INNOVANCE Free Protein S Ag AssayIncrease efficiency in your thrombophilia testing

The INNOVANCE® Free Protein S Ag Assay is a liquid ready to use, highly specific, and stable test for the quantitative detection of free protein S in human plasma.

Features & Benefits

Stable reagents
  • Packaged in a simple two-component kit consisting of 4 reagent and buffer vial sets for convenience.
  • Onboard reagent stability up to 96 hours on Sysmex CS Systems and stability of up to 8 weeks once opened and stored at 2-8°C. This excellent stability reduces waste and cost, allowing even smallest labs to economically test for free protein S.

Fast turnaround time
  • Convenient liquid ready to use reagent requires no mixing or preparation, minimizing operator training requirements and hands-on time in the lab.
  • The assay provides turbidimetric detection of antibody/free protein S aggregates, delivering consistent, comparable performance across automated Siemens Healthineers hemostasis systems.

Validated diagnostic
  • The assay uses readily available standard human plasma calibrator calibrated against 2nd WHO International Standard for Protein S.
  • INNOVANCE Free Protein S Ag Assay is highly specific by design, detecting only the free form of protein S without cross-reactivity to PS/C4BP complexes (total PS)

Technical Specifications

Required sample volume, depending on system application

10-150% of norm
Measuring range on Sysmex CS-5100 System

96 hours
Onboard stability on Sysmex CS-5100 System

Within-device/lab CV(%) of Control plasma N on Sysmex CS-5100 System

152 tests per kit
Number of tests per kit configuration

8 weeks
Stability after reconstitution at 2-8°C

Clinical Use

GTH COVID-19 treatment recommendations

Protein S deficiency is a risk factor for thromboembolic diseases, although this is more clearly observed in thrombophilic families than in the general population. Protein S deficiency can be hereditary or acquired.

Current International Society of Thrombosis and Hemostasis (ISTH) recommendations consider the free protein S antigen (free PS Ag) assay to be the preferred initial test for protein S evaluation.1

Further, recently published data based on the ISTH evidence-based testing algorithm indicate 31- 60% cost savings can be achieved over other testing modalities.2

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