ADVIA Chemistry XPT System

An advanced automated clinical chemistry analyzer for high-volume laboratories

The ADVIA® Chemistry XPT System provides timely, reliable results with continuous operation to meet the chemistry workloads of the most demanding laboratories.

  • Delivers high throughput of up to 2400 tests per hour.
  • Manages comprehensive testing with a menu of more than 115 assays.
  • Improves workflow using automation and system technologies such as micro-volume and aliquot retention.
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Features & Benefits

The ADVIA® Chemistry XPT System*** is engineered for continuous operation and timely, accurate results—supporting you to reach your full potential today and be prepared for tomorrow. With an advanced user interface that is easy to use and VeriSmart® Technology to support accuracy of testing, the ADVIA Chemistry XPT System predictably and consistently delivers timely, reliable results to meet expanding workloads. 

Simplified, Continuous Operation
  • Simplify operation and training with the intuitive, icon-driven user interface.
  • Extend walkaway times with concentrated reagents that provide high test capacity onboard.
  • Quickly load most system fluids on the fly.
  • Automate calibration, QC, startup, and shutdown.
Consistent, Predictable Turnaround Time and Accuracy
  • Offer a comprehensive chemistry menu of over 115 assays, including general and specialty chemistry, DAT, TDM, and specific proteins.
  • Push productivity with a throughput of up to 2400 tests per hour (1800 photometric, plus 600 ISE).
  • Control testing: STAT and specialty samples can always be front-loaded while an automation track is running.
Prof. Giorgia BellomoMedical Director, Central LaboratoryHospital Ospedale Maggiore della Carità di Novara
Designed for Automation
Dr. Hannes WickertSpecialist DoctorLabor Blackholm MVZ, Heilbronn, Germany
Learn how micro-volume and aliquot retention innovations achieve more results with less sample, reagent, waste, and equipment.
  • Reduce blood-draw requirements with micro-volume technology that uses a single 30 μL sample for up to 15 tests.
  • Eliminate sample callback with automated, pre-programmable dilution, reflex, and rerun testing that uses an onboard aliquot.
  • Improve workflow and accuracy with VeriSmart® technologies that perform hardware and software checks at all stages of sample processing.

Assays

Diabetes

Fructosamine
Hemoglobin A1c (Enzymatic)

Drugs of Abuse/Toxicology

6-Acetylmorphine (6-AM)*
Acetaminophen
Amphetamines
Barbiturates, Urine
Barbiturates, Serum
Benzodiazepines, Urine
Benzodiazepines, Serum
Buprenorphine*
Cannabinoids (THC)
Cocaine Metabolite
Ecstasy
Ethyl Alcohol
Methadone
Methadone Metabolites
Opiates
Oxycodone*
Phencyclidine
Propoxyphene
Salicylate
Tricyclic Antidepressants

General Chemistry

Alanine Aminotransferase
Alanine Aminotransferase (P5P)
Albumin (BCG)†,‡
Albumin (BCP)
Alkaline Phosphatase (AMP)§
Alkaline Phosphatase (DEA)**
Ammonia
Amylase
Aspartate Aminotransferase
Aspartate Aminotransferase (P5P)
Bilirubin, Direct
Bilirubin, Total
Calcium (Arsenazo)
Calcium (CPC)
Carbon Dioxide (Enzymatic)§
Chloride
Cholesterol
Cholinesterase
Creatine Kinase
Creatinine
Creatinine (Enzymatic)
Gamma-Glutamyltransferase (GGT)
Glucose (Hexokinase)
Glucose (Oxidase)
HDL Cholesterol
Iron
Lactate
Lactate Dehydrogenase (L-P)
Lactate Dehydrogenase (P-L)
LDL Cholesterol
Lipase
Magnesium
Microalbumin
Pancreatic Amylase
Phosphorus
Potassium
Sodium
Total Iron Binding Capacity (TIBC)
Total Protein
Total Protein, CSF/Urine
Triglycerides
Urea Nitrogen (BUN)
Uric Acid

Specific Proteins

α1-Acid Glycoprotein
α1-Antitrypsin
Antistreptolysin O
Apolipoprotein A1
Apolipoprotein B
β-2 Microglobulin
Complement C3
Complement C4
CRP
CRP, High Sensitivity
CRP, Wide Range
Cystatin C
Ferritin
Haptoglobin
Immunoglobulin A
Immunoglobulin G
Immunoglobulin M
Lipoprotein(a)
Myoglobin
Prealbumin
Rheumatoid Factor
Soluble Transferrin Receptor (sTfR)**,††,‡‡
Transferrin

Therapeutic Drug Monitoring

Carbamazepine
Digoxin
Gentamicin
Lithium
Methotrexate††,‡‡
Phenobarbital
Phenytoin
Theophylline
Tobramycin
Valproic Acid
Vancomycin

Validity Testing

Creatinine††,§§
Nitrite††,§§
Oxidant††,§§
pH††,§§
Specific Gravity††,§§

Technical Specifications

Product Specifications 

System Description

Fully random and continuous access, discrete processing clinical chemistry system with batch run capability

Test Throughput

Up to 2400 tests/hour: 1800 tests/hour photometric, 600 tests/hour ISE

Assays Onboard

59 assays, including 3 ISE (Na, K, Cl)

Sample Handling

Sample Tubes

5 mL, 7 mL, and 10 mL tubes; 1 mL and 2 mL sample cups; user-defined containers

Sample Tray

84 sample positions; positive sample identification

Validated Sample Types

Serum, plasma, urine, whole blood, and CSF, assay-dependent

Sample Integrity Control

Qualitative check for hemolysis, lipemia, and icterus; clot detection, flagging, and management; short-sample detection, flagging, and management

