Percutaneous lung biopsy of a small metastatic nodule under CT guidance

Tobias Gassenmaier, MD
Department of Radiology and Nuclear Medicine, Luzerner Kantonsspital, Luzern, Switzerland

2024-04-09

A 61-year-old male patient, suffering from a renal cell carcinoma (RCC), underwent a CT examination for staging. A small lung nodule was detected, suspicious of a metastasis. The patient was admitted for a biopsy of the lesion under CT guidance.

A native chest CT was performed in the prone position for planning. The small lung nodule, measuring 6 × 8 mm in size, was shown in the left lower lobe, posterior basal segment (S10).

The patient was prepared under sterile conditions and local anesthesia using lidocaine. As the direct in-plane access was obstructed by a rib or the spine, due to the paravertebral location of the lesion, an angled approach from cranial was planned. A 17G coaxial needle with valve (to reduce the risk of pneumothorax or air embolism) was directed towards the pleura, using the entry point and the angle of the planned path projected by myNeedle Laser. The needle position was monitored and controlled by intermittent short sequential scans (i-sequence) and automatic multiplanar reformats (MPRs) reconstruction along the coaxial needle using automatic needle detection algorithm within myNeedle Guide 3D. This also calculated the distance between the needle tip and the lesion, guiding the advancement of the needle. Once the proper position of the coaxial needle was achieved, an 18G biopsy needle was inserted and a position check was repeated. This showed that the small round lesion was centrally captured. A punch biopsy with a 2 cm advancement was taken and the specimen was preserved in formalin. The instruments were removed with a blood patch during retraction.

In the control CT scan, immediately after the biopsy, signs of minor expected bleeding in the biopsy channel and blood in the access path after a blood patch were visible, with no evidence of a pneumothorax. The patient was asymptomatic and was transferred to the medical day ward for monitoring. Control imaging, 3 hours after intervention, using an ultra-low-dose chest CT protocol showed neither pneumothorax nor bleeding, allowing the patient to be discharged. The histological examination of the specimen confirmed a pulmonary metastasis from a renal cell carcinoma.

MPR images, reconstructed automatically along the coaxial needle in the intermittent control scans, show a 17G coaxial needle positioned close to the pleura and advanced to the nodule. The small nodule is centrally captured by an 18G biopsy needle. An AI-based needle detection algorithm automatically detects the position of the tip of the needle, calculates its distance to the nodule and projects a preview of the needle trajectory in-plane and off-plane.
Courtesy of Department of Radiology and Nuclear Medicine, Luzerner Kantonsspital, Luzern, Switzerland

Fig. 1: MPR images, reconstructed automatically along the coaxial needle in the intermittent control scans, show a 17G coaxial needle positioned close to the pleura /Fig. 1a & 1d) and advanced to the nodule (Fig. 1b & 1e). The small nodule is centrally captured by an 18G biopsy needle (Fig. 1c & 1f). An AI-based needle detection algorithm automatically detects the position of the tip of the needle (purple line), calculates its distance to the nodule (small circles) and projects a preview of the needle trajectory in-plane (solid green line) and off-plane (dotted green line).

An axial image acquired in a prone position for planning shows a small lung nodule in the left lower lobe. In the control CT scan immediately after the biopsy, dotted hyperdensities close to the nodule are visible representing minor bleeding in the biopsy channel and blood in the access path after a blood patch. No signs of pneumothorax are evident.
Courtesy of Department of Radiology and Nuclear Medicine, Luzerner Kantonsspital, Luzern, Switzerland

Fig. 2: An axial image acquired in a prone position for planning (Fig. 2a) shows a small lung nodule (arrow) in the left lower lobe (S10). In the control CT scan immediately after the biopsy (Fig. 2b), dotted hyperdensities close to the nodule are visible representing minor bleeding in the biopsy channel and blood in the access path after a blood patch. No signs of pneumothorax are evident.

A percutaneous lung biopsy guided by CT is a minimally invasive, established technique for histologically diagnosing pulmonary lesions, particularly effective for peripherally located lesions. Despite its efficacy, the procedure carries risks such as pneumothorax and intrapulmonary hemorrhage, potentially leading to longer hospital stays and increased costs. A precise planning of the needle trajectory and careful needle positioning are crucial to mitigate these risks. In this case, the procedure was conducted using the SOMATOM X.ceed, which incorporates an integrated laser system (myNeedle Laser) and 3D guidance (myNeedle Guide 3D). This advanced technology facilitates precise and efficient interventions. The myNeedle Laser projects the entry point and the angle of the planned path directly onto the patient's surface, aiding accurate needle insertion. The needle trajectory is shown automatically on MPRs, supporting off-plane, angulated procedures.

Throughout the biopsy, monitoring scans are performed to verify the needle position. The system employs an AI-based needle detection algorithm* that automatically aligns the MPRs with the detected needle, scrolls to the axial image at the needle tip, and provides a projected path preview. This graphical representation allows interventionists to evaluate whether the needle is on course or if adjustments are needed.

Integrating the laser guidance system with the automated needle detection algorithm not only enhances procedural efficiency but also potentially reduces radiation exposure by minimizing the need for frequent monitoring scans.

Scanner

Scan area

Thorax

Mid Thorax

Thorax

Scan mode

i-spiral mode
(planning)

i-sequence/i-spiral
(Planning/monitoring)

i-spiral mode
(control)

Scan length

344 mm

36/75.6 mm

343 mm

Scan direction

Cranio-caudal

Cranio-caudal

Cranio-caudal

Scan time

5.5 s

0.35/2 s

5.5 s

Tube voltage

120 kV

110/90 kV

90 kV

Effective mAs

106 mAs

38/95 mAs

134 mAs

Dose modulation

CARE Dose4D

CARE Dose4D

CARE Dose4D

CTDIvol

7 mGy

2.1/2.9 mGy

4 mGy

DLP

262 mGy*cm

3/28.8 mGy*cm

144 mGy*cm

Rotation time

0.5 s

0.5 s

0.5 s

Pitch

0.8

NA/0.8

0.8

Slice collimation

128 x 0.6 mm

128 x 0.6 mm

128 x 0.6 mm

Slice width

0.6 mm

0.6 mm

0.6 mm

Reconstruction increment

0.4 mm

0.4 mm

0.4 mm

Reconstruction kernel

Br36/Br60

Br36/Br60

Br36/Br60