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Clinical Case Studies

Read the latest case studies featuring our customers stories and their clinical results using our innovative molecular imaging PET/CT and SPECT/CT scanners.
mi biograph vision 18f fdg pet ct

By Partha Ghosh, MD, Siemens Healthineers, Hoffman Estates, IL, USA
Data and images courtesy of Osaka City University Hospital, Osaka, Japan

18F FDG PET/CT delineation of diffuse large B-cell lymphoma involving lower spinal cord and spinal nerve roots

 15.02.2021

A 50-year-old female with progressive weakness in both legs underwent 18F FDG imaging performed on a Biograph VisionTM PET/CT scanner to evaluate a spinal pathology. This case illustrates how a comprehensive PET/CT evaluation helps delineate the extent of disease infiltration in primary central nervous system diffuse large B-cell lymphoma.

Clinical case study
SPECT/CT delineation of patellar and femorotibial overload after knee arthroplasty

By Christian Waldherr, MD and Partha Ghosh, MD
Data and images courtesy of Engereid Hospital, Bern, Switzerland

SPECT/CT delineation of patellar and femorotibial overload after knee arthroplasty

 31.07.2020

A 52-year-old woman with a history of right total-knee arthroplasty (TKA) presented with persistent right knee pain. An inconclusive radiograph led to a 99mTc-MDP three-phase bone scan, which was followed by SPECT/CT imaging to evaluate knee pathology.

 Clinical case study
Absolute quantification of 131I uptake in thyroid carcinoma metastases using xSPECT Quant for absorbed dose prediction

By Philipp Ritt, PhD, Torsten Kuwert, MD, Clinic of Nuclear Medicine, University Hospital Erlangen, Germany, and Partha Ghosh, MD, Siemens Healthineers, Hoffman Estates, IL, USA

Absolute quantification of 131I uptake in thyroid carcinoma metastases using xSPECT Quant for absorbed dose prediction

 18.06.2020

An 82-year-old female with a history of thyroid cancer presented with lesions on a chest CT regarded as suspicious for metastases. The patient underwent a diagnostic 131I scintigraphy performed on a Symbia IntevoTM SPECT/CT scanner. The case highlights the use of xSPECT Quant-based measurement to guide large-dose 131I therapy decisions.

xSPECT Quant, thyroid carcinoma metastasis, i 131 thyroid
Gap between prosthetic trochlear concavity and patellar articular margin suggesting slight lateral shift of patella

By Christian Waldherr, MD, and Partha Ghosh, MD
Data and images courtesy of Engereid Hospital, Bern, Switzerland

SPECT/CT in evaluation of anterior knee pain following patellofemoral arthroplasty

 03.06.2020

A 50-year-old man with a history of patella-femoral arthroplasty presented with persistent knee pain and underwent a 99mTc-DPD bone scintigraphy on a Symbia IntevoTM SPECT/CT scanner. The case highlights the use of bone SPECT/CT to accurately define the cause of post-arthroplasty pain when radiographic and CT findings are inconclusive.

SPECT/CT in evaluation of anterior knee pain following patellofemoral arthroplasty
MIP, coronal, and transverse MPR images show hypermetabolic right hilar lung mass and smaller hilar lesions on both sides

By Partha Ghosh, MD
Data and images courtesy of Chulabhorn Hospital & Research Institute, Bangkok, Thailand

Characterization of malignant lung lesions by whole-body parametric PET imaging

 09.05.2020

A 70-year-old man with squamous cell carcinoma of the lung underwent PET/CT imaging for initial staging performed with Fludeoxyglucose F 18 injection (18F FDG) on a Biograph Vision™. This case highlights the use of dynamic, whole-body imaging using the FlowMotion™ Multiparametric PET Suite to accurately define lung lesions.

Characterization of malignant lung lesions by whole-body parametric PET imaging
Increased tracer uptake in tibial component of medial right-knee hemi-arthroplasty

By Christian Waldherr, MD
Data and images courtesy of Engereid Hospital, Bern, Switzerland

Loosening of tibial component of knee arthroplasty with medial impression fracture defined by bone SPECT/CT

 31.03.2020

A 50-year-old man with persistent pain in the right-knee joint following a hemi-arthroplasty and subsequent total knee arthroplasty (TKA) underwent a 99mTc-DPD bone scintigraphy performed on a Symbia IntevoTM SPECT/CT scanner. The case highlights the use of SPECT/CT to define bone stress in symptomatic prosthetic knee joints.

 Clinical case study
xSPECT Quant-based dosimetry over four 177Lu DOTATATE therapy cycles for treatment of neuroendocrine tumor metastases

By Partha Ghosh, MD and Michal Cachovan, PhD
Data courtesy of Royal North Shore Hospital, Sydney, Australia

xSPECT Quant-based dosimetry over four 177Lu DOTATATE therapy cycles for treatment of neuroendocrine tumor metastases

 27.04.2019

A patient with a neuroendocrine tumor and multiple functioning liver metastases was referred for 177Lu DOTATATE, underwent an abdominal SPECT/CT study on a Symbia Intevo™ 6 utilizing xSPECT Quant™ technology. The case highlights the reliable value of quantitative SPECT/CT and 3D voxel-based dosimetry tools.