STAT Handling

84 positions, not dedicated; STAT samples are processed with priority

Auto-repeat Testing

Automatic repeat testing from the retained prediluted sample or original sample

Sample Dilution

Automatic dilution up to 1:5625 from retained prediluted sample or original sample

Auto-reflex Testing

Automatic ability to perform additional tests based on results of first test or test combination

Primary Sample Probe

Liquid-level sensing, crash protection, clot/clog detection, liquid-surface verification

Sample Carryover Prevention

Automated wash; additional automated sample probe washes programmable for greater prevention

Sample Throughput

Up to 200 tubes per hour with ISE use; faster without ISE use

Bar Codes  

Sample Bar Codes

Up to 20 digits; Interleaved 2 of 5, Code 39, Code 128, Codabar; A, B, and special characters (.-+/*$%)

Micro-volume Technology  

Automatic Sample Predilution

Samples typically diluted 1:5 (30 μL sample + 120 μL saline generates up to 15 tests results); retained for auto-repeat, auto-reflex, or auto-dilution until results are available

Predilution Tray

120 dilution cuvettes

Sample Volume per Test

2–30 μL of prediluted sample, equating to 0.4–6.0 μL of original sample per test (varies by assay)

Average Reagent Volume

80–120 μL per test, assay-dependent

Reaction Area  

Reaction Cuvettes

340 reusable optical-grade plastic cuvettes

Reaction Bath

Inert fluorocarbon oil circulation system, 37°C

Photometer

14 fixed wavelengths (340, 410, 451, 478, 505, 545, 571, 596, 658, 694, 751, 805, 845, and 884 nm)

Light Source

12V, 50W halogen lamp, cooled by forced water circulation

Assay Result Calculations

Endpoint (EPA), rate reaction (RRA), 2-point rate (2PA), constant rate analysis (CRA), and immunoassay analysis (IMA) methodologies; prozone checking; substrate depletion check; results available as completed

Reaction Times

3, 4, 5, and 10 minutes; extended reaction times 15 and 21 minutes

Automatic Correction

Sample blank, cuvette blank, measurement point change, sample volume change in re-assay

Point Forwarding

Can automatically extend linearity to measure samples over assay range

Assay Technology

Potentiometric, photometric, turbidimetric

Reagent Handling

Reagent Tray

2 trays, (R1=60 and R2 =56 positions), refrigerated between 6°C and 13°C (43°F–55°F)

Reagent Capacity Onboard

56 photometric assays

Test Capacity Onboard

40,000 photometric tests average; over 100,000 photometric tests with the use of concentrated reagents

Reagent Containers

20, 40, 70 mL reagent wedges

Reagent Integrity Control

Bar-code reagent identification; automatic inventory tracking and flagging; calibration and control validity tracking and flagging; reagent onboard stability tracking and flagging; reagent expired/reagent low flagging

Onboard Stability

Up to 60 days, depending on assay

Reagent Dilutions

Capability to dilute concentrated reagents onboard

Open-system Capability  

Channels

200 assay channels; includes 50 channels for user-defined applications

Ion-selective Electrodes (ISE)

ISE

Indirect simultaneous measurement of Na+, K+, Cl-

ISE Sample Volume

22 μL original sample for all three tests

Electrode Expected Use Life

30,000 samples or 3 months, whichever occurs first

Throughput Rate

Up to 600 tests/hour; 200 tubes/hour

Calibration/QC  

Validated Calibration Interval

Up to 60 days, tracked by software

Auto-calibration

User-defined time interval or with new reagent container

Auto-QC

User-defined test count interval or with auto-calibration

View Calibration

Graphical display of calibration curves

QC Data

Graphical display of QC; real-time/QC monitoring; Advanced QC package includes Levey-Jennings plots, Westgard rules, and RiliBÄK rules; 125,000 control results can be stored, archivable to removable media

Calibration/Control Tray

61 refrigerated positions for calibrators, controls, and diluents

User Interface/Data Management  

Monitor

22-inch (55.9 cm) diagonal high-resolution LCD touchscreen with adjustable height

Operating System

Microsoft® Windows® 7

System Documentation

Operator manual, quickstart guide, and online help

Data Storage

500,000 active plus 500,000 historical test results; can archive to removable media

Onboard Maintenance Logs

Yes

Host Interface

TCP/IP bidirectional

Host Query

ASTM; system requests work order or batch of work orders from host

Remote Access and Service

Siemens Remote Service via 1000BASE-T Ethernet port

Removable Media  

Removable Media

DVD, CD-RW, or USB

General Specifications

Power Requirements

200–240V at 50/60 Hz, 3 kVA consumption

Water Requirements

CLSI® Clinical Laboratory Reagent Water or equivalent connected directly to a pressurized water source

Maximum Water Consumption

40 liters (10.6 gallons) per hour

Drain Requirements

Minimum of 40 liters (10.6 gallons) per hour

Dimensions

With monitor: 149 (h) x 177 (w) x 99 (d) cm; 59 (h) x 70 (w) x 39 (d) inches
Without monitor: 134 (h) x 177 (w) x 99 (d) cm; 53 (h) x 70 (w) x 39 (d) inches

Weight

725 kg (1598 lb)

Compliance

Complies with international environmental, health, and safety standards, including CE and RoHS

Noise Emission

Less than 62 dB

Processing Heat Output

5374 BTU/hour

Ambient Temperature

18°–30°C (64°-86°F)

Ambient Humidity

20–80% noncondensing