ADVIA 2400 Chemistry System
The right balance of speed and efficiency
The ADVIA® 2400 Clinical Chemistry System manages the most demanding workloads and meets high turnaround-time (TAT) goals. Its menu includes methods for testing drugs-of-abuse, therapeutic drugs (TDM) and new assays such as Cystatin C and CardioPhase® hsCRP. The ADVIA 2400 Clinical Chemistry System offers:
- High throughput of up to 2,400 tests/hour (1,800 photometric and 600 ISE) to manage heavy workloads
- Rapid, consistent 2-second cycle time for faster tube speed and test throughput
- User-defined automatic repeat, dilution, and reflex testing
- Large onboard reagent capacity and optional concentrated reagents help to minimize intervention demands
- Refrigerated onboard storage of controls and reagents for extended stability and increased productivity
- Automation ready design – no additional hardware required
ADVIA 2400 Chemistry System
Features & Benefits
The ADVIA® 2400 Clinical Chemistry System meets today’s high turnaround-time (TAT) goals with a throughput up to 2400 tests/hour. Besides assays for general and specialty chemistries, its menu includes assays for specific protein measurement, drugs-of-abuse testing (DAT) and therapeutic drug monitoring (TDM). Interesting new assays such as Cystatin C, HbA1c with automated sample pretreatment and CardioPhase® hsCRP can now be included into your routine testing.
The ADVIA 2400 Chemistry System pushes productivity levels while maintaining the reliability and stability that keep laboratories up and running. A rapid 2-second probe cycle time maximizes tube speed and test throughput, and combines with the system’s efficient automation-readiness to provide the turnaround time needed for high-volume laboratories
Superior Speed and Productivity
- Throughput of up to 2,400 tests/hour (1,800 photometric and 600 ISE) to manage the heaviest workloads
- Rapid, consistent 2-second cycle time
- Throughput of 200 tubes per hour even when running 3 ISE tests and 9 photometric tests per sample
- Automatic Sample Retain technology, auto-repeat, auto-dilution and auto-reflex testing
Automation Ready
- Point-in-space aspiration offers connectivity to a track or rack handler without robotics or special hardware
- Redundant sample loading for built-in backup and easy handling of non-routine samples
- Direct sampling from track prevents detaining tubes at analyzer and reduces aliquoting
Minimal Intervention Demands
- Minimal-maintenance ISEs
- Large onboard reagent capacity and optional concentrated reagents reduce interruptions
- No-maintenance 37°C incubation oil bath
- Auto-calibration and auto-QC from refrigerated onboard calibrators and controls
- Microvolume technology with 32,000 tests onboard and up to 60 days onboard stability improves walkaway time. Usage of concentrated reagents increases maximum capacity
- Remote diagnostics and ILQC (Inter-Laboratory Quality Control) options
Exceptional Reliability
- Sample integrity check for icterus, hemolysis and lipemia
- Sample probe with automatic clot/clog detection, liquid level sensing, short sample detection and crash protection
- Advances in reagent onboard stability, calibration frequency, interference reduction and assay linearity expansion
Assays
Diabetes
Fructosamine
Hemoglobin A1c (Enzymatic)
Drugs of Abuse/Toxicology
6-Acetylmorphine (6-AM)*
Acetaminophen
Amphetamines
Barbiturates, Urine
Barbiturates, Serum
Benzodiazepines, Urine
Benzodiazepines, Serum
Buprenorphine*
Cannabinoids (THC)
Cocaine Metabolite
Ecstasy
Ethyl Alcohol
Methadone
Methadone Metabolites
Opiates
Oxycodone*
Phencyclidine
Propoxyphene
Salicylate
Tricyclic Antidepressants
General Chemistry
Alanine Aminotransferase†
Alanine Aminotransferase (P5P)†
Albumin (BCG)†,‡
Albumin (BCP)
Alkaline Phosphatase (AMP)§
Alkaline Phosphatase (DEA)**
Ammonia
Amylase
Aspartate Aminotransferase†
Aspartate Aminotransferase (P5P)†
Bilirubin, Direct
Bilirubin, Total
Calcium (Arsenazo)†
Calcium (CPC)†
Carbon Dioxide (Enzymatic)§
Chloride
Cholesterol†
Cholinesterase
Creatine Kinase
Creatinine†
Creatinine (Enzymatic)
Gamma-Glutamyltransferase (GGT)
Glucose (Hexokinase)†
Glucose (Oxidase)†
HDL Cholesterol
Iron
Lactate
Lactate Dehydrogenase (L-P)
Lactate Dehydrogenase (P-L)
LDL Cholesterol
Lipase
Magnesium†
Microalbumin
Pancreatic Amylase
Phosphorus†
Potassium
Sodium
Total Iron Binding Capacity (TIBC)
Total Protein†
Total Protein, CSF/Urine
Triglycerides†
Urea Nitrogen (BUN)†
Uric Acid†
Specific Proteins
α1-Acid Glycoprotein
α1-Antitrypsin
Antistreptolysin O
Apolipoprotein A1
Apolipoprotein B
β-2 Microglobulin
Complement C3
Complement C4
CRP
CRP, High Sensitivity
CRP, Wide Range
Cystatin C
Ferritin
Haptoglobin
Immunoglobulin A
Immunoglobulin G
