ADVIA 1800 Chemistry System

Pushing the limit of productivity

The ADVIA® 1800 Clinical Chemistry System pushes the limit of productivity. Its extensive menu allows integration of testing for clinical chemistry, drugs-of-abuse, therapeutic drug monitoring (TDM) and specific proteins like Cystatin C and CardioPhase® hsCRP. The ADVIA 1800 Clinical Chemistry System offers:

  • Throughput of up to 1,800 tests per hour provides speed to keep pace with workload peaks
  • 200 basic metabolic panels per hour to meet turnaround-time demands
  • Large onboard reagent capacity and optional concentrated reagents to reduce interruptions
  • Optimal standardization of reagents and systems for efficient consumable usage
  • Refrigerated onboard storage of controls and reagents for extended stability and increased productivity
  • Automation ready design – no additional hardware required
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Features & Benefits

The ADVIA 1800® Clinical Chemistry System pushes the limit of productivity of the core lab and meets the turnaround-time (TAT) goals of today’s laboratories. Its extensive and growing menu allows integration of general clinical chemistry testing with testing for drugs-of-abuse, therapeutic drug monitoring (TDM), special chemistry and specific proteins like Cystatin C and CardioPhase® hsCRP.

  

The ADVIA 1800 Clinical Chemistry System is an ideal solution for mid- to high-volume chemistry analysis. Featuring intuitive new software and capabilities, it’s designed to deliver power and speed to meet the most demanding performance needs. The ADVIA 1800 System moves laboratories to smarter chemistry testing.

Automation ready design

  • Point-in-space aspiration offers connectivity to a track, VersaCell or rack handler without robotics or special hardware
  • Redundant sample loading for built-in backup and easy handling of non-routine samples
  • Direct sampling from track prevents detaining tubes at analyzer and reduces aliquoting

Peak productivity

  • Throughput of up to 1,800 tests per hour provides the speed to keep pace with workload peaks
  • 200 Basic metabolic panels per hour to meet turnaround-time demands
  • Automatic Sample Retain technology provides the ability to perform reruns and dilutions without the need to retrieve primary tubes
  • Consolidation power with a comprehensive menu, consistent cycle times, speed and open application capability

Total system reliability

  • Minimal-maintenance ISEs
  • Robust hardware and simplified software design, with automatic calibration validation and tracking
  • Advances in reagent onboard stability, calibration frequency, interference reduction and assay linearity expansion
  • Direct water connection
  • Remote diagnostics and ILQC (Inter-Laboratory Quality Control) options

Easy efficiency

  • Large onboard reagent capacity and optional concentrated reagents reduce interruptions
  • High-resolution touchscreen delivers push-button operation
  • Reagent pause capability and onboard Sample Pause button make loading easy
  • Minimal maintenance requirements, including no-maintenance oil bath
  • Sample integrity checking, including serum indices reporting, short sample flagging and clot detection, reduces manual intervention

Assays

Diabetes

Fructosamine
Hemoglobin A1c (Enzymatic)

Drugs of Abuse/Toxicology

6-Acetylmorphine (6-AM)*
Acetaminophen
Amphetamines
Barbiturates, Urine
Barbiturates, Serum
Benzodiazepines, Urine
Benzodiazepines, Serum
Buprenorphine*
Cannabinoids (THC)
Cocaine Metabolite
Ecstasy
Ethyl Alcohol
Methadone
Methadone Metabolites
Opiates
Oxycodone*
Phencyclidine
Propoxyphene
Salicylate
Tricyclic Antidepressants

General Chemistry

Alanine Aminotransferase
Alanine Aminotransferase (P5P)
Albumin (BCG)†,‡
Albumin (BCP)
Alkaline Phosphatase (AMP)§
Alkaline Phosphatase (DEA)**
Ammonia
Amylase
Aspartate Aminotransferase
Aspartate Aminotransferase (P5P)
Bilirubin, Direct
Bilirubin, Total
Calcium (Arsenazo)
Calcium (CPC)
Carbon Dioxide (Enzymatic)§
Chloride
Cholesterol
Cholinesterase
Creatine Kinase
Creatinine
Creatinine (Enzymatic)
Gamma-Glutamyltransferase (GGT)
Glucose (Hexokinase)
Glucose (Oxidase)
HDL Cholesterol
Iron
Lactate
Lactate Dehydrogenase (L-P)
Lactate Dehydrogenase (P-L)
LDL Cholesterol
Lipase
Magnesium
Microalbumin
Pancreatic Amylase
Phosphorus
Potassium
Sodium
Total Iron Binding Capacity (TIBC)
Total Protein
Total Protein, CSF/Urine
Triglycerides
Urea Nitrogen (BUN)
Uric Acid

Specific Proteins

α1-Acid Glycoprotein
α1-Antitrypsin
Antistreptolysin O
Apolipoprotein A1
Apolipoprotein B
β-2 Microglobulin
Complement C3
Complement C4
CRP
CRP, High Sensitivity
CRP, Wide Range
Cystatin C
Ferritin
Haptoglobin
Immunoglobulin A
Immunoglobulin G
Immunoglobulin M
Lipoprotein(a)
Myoglobin
Prealbumin
Rheumatoid Factor
Soluble Transferrin Receptor (sTfR)**,††,‡‡
Transferrin

