Nonalcoholic steatohepatitis (NASH)

It is estimated that by 2030, NASH will be the #1 most frequent reason for liver transplants in the US. 

NASH is the more severe form of NAFLD in which you have hepatitis – meaning swelling or inflammation of the liver –– and liver cell damage, in addition to fat in your liver. Inflammation and liver cell damage can cause fibrosis, or scarring, of the liver. 


  • Obesity
  • Diabetes
  • High cholesterol
  • High triglycerides
  • People between the ages of 40 and 60
  • Have metabolic syndrome. This is a mix of conditions linked to being overweight or obese, and makes you more likely to get type 2 diabetes and heart disease. In order to be diagnosed with metabolic syndrome, any three of the following conditions must be present:
    • Large waist size
    • High blood pressure
    • High blood sugar (glucose)
    • High levels of triglycerides in your blood
    • Low levels of “good” (HDL) cholesterol in your blood

Those with Nonalcoholic Steatohepatitis (NASH) often go years without symptoms, meaning that the condition can remain undetected until the disease has already progressed to more serious stages. Early detection is one of the biggest challenges related to NASH diagnosis and management.2-3


Assessment of liver fibrosis has traditionally relied on costly and invasive liver biopsy that requires a specialist, may not be representative of the amount of fibrosis, and carries a risk of life-threatening complications.

  1. A true silent killer, liver disease often does not show signs or symptoms. 

  2. Many patients go undetected and remain in primary care.

  3. Complications of advanced fibrosis start to develop 

  4. Patient is then referred to a specialist by their PCP

  5. Patient finds out there is irreversible damage and/or is presenting with end stage liver disease

  6. More frequent assessment of prognosis was needed. The evolution of non-invasive liver fibrosis tests has created the opportunity to improve the risk assessment of disease progression helping to ensure patients get the care they need while reducing healthcare costs.

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