BN II System
Confidence in plasma protein results
The BN™ II System is an easy-to-use, reliable nephelometric analyzer that offers a broad range of protein assays. With assays available across multiple sample types, you can conveniently assess numerous disease states such as gammopathies, kidney diseases, neurology, and chronic alcohol abuse—on just one system.
- Designed for mid- to high-volume plasma protein throughput
- Broad menu from one source; more than 60 assay protocols available for determination of various sample types
- Up to 100 samples onboard
- Antigen-excess security for confidence in results
- Connectivity options to Aptio® Automation and FlexLab Automation solutions
- Assistance with clinical interpretation through our innovative range of assessment programs available for Protis® Data Management System1
Features & Benefits
As the first dedicated protein analyzer that can be connected to lab automation, the BN™ II System provides flexible options to meet the needs of the mid- to high-volume plasma protein lab. It uses nephelometric technology for protein determination and supports the clinical management of a variety of disease states, such as gammopathies, kidney diseases, neurology, and chronic alcohol abuse.
Increased workflow efficiency:
- Fully automated assay processing: from reading of sample tube bar codes to reporting of results
- Average throughput up to 130 tests per hour2, and its high onboard capacity of up to 100 samples and 35 reagents provides a walkaway time of more than 2 hours
- Wide measuring ranges enable fewer repeats
- User-friendly software facilitates easy operation
- Bidirectional host interface for convenient transfer of assay requests and results to the laboratory information system (LIS)
Flexible, efficient operation
- Continuous loading and reloading of samples and/or reagents without interrupting the system’s current workload
- Random-access processing eliminates sample batching
- Accommodates standard sample tubes as well as micro cups for low-volume samples, such as samples from pediatric patients
Confident, consistent results
- Confidence in results when analyzing samples with extremely high analytical concentrations
- Optimized reaction conditions and assay-specific, automated pre-reaction protocols ensure valid results without operator intervention
- Specimen level detection and positive barcode identification for samples, reagents, standards and controls to reduce human error
Improved workflow efficiency through automation
- Ability to connect to Aptio® Automation and FlexLab Automation solutions
- Interface module transfers sample tubes from the track into the BN II racks and pushes the racks onboard the analyzer
- Reduces manual interaction
- Extends walkaway capability
- Continuous access to reagents and consumables
- Enables manual loading of specialty samples, when needed
Innovative assay menu
- Broad menu available from one source; over 60 assay protocols for management of various clinical indications
- Routine and specialty assay consolidation
- Innovative markers including monoclonal kappa and lambda free light chains (FLC), cystatin C, beta-trace protein (BTP), and carbohydrate-deficient transferrin (CDT)
Enhanced result reporting with PROTIS System
- PROTIS® Assessment Software1 assists with interpretation support for a wide range of clinical indications
- PROTIS System data-management software manages online data transfer between the BN II System and LIS
- All data at a glance including graphical presentation of results, calculation of specific algorithms, and result interpretation suggestions modifiable by the user
Assays
Polyclonal and Monoclonal Gammopathies/ Immune System
β2-Microglobulin
FLC kappa
FLC lambda
Ig/Light Chain, type kappa
Ig/Light Chain, type lambda
IgA
IgG
IgG subclasses 1-4
IgM
Kidney Disease
α1-Microglobulin urine
α2-Macroglobulin urine3
β2-Microglobulin urine
β-trace protein3
Albumin urine
Cystatin C serum
FLC kappa urine
