Enhance patient care with a simple blood test for specific allergens
Making allergy testing routineEnhance patient care with a simple blood test for specific allergens
Allergies are common and affect people of all ages, genders, and ethnicities. Reported allergies are more prevalent than ever and are sending increasing numbers of people to hospitals on a global scale. The WHO estimates that 20% of the global population suffers from IgE-mediated allergic diseases, placing heavy financial strains on clinician and hospital resources, particularly in emergent situations.¹
Allergic reactions can range from mild to severe and manifest themselves as allergic asthma, allergic rhinitis, allergic conjunctivitis, atopic eczema/atopic dermatitis, or anaphylaxis. These manifestations may vary between adults and children. Hospitalization for allergy-related anaphylaxis is on the rise in the U.S., Australia, Europe, and other regions.²
The guideline supported by both European- and U.S.-based allergy organizations for allergy diagnosis includes a medical history, physical exam, and testing by either an in vitro method (such as 3gAllergy™) or an in vivo method (skin prick testing) to aid in diagnosis.³
Allergies are diagnosed by beginning with a clinical history and physical examination, followed by in vivo testing and in vitro testing.
Allergy testing can be performed by in vivo or in vitro methods. In vivo testing involves a skin prick test (SPT), which is often the first-line approach to determine the release of allergen-specific IgE antibodies. However, in vitro testing with highly purified allergens or recombinants can be used as an alternative or complementary diagnostic tool.⁴
Using a small serum sample, the laboratory measures specific IgE antibodies to many different allergens.
In vitro specific IgE testing may be indicated over SPT:⁴,⁵
When the SPT test is negative but there is a high clinical suspicion
In patients with eczema
In patients taking tricyclic antidepressants
In very young or older patients who may have a reduced histamine response
In patients with an increased risk of anaphylaxis
In pregnant women
In vitro allergy blood testing supports improved patient outcomes:
Convenient method for monitoring decreases in sensitization resulting from a medical intervention such as allergen avoidance
Valuable diagnostic tool for following development and prognosis of sensitization in childhood
Convenient for patients suffering from eczema, atopic dermatitis, and other skin conditions
Practical for geriatric and pediatric patients affected by dermatographism
Convenient method for pediatric and geriatric patients
Easy to perform, with one simple blood draw to obtain multiple determinants
Reduced risk of anaphylaxis
No skin reactions
No need to stop patient’s medications, as there is no interference with medications such as antihistamine H1 blockers, H2 antagonists, or tricyclic antidepressants⁶
Good correlation with patient clinical history and skin tests⁷
Readily available to primary care physicians
The IMMULITE® 2000/XPi 3gAllergy™ – Allergen-specific IgE assay helps to enhance patient care with reliable results from a simple blood test that uses quality extracts thoroughly evaluated for potency and allergenic composition. The assay provides reliable results as an aid in the clinical diagnosis of IgE-mediated allergic disorders.
The 3gAllergy menu includes over 350 allergens, panels, and components across animals, drugs, dust, foods, grasses, insects, mites, molds, occupational, parasites, trees, and weeds.
Olert M, et al. Allergen-specific IgE measured by a continuous random-access immunoanalyzer: interassay comparison and agreement with skin testing. Clin Chem. 2005;51(7):1241. https://pubmed.ncbi.nlm.nih.gov/15905313/
The products/features mentioned here are not commercially available in all countries. Due to regulatory reasons, their future availability cannot be guaranteed. Please contact your local Siemens Healthineers organization for more details.