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BN ProSpec System

Uncompromising performance for plasma protein analysis

 
 BN ProSpec System

The BN ProSpec® is a dedicated, compact system that offers a consolidated menu of specialty and routine reagents for reliable plasma protein testing including cardiac risk assessment, kidney diseases, nutritional assessment and iron and anemia assessment as well as innovative markers such as monoclonal kappa and lambda free light chains, Cystatin C and Carbohydrate-Deficient Transferrin (CDT).

  • Ideal for low- to mid-volume plasma protein throughput
  • Comprehensive menu from one source: Over 64 assay protocols available for determination of various sample types
  • Optimal alignment of systems and reagents
  • Refrigerated onboard storage of controls and reagents
  • Assistance with clinical interpretation through our innovative range of assessment programs available for Protis® IT Solution.

Features & Benefits

The BN ProSpec® System uses our proven nephelometric technology for the determination of a large variety of assays which support the management of disease states such as iron and anemia assessment, gammopathies / immune system, kidney disease, and many others.  

The BN ProSpec System is a fully automated benchtop analyzer which combines efficient workflow with cost-effective determinations for plasma protein testing needs:

  • Patient-oriented sample processing for efficient workflow
  • Convenient handling due to onboard storage of reagents and controls
  • Highly reliable patient results with optimized system components

The BN ProSpec provides you with:

Increased workflow efficiency

  • Average effective throughput of 65 tests/hour
  • Onboard capacity for up to 1.5 hour walkaway convenience
  • 24-hour onboard refrigerated reagent storage to eliminate removal of controls and reagents
  • Enhanced onboard stability – generally up to 6 weeks for reagents and 1 week for controls
  • Barcode identification for primary sample tubes, standards, controls and reagents
  • Sample auto-dilution and configurable, automatic repeat measurements for fast results with less operator intervention
  • Secure interruption of assay runs for calibration and reloading – no loss of data
  • Specimen level-detection 

Confidence in results

  • Optimal alignment of reagents and system
  • High reliability with antigen-excess security
  • Proven nephelometric technology 

Comprehensive solutions

  • Broad menu available from one source: Over 64 assay protocols available for determination in various body fluids
  • Consolidation of specialty and routine parameters to support disease state management 

Innovative assays:

  • Free Light Chains (FLC) kappa & lambda assays with excellent lot-to-lot reproducibility and high antigen excess security – adding confidence to screening and monitoring of monoclonal gammopathies
  • CardioPhase® hsCRP – a trendsetting assay acknowledged as independent marker of cardiovascular risk
  • Unique, fully automated Carbohydrate-Deficient Transferrin (%CDT) assay with the specificity of HPLC
  • Cystatin C – increasing sensitivity and reliability in renal function analysis
  • Active participation in protein method standardization projects 

Protis®IT Solution1

  • Delivers a comprehensive overview of results for each patient
  • Integrates test results from multiple instruments into one report
  • Simplifies data management
  • Supports a broad range of assessment programs: Iron and Anemia, Nutrition, Cardiac Risk, Kidney and CSF Assessment

Assays

Assay availability varies from country to country

Polyclonal & Monoclonal Gammopathies / Immune System
β2-Microglobulin
FLC kappa
FLC lambda
Ig/light chain, type kappa
Ig/light chain, type lambda
IgA
IgG
IgG subclasses 1-4
IgM

Kidney Disease
Albumin urine
α1-Microglobulin urine
α2-Macroglobulin urine
β2-Microglobulin urine
β-trace protein
Cystatin C (serum)
FLC kappa urine
FLC lambda urine
IgG urine
Ig/light chain, type kappa urine
Ig/light chain, type lambda urine
NGAL
Transferrin urine

Inflammation
α1-Acid glycoprotein
CRP
Fibrinogen
SAA

Autoimmune/Rheumatoid Diseases
ADNase B
ASL
CRP
C3c
C4
RF

Cardiovascular Risk / Acute Cardiac Care
Albumin urine
Apo A-I
Apo B
Cystatin C
Fibrinogen
High Sensitivity CRP (CardioPhase® hsCRP)
Homocysteine
Lp(a)
Myoglobin

Chronic Alcohol Abuse
CDT (Carbohydrate Deficient Transferrin)
Transferrin (for %CDT calculation)

