ADVIA 2400 Chemistry System

The right balance of speed and efficiency

The ADVIA® 2400 Clinical Chemistry System manages the most demanding workloads and meets high turnaround-time (TAT) goals. Its menu includes methods for testing drugs-of-abuse, therapeutic drugs (TDM) and new assays such as Cystatin C and CardioPhase® hsCRP. The ADVIA 2400 Clinical Chemistry System offers:

  • High throughput of up to 2,400 tests/hour (1,800 photometric and 600 ISE) to manage  heavy workloads
  • Rapid, consistent 2-second cycle time for faster tube speed and test throughput
  • User-defined automatic repeat, dilution, and reflex testing
  • Large onboard reagent capacity and optional concentrated reagents help to minimize intervention demands
  • Refrigerated onboard storage of controls and reagents for extended stability and increased productivity
  • Automation ready design – no additional hardware required
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Features & Benefits

The ADVIA® 2400 Clinical Chemistry System meets today’s high turnaround-time (TAT) goals with a throughput up to 2400 tests/hour. Besides assays for general and specialty chemistries, its menu includes assays for specific protein measurement, drugs-of-abuse testing (DAT) and therapeutic drug monitoring (TDM). Interesting new assays such as Cystatin C, HbA1c with automated sample pretreatment and CardioPhase® hsCRP can now be included into your routine testing.

The ADVIA 2400 Chemistry System pushes productivity levels while maintaining the reliability and stability that keep laboratories up and running. A rapid 2-second probe cycle time maximizes tube speed and test throughput, and combines with the system’s efficient automation-readiness to provide the turnaround time needed for high-volume laboratories 

Superior Speed and Productivity

  • Throughput of up to 2,400 tests/hour (1,800 photometric and 600 ISE) to manage the heaviest workloads
  • Rapid, consistent 2-second cycle time
  • Throughput of 200 tubes per hour even when running 3 ISE tests and 9 photometric tests per sample
  • Automatic Sample Retain technology, auto-repeat, auto-dilution and auto-reflex testing

Automation Ready

  • Point-in-space aspiration offers connectivity to a track or rack handler without robotics or special hardware
  • Redundant sample loading for built-in backup and easy handling of non-routine samples
  • Direct sampling from track prevents detaining tubes at analyzer and reduces aliquoting

Minimal Intervention Demands

  • Minimal-maintenance ISEs
  • Large onboard reagent capacity and optional concentrated reagents reduce interruptions
  • No-maintenance 37°C incubation oil bath
  • Auto-calibration and auto-QC from refrigerated onboard calibrators and controls
  • Microvolume technology with 32,000 tests onboard and up to 60 days onboard stability improves walkaway time. Usage of concentrated reagents increases maximum capacity
  • Remote diagnostics and ILQC (Inter-Laboratory Quality Control) options

Exceptional Reliability

  • Sample integrity check for icterus, hemolysis and lipemia
  • Sample probe with automatic clot/clog detection, liquid level sensing, short sample detection and crash protection
  • Advances in reagent onboard stability, calibration frequency, interference reduction and assay linearity expansion

Assays

Diabetes

Fructosamine
Hemoglobin A1c (Enzymatic)

Drugs of Abuse/Toxicology

6-Acetylmorphine (6-AM)*
Acetaminophen
Amphetamines
Barbiturates, Urine
Barbiturates, Serum
Benzodiazepines, Urine
Benzodiazepines, Serum
Buprenorphine*
Cannabinoids (THC)
Cocaine Metabolite
Ecstasy
Ethyl Alcohol
Methadone
Methadone Metabolites
Opiates
Oxycodone*
Phencyclidine
Propoxyphene
Salicylate
Tricyclic Antidepressants

General Chemistry

Alanine Aminotransferase
Alanine Aminotransferase (P5P)
Albumin (BCG)†,‡
Albumin (BCP)
Alkaline Phosphatase (AMP)§
Alkaline Phosphatase (DEA)**
Ammonia
Amylase
Aspartate Aminotransferase
Aspartate Aminotransferase (P5P)
Bilirubin, Direct
Bilirubin, Total
Calcium (Arsenazo)
Calcium (CPC)
Carbon Dioxide (Enzymatic)§
Chloride
Cholesterol
Cholinesterase
Creatine Kinase
Creatinine
Creatinine (Enzymatic)
Gamma-Glutamyltransferase (GGT)
Glucose (Hexokinase)
Glucose (Oxidase)
HDL Cholesterol
Iron
Lactate
Lactate Dehydrogenase (L-P)
Lactate Dehydrogenase (P-L)
LDL Cholesterol
Lipase
Magnesium
Microalbumin
Pancreatic Amylase
Phosphorus
Potassium
Sodium
Total Iron Binding Capacity (TIBC)
Total Protein
Total Protein, CSF/Urine
Triglycerides
Urea Nitrogen (BUN)
Uric Acid

Specific Proteins

α1-Acid Glycoprotein
α1-Antitrypsin
Antistreptolysin O
Apolipoprotein A1
Apolipoprotein B
β-2 Microglobulin
Complement C3
Complement C4
CRP
CRP, High Sensitivity
CRP, Wide Range
Cystatin C
Ferritin
Haptoglobin
Immunoglobulin A
Immunoglobulin G
Immunoglobulin M
Lipoprotein(a)
Myoglobin
Prealbumin
Rheumatoid Factor
Soluble Transferrin Receptor (sTfR)**,††,‡‡
Transferrin

