Siemens Healthineers Hemostasis INNOVANCE Anti-Xa assay

INNOVANCE Anti-Xa assay

Simplify your anticoagulant testing with one streamlined, ready-to-use assay for heparin and direct oral anticoagulant (DOAC) testing

The INNOVANCE® Anti-Xa assay1 is an automated chromogenic assay for the quantitative determination of the activity of unfractionated heparin (UFH) and low-molecular-weight heparin (LMWH) as well as rivaroxaban and apixaban concentrations in citrated human plasma. The INNOVANCE Anti-Xa assay1 combines a truly ready-to-use liquid reagent for heparin and DOAC testing, allowing 24/7 access to rapid, specific testing for anticoagulants. Unlike most commercially-available solutions, this assay requires no manual preparation or waiting time.

Особливості

Stable reagents

Economical testing outcomes

  • Liquid reagents require no manual preparation or reconstitution, allowing staff to concentrate on high-value tasks.
  • Combined testing solution reduces handling, material, and ordering complexity for the lab.
  • Single calibration curve for both types of heparin (UFH and LMWH) streamlines result interpretation and eliminates the risk of evaluation on the wrong curve.
Stable reagents

Accelerate your lab's testing workflow

  • 24/7 access to rapid, specific testing for anticoagulants supports timely patient treatment.
  • Robust assay design reduces susceptibility to interferences.

Validated diagnostic

Consistent patient results over time

  • Drug-specific standards sets for the DOACs rivaroxaban and apixaban allow for accurate measurement of drug concentrations in ng/mL.
  • Broad and consistent assay range of 0.10 to 1.50 IU/mL for UF and LMW heparin
  • High lot-to-lot consistency that helps ensure consistent patient results over time

Технічні характеристики

The INNOVANCE Anti-Xa assay1 offers robust performance across all parameters. With its compact and ready-to-use configuration, the INNOVANCE Anti-Xa assay1 supports improved laboratory outcomes.It builds on the proven performance of the INNOVANCE Heparin assay and leverages the same proven components, but now also includes DOAC testing capabilities.

No waiting time
Liquid, ready-to-use reagent requires no manual preparation or standing time

0.10–1.50 IU/mL
Consistent measuring range for UFH and LMWH

20–350 ng/mL
Measuring range for rivaroxaban and apixaban

Up to 700 ng/mL

DOAC measuring range extendable by dilution

1.0%
Within-device/lab CV of INNOVANCE Heparin LMW Control 1

2.48%

Within-device/lab CV of INNOVANCE Apixaban Control 11

2.13%

Within-device/lab CV of INNOVANCE Rivaroxaban Control 11

8 weeks

Stability once opened at 2–8°C

By combining heparin and DOAC testing into one simple and easy-to-use assay, the INNOVANCE Anti-Xa assay1 streamlines handling, reduces order complexity, and offers labs an economical testing outcome.

    Siemens-Healthineers-Hemostasis-reagent-portfolio-cover

    For details on available assay applications or ordering information, download a copy of the hemostasis reagent portfolio catalogue.

    Клінічне використання

    Why your lab should perform anti-Xa testing for anticoagulants

    To monitor and manage bleeding risks, labs are asked to safeguard anticoagulant therapies such as heparin or direct oral anticoagulants (DOACs) by testing patients for a growing number of agents.

    Why accurate DOAC assessment is imperative

    Direct oral anticoagulants such as rivaroxaban and apixaban are direct anti-Xa inhibitor drugs that have evolved over time because of their convenient dosing and short half-life. Though the medication usually does not require monitoring, DOAC testing is needed to properly manage individuals with bleeding conditions, emergency situations that require unplanned surgery, and relevant comorbidities (e.g., renal insufficiency).

    Why anti-Xa is the better choice for heparin testing

    Heparin is a traditional anticoagulant drug and exists in two forms—UFH and LMWH—both of which considerably accelerate the inactivation of coagulation factor Xa by antithrombin. Clinical data shows that monitoring heparin with an anti-Xa assay has several advantages over APTT testing:2-6 

    •  A smoother dose-response curve 
    •  More-stable heparin levels during therapy 
    •  Fewer blood samples required 
    •  Fewer dosage adjustments

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