Allergic Diseases
IgE

Nutritional Assessment
Albumin
CRP
Ferritin
Prealbumin
RBP (Retinol Binding Protein)

Coagulation Disorders
AT-III
Fibrinogen
Plasminogen

Anemia/Iron Metabolism
Ferritin
Haptoglobin
Hemopexin
sTfR (Soluble Transferrin Receptor)
Transferrin

Complement Activity
C1 Esterase Inhibitor
C3c
C4

Blood-CSF-Barrier Dysfunction
Albumin
Albumin CSF
β-trace protein (CSF leakage)
FLC kappa CSF
FLC lambda CSF
IgA
IgA CSF
IgG
IgG CSF
IgM
IgM CSF

Other Specialty Analytes
α1-Antitrypsin
α2-Macroglobulin serum
Apo A-II
Apo E
Ceruloplasmin
Fibronectin

Technical Specifications

Measuring principle

Nephelometry; measurement of the scattered light intensity in a fixed angle of 13 - 24 degrees

Methods

More than 60 programmed assay protocols

Sample throughput

Effective: Approx. 65 tests/hour depending on the assay mix
Nominal: 100 tests/hour

Analysis method

Fixed-time kinetics, end-point measurement, VLin Integral

Calibration

Multi-point calibration

Rack transport unit

Segments for 3 control serum vials
Segments for 2 reagent vials
Segments for 15 sample tubes

Dilution unit

1 frame for max. 132 dilution cups

Size of sample tubes

Diameter: 11 - 16 mm
Height: 55 - 100 mm
For pediatric samples:
conical microtubes with a maximum filling volume of 1.5 mL

Barcode types

Automatic reading of different barcode types:
2/5 interleaved
Codabar
Code 39
Code 93
Code 128

Reagent volume

40 µL reagent consumption on average

Sample dilution

1 : 1 to 1 : 32,000

Level detection

For samples, standards, controls, and reagents

Reaction cuvettes

90 disposable cuvettes

Measuring temperature

37 ± 1.5°C

Light source

Infrared high performance LED

Wavelength

840 ± 25 nm

Detector

Photodiode with integrated pre-amplifier

Instrument weight and dimensions

Analyzer dimensions (width x height x depth)
109.2 cm 81.3 cm x 63.5 cm (43 in. x 32 in. x 25 in.)
Computer and monitor dimensions (width x height x depth incl. keyboard)
36.2 cm x 45.7 cm x 54.6 cm (14.25 in. x 18 in. x 21.5 in.)
Printer dimensions (width x height x depth)
40.6 cm x 26.6 cm x 36.8 cm (16 in. x 10.5 in. x 14.5 in.)
Weight
Analyzer: 115,2 kg (254 lbs.)
Computer: 5.9 kg (13 lbs.)
Monitor: 12.6 kg (27.7 lbs.)
Printer: 7.3 kg (16.1 lbs.)

Room environment

Ambient temperature
18 to 32 °C (64 to 89 °F)
Relative humidity
Maintain between 30% and 85% (noncondensing)
Average thermal output
340 BTU/hr (100 W) in standby mode
975 BTU/hr (286 W) in operating mode
Water requirements
Deionized water NCClS Type 2
Microbial count must not exceed 100 CFU/ml

Electrical installation requirements

Voltage
117 to 127 V/50 or 60 Hz
207 to 253 V/50 or 60 Hz
Power consumption
<140 VA (standby mode)
<400 VA (operating mode)

Host interfacing

Download mode, host-query mode, ASTM

Ports

1 Serial (DB-9) (male)
1 10-Base-T/Base TX Ethernet RJ45

Computer and Printer

Terminal
Windows Computer
Printer
Lexmark E260 D or DN or equivalent

1

Product availability varies by country. PROTIS IT Solution is not available for sale in the U.S.

2

Availability varies by country. Not available for sale in the U.S.

3

Connectivity to BN ProSpec System is under development. Not available for sale. Future availability cannot be guaranteed.

4

Not available for sale in the U.S.

5

Dependent on model

6

Sold separately

The products/features (mentioned herein) are not commercially available in all countries. Due to regulatory reasons their future availability cannot be guaranteed. Please contact your local Siemens Healthineers organization for further details.
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