SPECT/CT Quantification for Theranostics

More power than ever to personalize care.
MEDraysintell Nuclear Medicine Report & Directory, Edition 2019.

With more than 1,600 publications referencing theranostics in 20191, there is clear momentum in this fast-growing area of medicine. Combining diagnostics and therapy brings new opportunities for delivering the right treatment at the right time to each patient. But having reliable patient-specific data is essential for achieving this.

When establishing a theranostics practice, differentiating between technologies can be challenging. To better understand why all SPECT/CTs are not created equal, three points quickly rise to the top of the list:

System design is critical for reliably imaging medium- and high-energy isotopes. With sodium iodide crystals, the only SPECT crystal technology clinically proven to manage all SPECT energies, and the flexibility to easily change and use collimators specifically designed for each isotope, Symbia Intevo™ SPECT/CTs provide the technology foundation required for a theranostics program. And with TrueCalc™ high count rate detector technology, there is peace of mind in having consistent quantitative accuracy across the therapy cycle and multiple time points.

Quant Calibration image 1

Conventional quantification calibration workflows can take as many as 14 manual, time-intensive steps—increasing the potential for error. xSPECT Quant™ provides an automated calibration solution that is fast, accurate, and easily implemented into your department’s workflow. With xSPECT Quant, you no longer need to rely on a medical physicist to complete the calibration. Calibration can be easily performed by a technologist, thus allowing for more flexibility within the department.

Precise and reproducible to within 5%2,3, xSPECT Quant provides the degree of standardized SPECT/CT quantification you rely on for theranostics and radionuclide therapy. Using a patented NIST-traceable calibration source, xSPECT Quant is unrivaled in its level of accuracy4, and is your basis for optimal therapy planning and management. xSPECT Quant is available for multiple isotopes, including 177Lu and 131I4.

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What experts say

Ken Herrmann, MD

Ken Herrmann, MD
Chair, Department of Nuclear Medicine
Universitätsklinikum Essen, Germany

“As a guest editor for The Journal of Nuclear Medicine, I had the chance to create a dedicated issue on theranostics. Bringing together and sharing our knowledge will only help propel its use. In my opinion, this is nuclear medicine‘s most exciting development since the introduction of PET and PET/CT.”

The Journal of Nuclear Medicine: Theranostics Supplement (2017)
A collection of 15 articles highlighting the experiences and impressions of researchers and clinicians working in the field.


White paper

Accurate, reproducible and standardized SPECT/CT quantification
Data courtesy of Friedrich Alexander University, Erlangen, Germany.

Written by A. Hans Vija, PhD, Carl von Gall, MD, and Partha Ghosh, MD
Siemens Healthineers Molecular Imaging