 Clinical case study
Nuclear cisternography in the detection of CSF leak

By Damita L. Thomas, MD
Data courtesy of University of Iowa Hospitals and Clinics, Iowa City, IA, USA

Nuclear cisternography in the detection of CSF leak

 18.04.2019

A 50-year-old woman reported progressively worsening headaches and neck pain. She underwent nuclear cisternography performed on Symbia Intevo™ following 99mTC DTPA administration. Excellent image quality on Symbia Intevo allowed for detection of small quantity CSF leaks.

nuclear cisternography
Evaluation of therapy response using sequential xSPECT Quant in a child with mediastinal neuroblastoma

By Mario Jreige, MD; Marie Nicod Lalonde, MD; Niklaus Schaefer, MD; John O. Prior, PhD, MD
Data courtesy of Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland

Evaluation of therapy response using sequential xSPECT Quant in a child with mediastinal neuroblastoma

 09.03.2019

A 7-year-old girl, diagnosed with stage IV mediastinal neuroblastoma with osteomedullary bone infiltration, underwent a follow-up 123I MIBG scintigraphy using Symbia Intevo™ with xSPECT Quant™ technology. The case highlights xSPECT Quant as a precise and objective tool for evaluating neuroblastoma patients.

xSPECT Quant
Evaluation of a retropharyngeal metastasis from papillary carcinoma of the thyroid

By Gustavo Gomez, MD
Data courtesy of Nucléos, Brasilia, Brazil

Evaluation of a retropharyngeal metastasis from papillary carcinoma of the thyroid

 02.03.2019

A 26-year-old female with a history of papillary carcinoma of the thyroid underwent large-dose 131I therapy. A post-therapy whole-body PET/CT scan on Biograph Horizon™ helped in the decision to continue 177Lu DOTATATE therapy.

Large-dose 131I, Whole-body PET/CT, 177Lu therapy
Erlanger head and neck PET/CT case study.

By Misty Long, R.T. (R)(N)
Data courtesy of Dr. Saima Muzahir, MD, Erlanger Health System, Chattanooga, TN, USA

PET/CT reveals recurrent disease in patients with head and neck cancers

 08.12.2018

An 84-year-old male with a more than 60 year history of tobacco use, previously diagnosed with squamous cell carcinoma of the oral cavity undergoes a PET/CT for subsequent treatment strategy with the aid of technologies like iMAR and FlowMotion™.

Clinical Results
A 68Ga PSMA study, performed on Biograph Vision, aides in the visualization of bladder invasion and pelvic lymph node metastases.

By Mario Jreige, MD; Marie Nicod Lalonde, MD; Niklaus Schaefer, MD; and John O. Prior, PhD, MD
Data courtesy of Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland

Detection of bladder invasion and pelvic lymph node metastases in a patient with primary prostate cancer

 29.11.2018

A 62-year-old man with primary prostate cancer, diagnosed on clinical examination and transrectal ultrasound, underwent 68Ga PSMA PET/CT for initial staging. The PET/CT study was performed on Biograph Vision™.

Clinical Results
A xSPECT Quant image quantifies a rib lesion on a SPECT/CT scan.

By Mario Jreige, MD; Patrick Omoumi, MD; John O. Prior, MD, PhD; and Marie Nicod Lalonde, MD
Data courtesy of Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland

Differentiation of a rib benign lesion from a metastasis using xSPECT Quant

 01.11.2018

A 58-year-old patient with prostatic hypertrophy underwent a prostatectomy, which led to an incidental discovery of adenocarcinoma of the prostate. After initial planar acquisitions were conducted, a subsequent SPECT/CT examination using xSPECT Bone™ and xSPECT Quant™ was administered for the thorax.

Clinical Results
A 68Ga PSMA study, performed on Biograph Vision, aides in the visualization of a solitary lymph node metastasis in a patient with primary prostate cancer.

By Walter Noordzij, MD, PhD; Ronald Borra, MD, PhD; and Partha Ghosh, MD
Data courtesy of University Medical Center Groningen, Groningen, The Netherlands

Detection of solitary pelvic lymph node metastasis in a patient with primary prostate cancer

 10.10.2018

A 78-year-old male with a medical history of lower urinary tract symptoms, referred for primary staging of his newly-diagnosed Gleason 3+4 prostate cancer, underwent a 68Ga PSMA PET/CT for initial staging on Biograph Vision™.

Clinical Results
Whole-body parametric PET imaging in metastatic lung cancer

By Damita L. Thomas, MD
Data courtesy of University of Tennessee, Knoxville, TN, USA

Whole-body parametric PET imaging in metastatic lung cancer

 06.10.2018

A 60-year-old woman with adenosquamous cell carcinoma of the lung underwent a dynamic whole-body PET scan on Biograph mCT Flow™ with FlowMotion™ Multiparametric PET Suite. Parametric imaging aided in the differentiation of post-procedural changes, which affected patient management.

Clinical case study