Therapeutic Drug Monitoring

Carbamazepine
Digoxin
Gentamicin
Lithium
Methotrexate††,‡‡
Phenobarbital
Phenytoin
Theophylline
Tobramycin
Valproic Acid
Vancomycin

Validity Testing

Creatinine††,§§
Nitrite††,§§
Oxidant††,§§
pH††,§§
Specific Gravity††,§§

Technical Specifications

Overview

Type of System

Random, continuous access, batch, discrete processing

Throughput Rate

Up to 1800 tests/hour: 1200 tests/hour colorimetric, 600 tests/hour ISE

Assay Capacity Onboard

55 including 3 ISE

Sample Handling

Sample Tubes

5 mL, 7 mL, 10 mL tubes, 2 mL sample cups

Sample Tray

84 samples, positive sample identification

Sample Integrity Check

Qualitative check for hemolysis, lipemia, and icterus

STAT Sample Loading

84, not dedicated

Bar Codes

Interleaved 2 of 5, Code 39, Code 128, Codabar (NW7)

Auto-repeat

Automatic repeat testing from the retained prediluted sample or original sample

Auto-dilution

Automatic dilution from retained prediluted sample

Auto-reflex Testing

Automatic ability to perform 3 additional tests based on results of first test

Primary Probe

Liquid Level Sensing, Crash Protection, Clot/Clog Detection, Short Sample Detection

Microvolume Technology

Automatic Sample Predilution

Samples diluted 1:5 (30 μL sample + 120 μL saline generates up to 15 tests), retained for auto-repeat until results are available

Predilution Tray

120 dilution cuvettes

Original Sample Volume

2 to 30 μL; average of 2-3 μL per test

Average Reagent Volume

80-120 μL per test

Storage Capacity Onboard

25,200 tests average; Usage of concentrated reagents increases maximum capacity

Reaction Area

Reaction Tray

221 reusable plastic cuvettes

Cuvette Optical Path Length

10 mm

Reaction Bath

Inert fluorocarbon oil circulation system, 37°C

Photometer

14 fixed wavelengths (340, 410, 451, 478, 505, 545, 571, 596, 658, 694, 751, 805, 845, and 884 nm)

Light Source

12 V, 50 W halogen lamp, cooled by forced water circulation

Assay Methods

Endpoint, rate reaction, 2-point rate, multipoint homogeneous immunoassay

Reaction Times

3, 4, 5, 10, 15, and 21 minutes

Automatic Correction

Serum blank, cell blank, measurement point change, sample volume change in reassay

Point Forwarding

Automatically extends linearity over assay range samples

Reagent Handling

Reagent Tray

2 trays, 56 positions each, refrigerated

Reagent Capacity Onboard

52 colorimetric methods

Dispensing System

2 probes with Liquid Level Sensing and Liquid Surface Verification

Reagent Wedges

20, 40, 70 mL bar-code-labeled wedges

Reagent Inventory Management

Tracks tests remaining, lot number, onboard stability, and expiration date

Reagent Dilutions

Capability to dilute concentrated reagents onboard

Onboard Stability

Up to 60 days

Open System Capability

Channels

200 channels, includes user-defined applications

3rd Party Applications

Varies by country, can be configured on system

ISE

ISE

Indirect simultaneous measurement of Na+, K+, Cl -

Sample Volume

22 μL for all three tests

Priming

Automatic priming cycle

Electrode Shelf Life

30,000 samples or 3 months

Throughput Rate

600 tests/hour; 200 tubes/hour

Calibration/QC

Calibration Interval

Up to 60 days, tracked by software

Auto-calibration/Auto-QC

User-defined time interval or with new reagent container

View Calibration/QC Data

Graphical display of calibration curves and QC; Siemens Remote Service QC monitoring

Calibration/Control Tray

61 refrigerated positions for calibrators, controls, and diluents

Data Management

Operating Computer

Windows® XP, 1 GB RAM, touch screen monitor 19”

System Documentation

Operator manual and assay sheets online

Host Interface

RS 232C bidirectional

Data Storage

70,000 patient tests

Onboard Maintenance Logs

Schedule and monitor routine maintenance activities via software

Host Query

ASCII; system requests work order or batch of work orders from host

General Specifications

Power Requirements

200/220/230/240 V +/– 10%, 20 A, 50/60 Hz, 3 KVA

Water Requirements

Deionized water from pressurized water (10-30 psi/169-207 KPa) Average Consumption: 30 liters per hour

Drain Requirements

Minimum of 40 liters per hour

Dimensions

ADVIA 1800: 44.6 (h) x 58.3 (w) x 34.5 (d) in, 113.3 (h) x 148.0 (w) x 87.6 (d) cm

Weight

ADVIA 1800: 1,323 lbs (600 kg)

Compliance

UL, cUL, CE

Noise Specifications

Open cover less than 70 db

Average Heat Output

4,299 BTU/hour @ 50 Hz, 3,023 BTU/hour @ 60 Hz

Operating Temperature Range

18°-30°C/64°-86°F

Ambient Humidity

40%-70%