FLC lambda urine
Ig/Light Chain, type kappa urine3
Ig/Light Chain, type lambda urine3
IgG urine
NGAL3
Transferrin urine
Inflammation
α1-Acid Glycoprotein
High-Sensitivity CRP(CardioPhase® hsCRP)
Fibrinogen
SAA3
Autoimmune/Rheumatoid Diseases
ADNase B
ASL
C3c
C4
CRP
RF
Cardiovascular Risk/Acute Cardiac Care
Albumin urine
Apo A-I
Apo B
Cystatin C
Fibrinogen
High- Sensitivity CRP (CardioPhase® hsCRP)
Homocysteine
Lp(a)
Myoglobin
Chronic Alcohol Abuse
CDT
Transferrin (for %CDT calculation)
Allergic Diseases
IgE
Nutritional Assessment
Albumin
CRP
Ferritin
Prealbumin
RBP (retinol-binding protein)
Coagulation Disorders
AT-III
Fibrinogen
Plasminogen
Anemia/Iron Metabolism
Ferritin
Haptoglobin
Hemopexin
sTfR
Transferrin
Complement Activity
C1 Esterase Inhibitor
C3c
C4
Blood-CSF Barrier Dysfunction
Albumin
Albumin CSF
β-trace Protein3
FLC kappa CSF3
FLC lambda CSF3
IgA
IgA CSF
IgG
IgG CSF
IgM
IgM CSF
Other Specialty Analytes
α1-Antitrypsin
α2-Macroglobulin serum
Apo A-II3
Apo E3
Ceruloplasmin
Fibronectin3
Technical Specifications
Measuring principle | Nephelometry; measurement of the scattered light intensity in a fixed angle of 13 - 24 degrees |
Methods | More than 60 programmed assay protocols |
Sample throughput | Effective: Approx. 130 tests/hour depending on the assay mix Nominal: 225 tests/hour |
Analysis method | Fixed-time kinetics, end-point measurement, VLin Integral |
Calibration | Multi-point calibration |
Rack transport unit | Racks for up to 8 standard or control vials Racks for up to 7 reagent vials Racks for up to 10 sample tubes |
Dilution unit | 2 frames for max. 264 dilution cups |
Size of sample tubes | Diameter: 12 - 16 mm Height: 55 - 100 mm For pediatric samples: Conical microtubes with a maximum filling volume of 1.5 mL |
Barcode types | Automatic reading of different barcode types: 2/5 interleaved Codabar Code 39 Code 93 Code 128 |
Reagent volume | 40 µL reagent consumption on average |
Sample dilution | 1 : 1 to 1 : 40,000 |
Level detection | For samples, standards, controls, reagents, and system liquid containers |
Reaction cuvettes | 60 reusable cuvettes |
Measuring temperature | 37 ± 1.5°C |
Light source | Infrared high performance LED |
Wavelength | 840 ± 25 nm |
Detector | Photodiode with integrated pre-amplifier |
Instrument dimensions and weight | Analyzer dimensions (W x H with tubings x D) 124 x 92 x 63 cm (49 x 36 x 25 in.) Computer dimensions (W x H x D) Approx. 19.7 x 19.7 x 3.6 cm (7.8 x 7.8 x 1.4 in) Depth with keyboard Approx. 74 cm (29 in.)4 Printer dimensions (W x H x D) Approx. 41 x 27 x 37 cm (16 x 11 x 15 in.)4 Total bench length Approx. 230 cm (90 in.)4 Analyzer weight 150 kg (330 lb.) Terminal weight Approx. 7 kg (15.4 lb.)4 |
Room environment | Ambient temperature 15 to 32 °C (59 to 89 °F) Relative humidity Maintain between 30% and 85% (noncondensing) Average thermal output 340 BTU/hr (100 W) in standby mode 975 BTU/hr (286 W) in operating mode Water requirements Deionized water, NCClS Type 2 Microbial count must not exceed 100 CFU/ml |
Electrical installation requirements | Voltage 90–30 V 190–260 V Power consumption <140 VA (stand-by-mode) <400 VA (operating mode) Host interfacing Download and host-query mode |
Computer and Printer | Terminal Apple Mac mini Computer Printer Lexmark E260 D or DN or equivalent |
Connectivity | RS232 bi-directional host interface Aptio® Automation and FlexLab Automation solutions CentraLink® Data Management System |
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Related Products, Services & Resources
1. PROTIS Data Management System and PROTIS Assessment Software are not available for sale in the U.S.
2. Depending on the assay mix
3. Not available for sale in the U.S.
4. Dependent on model
The products/features (mentioned herein) are not commercially available in all countries. Due to regulatory reasons their future availability cannot be guaranteed. Please contact your local Siemens organization for further details.