Therapeutic Drug Monitoring

Carbamazepine
Digoxin
Gentamicin
Lithium
Methotrexate††,‡‡
Phenobarbital
Phenytoin
Theophylline
Tobramycin
Valproic Acid
Vancomycin

Validity Testing

Creatinine††,§§
Nitrite††,§§
Oxidant††,§§
pH††,§§
Specific Gravity††,§§

Technical Specifications

Overview

Type of System

Random, continuous access, batch, discrete processing

Throughput Rate

Up to 2400 tests/hour: 1800 tests/hour colorimetric, 600 tests/hour ISE

Assays Capacity Onboard

49 including 3 ISE

Sample Handling

Sample Tubes

5 mL, 7 mL, 10 mL, 2 mL sample cups

Sample Tray

84 samples, positive sample identification

Bar Codes

Interleaved 2 of 5, code 39, code 128, Codabar (NW7)

STAT Sample Loading

84, not dedicated

Auto-repeat

Automatic repeat testing from the retained pre-diluted sample

Auto-dilution

Automatic dilution from retained pre-diluted sample

Auto-reflex Testing

Automatic ability to perform 3 additional tests based on results of first test

Primary Probe

Liquid Level Sensing, Crash Protection, Clot/Clog Detection, Short Sample Detection

Sample Integrity Check

Qualitative check for hemolysis, lipemia and icterus

Microvolume Technology

Automatic Sample Predilution

Samples diluted 1:5 (30 μL sample + 120 μL saline generates up to 15 test results), retained for auto-repeat until results are available

Predilution Tray

120 dilution cuvettes

Original Sample Volume

2 to 30 µL; system uses an average of 2-3 µL per test

Average Reagent Volume

80-120 µL per test

Storage Capacity Onboard

20,000 tests average; Usage of concentrated reagents increases maximum capacity

Reaction Area

Reaction Tray

340 reusable plastic cuvettes

Cuvette Optical Path Length

6 mm

Reaction Bath

Inert fluorocarbon oil circulation system, 37°C

Photometer

14 fixed wavelengths (340, 410, 451, 478, 505, 545, 571, 596, 658, 694, 751, 805, 845, and 884 nm)

Light Source

12V, 50W halogen lamp, cooled by forced water circulation

Assay Methods

Endpoint, rate reaction, 2-point rate, multi-point homogeneous immunoassay

Reaction Times

3, 4, 5, 10, 15 and 21 minutes

Automatic Correction

Serum blank, cell blank, measurement point change, sample volume change in reassay

Point Forwarding

Automatically extends linerarity over assay range samples

Reagent Handling

Reagent Tray

2 trays, 50 positions each, refrigerated

Reagent Capacity Onboard

46 colorimetric methods

Dispensing System

2 probes with Liquid Level Sensing and Liquid Surface Verification

Reagent Wedges

20, 40 and 70 ml bar-code-labeled wedges

Onboard Stability

Up to 60 days

Reagent Inventory Management

Tracks tests remaining, lot number, onboard stability and expiration date

Reagent Dilutions

Capability to dilute concentrated reagents onboard

Open System Capability

Channels

200 channels, includes user-defined applications

3rd Party Applications

Varies by country, can be configured on system

ISE

ISE

Indirect simultaneous measurement of Na+, K+, Cl-

Sample Volume

22µL for all three tests

Priming

Automatic priming cycle

Electrode Life

30,000 samples or 3 months

Throughput Rate

600 tests/hour; 200 tubes/hour

Calibration/QC

Calibration Interval

Up to 60 days, tracked by software

Auto-Calibration/Auto-QC

User-defined time interval or with new reagent wedge

View Calibration/QC Data

Graphical display of calibration curve and QC, Siemens Remote Service QC monitoring

Calibration/Control Tray

61 refrigerated positions for calibrators, controls and diluents

Data Management

Computer

Windows® XP, flat panel display

System
Documentation

Operator manual and assays sheets on-line

Host Interface

RS 232C bidirectional

Data Storage

70,000 patient samples

Onboard
Maintenance Logs

Schedule and monitor routine maintenance activities via software

Host Query

ASCII; system requests work order or batch of work orders from host

General Specifications

Power Requirements

100/115/200/220/230/240 V +/– 10%, 30 A, 50/60 Hz, 3 KVA

Water Requirements

Deionized water

Maximum Water Consumption

40 liters per hour

Drain requirements

Minimum of 10.6 gallons (40) liters per hour.

Dimensions

ADVIA 2400: 52.8 (h) x 67.4 (w) x 34.1 (d) in, 134 (h) x 171.1 (w) x 86.7 (d) cm

Weight

ADVIA 2400: 1,389 lbs. (630 kg)

Compliance

cUL, CSA, CE

Noise Specifications

Open cover less than 70 db, closed cover less than 45 db

Average Heat Output

5,374 BTU/hour

Operating Temperature Range

18° - 30°C/64° - 86°F

Ambient Humidity

40% - 70%