ADVIA 2400 Chemistry System
The right balance of speed and efficiency

ADVIA 2400 Chemistry System
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The ADVIA® 2400 Clinical Chemistry System manages the most demanding workloads and meets high turnaround-time (TAT) goals. Its menu includes methods for testing drugs-of-abuse, therapeutic drugs (TDM) and new assays such as Cystatin C and CardioPhase® hsCRP. The ADVIA 2400 Clinical Chemistry System offers:

ADVIA 2400 Chemistry System

ADVIA 2400 Chemistry System

Features & Benefits

The ADVIA® 2400 Clinical Chemistry System meets today’s high turnaround-time (TAT) goals with a throughput up to 2400 tests/hour. Besides assays for general and specialty chemistries, its menu includes assays for specific protein measurement, drugs-of-abuse testing (DAT) and therapeutic drug monitoring (TDM). Interesting new assays such as Cystatin C, HbA1c with automated sample pretreatment and CardioPhase® hsCRP can now be included into your routine testing. 

The ADVIA 2400 Chemistry System pushes productivity levels while maintaining the reliability and stability that keep laboratories up and running. A rapid 2-second probe cycle time maximizes tube speed and test throughput, and combines with the system’s efficient automation-readiness to provide the turnaround time needed for high-volume laboratories 


Superior Speed and Productivity

  • Throughput of up to 2,400 tests/hour (1,800 photometric and 600 ISE) to manage the heaviest workloads
  • Rapid, consistent 2-second cycle time
  • Throughput of 200 tubes per hour even when running 3 ISE tests and 9 photometric tests per sample
  • Automatic Sample Retain technology, auto-repeat, auto-dilution and auto-reflex testing


Automation Ready

  • Point-in-space aspiration offers connectivity to a track or rack handler without robotics or special hardware
  • Redundant sample loading for built-in backup and easy handling of non-routine samples
  • Direct sampling from track prevents detaining tubes at analyzer and reduces aliquoting


Minimal Intervention Demands

  • Minimal-maintenance ISEs
  • Large onboard reagent capacity and optional concentrated reagents reduce interruptions
  • No-maintenance 37°C incubation oil bath
  • Auto-calibration and auto-QC from refrigerated onboard calibrators and controls
  • Microvolume technology with 32,000 tests onboard and up to 60 days onboard stability improves walkaway time. Usage of concentrated reagents increases maximum capacity
  • Remote diagnostics and ILQC (Inter-Laboratory Quality Control) options


Exceptional Reliability

  • Sample integrity check for icterus, hemolysis and lipemia
  • Sample probe with automatic clot/clog detection, liquid level sensing, short sample detection and crash protection
  • Advances in reagent onboard stability, calibration frequency, interference reduction and assay linearity expansion



Hemoglobin A1c (Enzymatic)

Drugs of Abuse/Toxicology

6-Acetylmorphine (6-AM)*
Barbiturates, Urine
Barbiturates, Serum
Benzodiazepines, Urine
Benzodiazepines, Serum
Cannabinoids (THC)
Cocaine Metabolite
Ethyl Alcohol
Methadone Metabolites
Tricyclic Antidepressants

General Chemistry

Alanine Aminotransferase
Alanine Aminotransferase (P5P)
Albumin (BCG)†,‡
Albumin (BCP)
Alkaline Phosphatase (AMP)§
Alkaline Phosphatase (DEA)**
Aspartate Aminotransferase
Aspartate Aminotransferase (P5P)
Bilirubin, Direct
Bilirubin, Total
Calcium (Arsenazo)
Calcium (CPC)
Carbon Dioxide (Enzymatic)§
Creatine Kinase
Creatinine (Enzymatic)
Gamma-Glutamyltransferase (GGT)
Glucose (Hexokinase)
Glucose (Oxidase)
HDL Cholesterol
Lactate Dehydrogenase (L-P)
Lactate Dehydrogenase (P-L)
LDL Cholesterol
Pancreatic Amylase
Total Iron Binding Capacity (TIBC)
Total Protein
Total Protein, CSF/Urine
Urea Nitrogen (BUN)
Uric Acid

Specific Proteins

α1-Acid Glycoprotein
Antistreptolysin O
Apolipoprotein A1
Apolipoprotein B
β-2 Microglobulin
Complement C3
Complement C4
CRP, High Sensitivity
CRP, Wide Range
Cystatin C
Immunoglobulin A
Immunoglobulin G
Immunoglobulin M
Rheumatoid Factor
Soluble Transferrin Receptor (sTfR)**,††,‡‡

Therapeutic Drug Monitoring (TDM)

