Atellica NEPH 630 System

Smart, Simple, and Secure Protein Testing

The Atellica® NEPH 630 System1 is a mid-volume dedicated nephelometric analyzer that simplifies lab operations in specialty protein testing. The system offers the broadest menu of protein tests for assessment on urine, CSF, plasma, and serum, enabling enhanced quantification of certain health conditions. With innovative assays including FLC, CDT, and BTP, the system supports the assessment and monitoring of cardiovascular risk, kidney diseases, neurological disorders, nutritional status, and other diseases.

  • Expand your testing capabilities with the broadest menu of protein tests on multiple sample types
  • Minimize hands-on time so laboratory staff can focus on high-value responsibilities
  • Streamline your lab workflows with highly intelligent software and IT connectivity
  • Deliver accurate and secure results with antigen excess security
  • Save time and reduce waste with continuous access and smart technology
  • Empower clinicians to improve patient outcomes
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Features & Benefits

Expand your testing capabilities with the broadest menu of protein tests on multiple sample types

  • The industry’s largest nephelometric menu of plasma protein assays with more than 60 assay protocols available
  • Innovative assays including free light chains (FLC), carbohydrate-deficient transferrin (CDT), and beta-trace protein (BTP)
  • Supports a variety of disease states including cardiovascular risk assessment, kidney diseases, neurological disorders, nutritional assessment, iron and anemia assessment, and other diseases


Minimize hands-on time so laboratory staff can focus on high-value responsibilities

  • Flexible use of different sample types in random-access mode allows convenient operation
  • Onboard reagent and control storage provides 24/7 operation, long onboard stability, and minimized operator intervention
  • High sample-loading capacity allows load-and-go processing
  • Positive bar-code ID of primary sample tubes minimizes manual steps and avoids sample mismatch
  • Automatic dilutions and repeat measurement of out-of-range high or low samples are performed without user intervention


Streamline your lab workflows with highly intelligent software and IT connectivity

  • Siemens Remote Service identifies and diagnoses potential hardware issues, enabling rapid technical intervention and quicker resolution
  • Integration with Atellica® PM 1.0 Software2 simplifies lab management via aggregated system data, alerts, and the ability to remotely control Atellica NEPH 630 System2 and all other connected instruments―all from one screen
  • CentraLink® Data Management System standardizes testing protocols and result management


Deliver accurate and secure results

  • Proven nephelometric technology offers high precision and reproducibility
  • Sophisticated antigen-excess pre-reaction protocols provide more accurate results and fewer repeats
  • Wide initial measuring range reduces the need for retesting
  • System detects specimen and reagent levels prior to processing to ensure accuracy of results
  • Graphical display of kinetic curves allows additional insight and advanced troubleshooting
  • State-of-the-art software provides a high level of cyber security


Save time and reduce waste with continuous access and smart technology

  • Flexible dilutions and automatic retesting can often be performed without re-accessing the primary sample
  • Fast average throughput of approximately 65 tests/hour depending on the assay mix. Nominal:100 tests/hour
  • Sophisticated sample dilutions enables you to add tests or retest samples quickly
  • Samples and reagents can be loaded and reloaded continuously without interrupting the assay run


Empower clinicians to improve patient outcomes

  • PROTIS® Assessment Software3 consolidates patient test results into one simple report with algorithm-based interpretation of results to support physicians in clinical decision making
  • Lot-to-lot consistency ensures concordance of results, providing physicians with reliable insight into the progression of disease

 

Assays

Polyclonal and Monoclonal Gammopathies/ Immune System
β2-Microglobulin
FLC kappa4
FLC lambda4
Ig/Light Chain, type kappa
Ig/Light Chain, type lambda
IgA
IgG
IgG subclasses 1-4
IgM

Kidney Disease
α1-Microglobulin urine
α2-Macroglobulin urine4
β2-Microglobulin urine
β-trace protein4
Albumin urine
Cystatin C serum
FLC kappa urine4
FLC lambda urine4
Ig/Light Chain, type kappa urine4
Ig/Light Chain, type lambda urine4
IgG urine
NGAL4
Transferrin urine

