The only Free Light Chain assay with FDA clearance for evaluation of MGUS
The Siemens Healthineers N Latex FLC Assay is FDA cleared for the Evaluation of patients with MGUS*
Free light chains, kappa (κ) lambda (λ), are produced by plasma cells and known to be an important marker in patients with Multiple Myeloma and AL Amyloidosis. The precursor condition to Multiple Myeloma is called Monoclonal Gammopathy of Undetermined Significance (MGUS) and although these individuals are not immediately treated, they are closely monitored due to their risk of progression to Multiple Myeloma.8
Webinar: Evaluating MGUS with Free Light Chain Assays in Clinical Practice
We invite you to view our webinar with Dr. John Mitsios, PhD, as he discusses the potential clinical usage of the N-Latex FLC assay in evaluation of MGUS.
Learning Objectives:
- Define multiple myeloma and monoclonal gammopathy of undetermined significance (MGUS)
- Describe the clinical criteria used to define multiple myeloma
- Describe the use of free light chains in the evaluation of MGUS
The N-Latex FLC Assay Difference
The N Latex FLC assay for Free Light Chains uses multiple monoclonal antibodies for detection and is reported to have no false positive κ/λ ratios in patients with renal impairment5-7. Since renal impairment may confound MGUS diagnosis, the low false positive rate of the N Latex FLC assay compared to other assays 5-7 provides confidence that abnormal FLC ratio is truly due to a monoclonal disorder.
The N-Latex FLC Difference
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*in addition to diagnosis and monitoring of patients with Multiple Myeloma and diagnosis of patients with AL Amyloidosis
Kyle et. al. NEJM 2006
Seer.cancer.gov 2021
Rajkumar et. al. Blood 2005
Gran et. al. Am J. Hematol. 2021
Jacobs et. al. Clin Chem Lab Med 2014
Rindlisbacher et. al. J Applied Lab Med 2020
Sprangers et. al. Kidney International Reports 2020
Kyle et. Al. Leukemia 2010
