm-2020-0369;
Xie J, Hungerford D, Chen H, et al. Development and external validation of a prognostic multivariable model on admission for hospitalized patients with COVID-19. medRxiv. Preprint published online April 7, 2020. DOI: 10.1101/2020.03.28.20045997;
Chen N, Zhou M, Dong X, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study, Lancet. 2020;395:507–13. DOI: 10.1016/S0140-6736(20)30211-7;
Green K, Allen AJ, Sukla J, et al. What is the role of imaging and biomarkers within the current testing strategy for the diagnosis of Covid-19? The Centre for Evidence-Based Medicine at the University of Oxford. April 8, 2020. https://www.cebm.net/covid-19/what-is-the-role-of-imaging-and-biomarkers-within-the-current-testing-strategy-for-the-diagnosis-of-covid-19/;
Rodriguez-Morales AJ, Cardona-Ospinaa JA, Gutiérrez-Ocampoa E, et al; Latin American Network of Coronavirus Disease 2019-COVID-19 Research (LANCOVID-19). Clinical, laboratory and imaging features of COVID-19: A systematic review and meta-analysis. Travel Med Infect Dis. Published online March 13, 2020. DOI: 10.1016/j.tmaid.2020.101623;
Lippi G, Plebani M. Laboratory abnormalities in patients with COVID-2019 infection Clin Chem Lab Med. Published online March 3, 2020. DOI: 10.1515/cclm-2020-0198;
Lippi G, Plebani M. The critical role of laboratory medicine during coronavirus disease 2019 (COVID-19) and other viral outbreaks. Clin Chem Lab Med. 2020 Published online March 19, 2020. DOI: 10.1515/cclm-2020-0240;
Ruan Q, Yang K, Wang W, et al. Clinical predictors of mortality due to COVID‑19 based on an analysis of data of 150 patients from Wuhan, China. Intensive Care Med. Published online March 3, 2020. DOI: 10.1007/s00134-020-05991-x;
Yang X, Yu Y, Xu J, et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respir Med.
Published online February 24, 2020.
Tan C, Huang Y, Shi F, et al. C-reactive protein correlates with CT findings and predicts severe COVID-19 early. J Med Virol. Published online April 13, 2020. DOI: 10.1002/jmv.25871;
Henry B, Lippi G, Plebani M. Laboratory abnormalities in children with novel coronavirus disease 2019. Clin Chem Lab Med. Published online March 16, 2020. DOI:10.1515/cclm-2020-0272,
Cao W, Shi L, Chen L, et al. Clinical features and laboratory inspection of novel coronavirus pneumonia (COVID-19) in Xiangyang, Hubei. medRxiv. Preprint published online February 25, 2020. DOI: 10.1101/2020.02.23.20026963;
Lippi G, Plebani M. Procalcitonin in patients with severe coronavirus disease 2019 (COVID-19): A meta-analysis. Clin Chim Acta. 2020;505:190–1. DOI: 10.1016/j.cca.2020.03.004;
Wu C, Chen X, Cai Y, et al. Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China. JAMA Intern Med. Published online March 13, 2020. DOI:10.1001/jamainternmed.2020.0994;
Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. Published online March 9, 2020. DOI: 10.1016/S0140-6736(20)30566-3;
Petrilli CM, Jones SA, Yang J, et al. Factors associated with hospitalization and critical illness among 4,103 patients with Covid-19 disease in New York City. medRxiv. Preprint published online April 11, 2020. DOI: 10.1101/2020.04.08.20057794;
Yao Y, Cao J, Wang Q, et al. D-dimer as a biomarker for disease severity and mortality in COVID-19 patients: a case control study. Research Square. Preprint posted April 3, 2020. DOI: 10.21203/rs.3.rs-20850/v1;
Lippi G, Favaloro E. D-dimer is associated with severity of coronavirus disease 2019: a pooled analysis Thromb Haemost. Published online April 3, 2020.