Valproic Acid

Validity Testing

Specific Gravity††,§§

Technical Specifications

Type of System Random, continuous access, batch, discrete processing
Throughput Rate Up to 2400 tests/hour: 1800 tests/hour colorimetric, 600 tests/hour ISE
Assays Capacity Onboard 49 including 3 ISE
Sample Handling  
Sample Tubes 5 mL, 7 mL, 10 mL, 2 mL sample cups
Sample Tray 84 samples, positive sample identification
Bar Codes Interleaved 2 of 5, code 39, code 128, Codabar (NW7)
STAT Sample Loading 84, not dedicated
Auto-repeat Automatic repeat testing from the retained pre-diluted sample
Auto-dilution Automatic dilution from retained pre-diluted sample
Auto-reflex Testing Automatic ability to perform 3 additional tests based on results of first test
Primary Probe Liquid Level Sensing, Crash Protection, Clot/Clog Detection, Short Sample Detection
Sample Integrity Check Qualitative check for hemolysis, lipemia and icterus
Microvolume Technology  
Automatic Sample Predilution Samples diluted 1:5 (30 μL sample + 120 μL saline generates up to 15 test results), retained for auto-repeat until results are available
Predilution Tray 120 dilution cuvettes
Original Sample Volume 2 to 30 µL; system uses an average of 2-3 µL per test
Average Reagent Volume 80-120 µL per test
Storage Capacity Onboard 20,000 tests average; Usage of concentrated reagents increases maximum capacity
Reaction Area  
Reaction Tray 340 reusable plastic cuvettes
Cuvette Optical Path Length 6 mm
Reaction Bath Inert fluorocarbon oil circulation system, 37°C
Photometer 14 fixed wavelengths (340, 410, 451, 478, 505, 545, 571, 596, 658, 694, 751, 805, 845, and 884 nm)
Light Source 12V, 50W halogen lamp, cooled by forced water circulation
Assay Methods Endpoint, rate reaction, 2-point rate, multi-point homogeneous immunoassay
Reaction Times 3, 4, 5, 10, 15 and 21 minutes
Automatic Correction Serum blank, cell blank, measurement point change, sample volume change in reassay
Point Forwarding Automatically extends linerarity over assay range samples
Reagent Handling  
Reagent Tray 2 trays, 50 positions each, refrigerated
Reagent Capacity Onboard 46 colorimetric methods
Dispensing System 2 probes with Liquid Level Sensing and Liquid Surface Verification
Reagent Wedges 20, 40 and 70 ml bar-code-labeled wedges
Onboard Stability Up to 60 days
Reagent Inventory Management Tracks tests remaining, lot number, onboard stability and expiration date
Reagent Dilutions Capability to dilute concentrated reagents onboard
Open System Capability  
Channels 200 channels, includes user-defined applications
3rd Party Applications Varies by country, can be configured on system
ISE Indirect simultaneous measurement of Na+, K+, Cl-
Sample Volume 22µL for all three tests
Priming Automatic priming cycle
Electrode Life 30,000 samples or 3 months
Throughput Rate 600 tests/hour; 200 tubes/hour
Calibration Interval Up to 60 days, tracked by software
Auto-Calibration/Auto-QC User-defined time interval or with new reagent wedge
View Calibration/QC Data Graphical display of calibration curve and QC, Siemens Remote Service QC monitoring
Calibration/Control Tray 61 refrigerated positions for calibrators, controls and diluents
Data Management  
Computer Windows® XP, flat panel display
Operator manual and assays sheets on-line
Host Interface RS 232C bidirectional
Data Storage 70,000 patient samples
Maintenance Logs
Schedule and monitor routine maintenance activities via software
Host Query ASCII; system requests work order or batch of work orders from host
General Specifications  
Power Requirements 100/115/200/220/230/240 V +/– 10%, 30 A, 50/60 Hz, 3 KVA
Water Requirements Deionized water
Maximum Water Consumption 40 liters per hour
Drain requirements Minimum of 10.6 gallons (40) liters per hour.
Dimensions ADVIA 2400: 52.8 (h) x 67.4 (w) x 34.1 (d) in, 134 (h) x 171.1 (w) x 86.7 (d) cm
Weight ADVIA 2400: 1,389 lbs. (630 kg)
Compliance cUL, CSA, CE
Noise Specifications Open cover less than 70 db, closed cover less than 45 db
Average Heat Output 5,374 BTU/hour
Operating Temperature Range 18° - 30°C/64° - 86°F
Ambient Humidity 40% - 70%

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Related Products, Services & Resources

* Alliance Application manufactured and distributed by Siemens Healthcare Diagnostics.
Also available in concentrated version.
ADVIA Chemistry XPT System supports concentrated version only.
§ Available only in concentrated version.
** Not available for sale in the U.S.
†† Not currently available on the ADVIA Chemistry XPT System.
‡‡ Alliance Application manufactured by third party, distributed by Siemens Healthcare Diagnostics.
§§ Syva application. Restricted in the U.S. to law enforcement-related use (forensic use only).

Due to local regulations, not all products are available in all countries.