Inflammation
α1-Acid Glycoprotein
High-Sensitivity CRP(CardioPhase® hsCRP)
Fibrinogen
SAA4

Autoimmune/Rheumatoid Diseases
ADNase B
ASL
C3c
C4
CRP
RF

Cardiovascular Risk/Acute Cardiac Care
Albumin urine
Apo A-I
Apo B
Cystatin C
Fibrinogen
High- Sensitivity CRP (CardioPhase® hsCRP)
Homocysteine
Lp(a)
Myoglobin

Chronic Alcohol Abuse
CDT
Transferrin (for %CDT calculation)

Allergic Diseases
IgE

Nutritional Assessment
Albumin
CRP
Ferritin
Prealbumin
RBP (retinol-binding protein)

Coagulation Disorders
AT-III
Fibrinogen
Plasminogen

Anemia/Iron Metabolism
Ferritin
Haptoglobin
Hemopexin
sTfR
Transferrin

Complement Activity
C1 Esterase Inhibitor
C3c
C4

Blood-CSF Barrier Dysfunction
Albumin
Albumin CSF
β-trace Protein4
FLC kappa CSF4
FLC lambda CSF4
IgA
IgA CSF
IgG
IgG CSF
IgM
IgM CSF

Other Specialty Analytes
α1-Antitrypsin
α2-Macroglobulin serum
Apo A-II4
Apo E4
Ceruloplasmin
Fibronectin4

Technical Specifications

Measuring principle

Nephelometry; measurement of the scattered light intensity in a fixed angle of 13–24°

Methods

More than 60 programmed assay protocols

Sample throughput

Effective: Approximately 65 tests/hour depending on the assay mix
Nominal: 100 tests/hour

Analysis method

Fixed-time kinetics, end-point measurement, VLin Integral

Calibration

Multi-point calibration

Reagent Rotor

Segments for 3 control serum vials
Segments for 2 reagent vials

Sample Rotor

Segments for 15 sample tubes
Segments for 7 standard vials

Dilution unit

1 frame for max. 96 dilution cups

Size of sample tubes

Diameter: 11–16 mm
Height: 65–100 mm
For pediatric samples:
Conical microtubes with a maximum filling volume of 1.5 mL

Bar code reader

Automatic reading of different bar code types: 2/5 interleaved, Codabar, Code 39, Code 93, Code 128

Reagent volume

40 μL reagent consumption on average

Sample dilution

1:1 to 1:32,000

Level detection

For samples, standards, controls, reagents, and container for system liquid and waste

Reaction cuvettes

90 disposable cuvettes

Measuring temperature

37 ± 1.5°C

Light source

Infrared high performance LED

Wavelength

840 ± 10 nm

Detector

Photodiode with integrated pre-amplifier


Instrument weight and dimensions                                                      

Analyzer dimensions
(W x H x D)

107 x 60 (lids closed) x 63 cm (42.1 x 23.6 x 24.8 in.)

Computer and monitor
dimensions (W x H x D
including keyboard)

Approx. 36 x 46 x 55 cm (14.25 x 18 x 21.5 in.)5

Printer6 dimensions
(W x H x D)

Approx. 41 x 27 x 37 cm (16 x 10.5 x 14.5 in.)5

Analyzer weight

115 kg (254 lb.)

Computer and
monitor weight

Approx. 14 kg (31 lbs)5

Printer weight

Approx. 7 kg (16.1 lb.)5


Room environment

Ambient temperature

18 to 32°C (64 to 89°F)

Relative humidity

<85% (non-condensing)

Average thermal output

404 W in operating mode

Water requirements

Deionized water NCCLS Type 2
Microbial count must not exceed 100 CFU/mL


Electrical installation requirements

Voltage

100 V rating: 90 to 110 V
120 V rating: 108 to 132 V
230 V rating: 207 to 253 V

Power consumption

500 VA (operating mode)

Host interfacing

Download mode, host-query mode, ASTM

Ports

1 10-Base-T/Base TX Ethernet RJ45
1 Serial (DB-9) (male)


Computer and printer

Terminal

Windows computer

Printer6

Standard laser printer

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