Tang N, Li D, Wang X, Sun Z. Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J Thromb Haemost. 2020;18:844-7. DOI: 10.1111/jth.14768;
Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395:497–506. https://doi.org/10.1016/S0140-6736(20)30183-5;
Guan WJ, Ni ZY, Hu Y, et al; China Medical Treatment Expert Group for Covid-19. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. Published online February 28, 2020. DOI: 10.1056/NEJMoa2002032;
Thachil J, Tang N, Gando S, et al. ISTH interim guidance on recognition and management of coagulopathy in COVID-19. J Thromb Haemost. Published online March 25, 2020. DOI: 10.1111/JTH.14810;
Wada H, Thachil J, Di Nisio M, et al; The Scientific Standardization Committee on DIC of the International Society on Thrombosis Haemostasis. Guidance for diagnosis and treatment of DIC from harmonization of the recommendations from three guidelines.. J Thromb Haemost. Published online April 11, 2013. DOI: 10.1111/jth.12155;
Qin C, Zhou L, Hu Z, et al. Dysregulation of immune response in patients with COVID-19 in Wuhan, China. Clin Infect Dis. Published online March 12, 2020.
Mehta P, McAuley DF, Brown M, et al. HLH Across Specialty Collaboration, UK. COVID-19: consider cytokine storm syndromes and immunosuppression. Lancet. Published online March 12, 2020. DOI: 10.1016/S0140-6736(20)30630-9
Wang D, Hu B, Hu C, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus–infected pneumonia in Wuhan, China. JAMA. 2020;323:1061–9. DOI:10.1001/jama.2020.1585;
Lippi G, Plebani M, Henry BM. Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A meta-analysis. Clin Chim Acta. 2020;506:145–8. DOI: 10.1016/j.cca.2020.03.022;
Shah V. Meaning of elevated procalcitonin unclear in COVID-19. Massachusetts General Hospital: Advances in Motion. April 20, 2020. https://advances.massgeneral.org/research-and-innovation/article.aspx?id=1174;
Yuan J, Zou R, Zeng L, et al. The correlation between viral clearance and biochemical outcomes of 94 COVID‑19 infected discharged patients. Inflamm Res. Published online March 29, 2020. DOI: 10.1007/s00011-020-01342-0;
Guidon AC, Amato AA. COVID-19 and neuromuscular disorders. Neurology. Published online April 13, 2020. DOI: 10.1212/WNL.0000000000009566;
Madjid M, Safavi-Naeini P, Solomon SD, et al. Potential effects of coronaviruses on the cardiovascular system. A review. JAMA Cardiol. Published online March 27, 2020. doi:10.1001/jamacardio.2020.1286;
Guo T, Fan Y, Chen M, et al. Cardiovascular implications of fatal outcomes of patients with coronavirus disease 2019 (COVID-19). JAMA Cardiol. Published online March 27, 2020. doi:10.1001/jamacardio.2020.1017;
Ronco C, Reis T. Kidney involvement in COVID-19 and rationale for extracorporeal therapies. Nat Rev Nephrol. Published online April 9, 2020. DOI: 10.1038/s41581-020-0284-7;
Wang L, Li X, Chen H, et al, Coronavirus disease 19 infection does not result in acute kidney injury: an analysis of 116 hospitalized patients from Wuhan, China. Am J Nephrol. Published online March 31, 2020. DOI: 10.1159/000507471;
Cheng Y, Luo1 R, Wang K, et al. Kidney disease is associated with in-hospital death of patients with COVID-19. Kidney Int. Kidney Int. Published online March 20, 2020. DOI: 10.1016/j.kint.2020.03.005;
Xiao G, Hu H, Wu F, et al. Acute kidney injury in patients hospitalized with COVID-19 in Wuhan, China: A single-center retrospective observational study. medRxiv. Preprint published online April 6, 2020. DOI: DOI: 10.1101/2020.04.06.20055194;
Li Z, Wu M, Guo J, Yao J, et al; Anti-2019-nCov Volunteers. Caution on kidney dysfunctions of 2019-ncov patients. MedRvix. Published online March 27, 2020. doi: DOI: 10.1101/2020.02.08.20021212.
- All References last accessed April 24, 2020.
- The statements by Siemens Healthineers customers described herein are based on results that were achieved in the customer’s unique setting. Since there is no “typical” hospital and many variables exist (e.g., hospital size, case mix, level of IT adoption) there can be no guarantee that other customers will achieve the same results.