Immunoglobulin M
Lipoprotein(a)
Myoglobin
Prealbumin
Rheumatoid Factor
Soluble Transferrin Receptor (sTfR)**,††,‡‡
Transferrin
Therapeutic Drug Monitoring (TDM)
Carbamazepine
Digoxin
Gentamicin
Lithium
Methotrexate††,‡‡
Phenobarbital
Phenytoin
Theophylline
Tobramycin
Valproic Acid
Vancomycin
Validity Testing
Creatinine††,§§
Nitrite††,§§
Oxidant††,§§
pH††,§§
Specific Gravity††,§§
Technical Specifications
| Overview | |
|---|---|
| Type of System | Random, continuous access, batch, discrete processing |
| Throughput Rate | Up to 2400 tests/hour: 1800 tests/hour colorimetric, 600 tests/hour ISE |
| Assays Capacity Onboard | 49 including 3 ISE |
| Sample Handling | |
|---|---|
| Sample Tubes | 5 mL, 7 mL, 10 mL, 2 mL sample cups |
| Sample Tray | 84 samples, positive sample identification |
| Bar Codes | Interleaved 2 of 5, code 39, code 128, Codabar (NW7) |
| STAT Sample Loading | 84, not dedicated |
| Auto-repeat | Automatic repeat testing from the retained pre-diluted sample |
| Auto-dilution | Automatic dilution from retained pre-diluted sample |
| Auto-reflex Testing | Automatic ability to perform 3 additional tests based on results of first test |
| Primary Probe | Liquid Level Sensing, Crash Protection, Clot/Clog Detection, Short Sample Detection |
| Sample Integrity Check | Qualitative check for hemolysis, lipemia and icterus |
| Microvolume Technology | |
|---|---|
| Automatic Sample Predilution | Samples diluted 1:5 (30 μL sample + 120 μL saline generates up to 15 test results), retained for auto-repeat until results are available |
| Predilution Tray | 120 dilution cuvettes |
| Original Sample Volume | 2 to 30 µL; system uses an average of 2-3 µL per test |
| Average Reagent Volume | 80-120 µL per test |
| Storage Capacity Onboard | 20,000 tests average; Usage of concentrated reagents increases maximum capacity |
| Reaction Area | |
|---|---|
| Reaction Tray | 340 reusable plastic cuvettes |
| Cuvette Optical Path Length | 6 mm |
| Reaction Bath | Inert fluorocarbon oil circulation system, 37°C |
| Photometer | 14 fixed wavelengths (340, 410, 451, 478, 505, 545, 571, 596, 658, 694, 751, 805, 845, and 884 nm) |
| Light Source | 12V, 50W halogen lamp, cooled by forced water circulation |
| Assay Methods | Endpoint, rate reaction, 2-point rate, multi-point homogeneous immunoassay |
| Reaction Times | 3, 4, 5, 10, 15 and 21 minutes |
| Automatic Correction | Serum blank, cell blank, measurement point change, sample volume change in reassay |
| Point Forwarding | Automatically extends linerarity over assay range samples |
| Reagent Handling | |
|---|---|
| Reagent Tray | 2 trays, 50 positions each, refrigerated |
| Reagent Capacity Onboard | 46 colorimetric methods |
| Dispensing System | 2 probes with Liquid Level Sensing and Liquid Surface Verification |
| Reagent Wedges | 20, 40 and 70 ml bar-code-labeled wedges |
| Onboard Stability | Up to 60 days |
| Reagent Inventory Management | Tracks tests remaining, lot number, onboard stability and expiration date |
| Reagent Dilutions | Capability to dilute concentrated reagents onboard |
| Open System Capability | |
|---|---|
| Channels | 200 channels, includes user-defined applications |
| 3rd Party Applications | Varies by country, can be configured on system |
| ISE | |
|---|---|
| ISE | Indirect simultaneous measurement of Na+, K+, Cl- |
| Sample Volume | 22µL for all three tests |
| Priming | Automatic priming cycle |
| Electrode Life | 30,000 samples or 3 months |
| Throughput Rate | 600 tests/hour; 200 tubes/hour |
| Calibration/QC | |
|---|---|
| Calibration Interval | Up to 60 days, tracked by software |
| Auto-Calibration/Auto-QC | User-defined time interval or with new reagent wedge |
| View Calibration/QC Data | Graphical display of calibration curve and QC, Siemens Remote Service QC monitoring |
| Calibration/Control Tray | 61 refrigerated positions for calibrators, controls and diluents |
| Data Management | |
|---|---|
| Computer | Windows® XP, flat panel display |
| System Documentation | Operator manual and assays sheets on-line |
| Host Interface | RS 232C bidirectional |
| Data Storage | 70,000 patient samples |
| Onboard Maintenance Logs | Schedule and monitor routine maintenance activities via software |
| Host Query | ASCII; system requests work order or batch of work orders from host |
| General Specifications | |
|---|---|
| Power Requirements | 100/115/200/220/230/240 V +/– 10%, 30 A, 50/60 Hz, 3 KVA |
| Water Requirements | Deionized water |
| Maximum Water Consumption | 40 liters per hour |
| Drain requirements | Minimum of 10.6 gallons (40) liters per hour. |
| Dimensions | ADVIA 2400: 52.8 (h) x 67.4 (w) x 34.1 (d) in, 134 (h) x 171.1 (w) x 86.7 (d) cm |
| Weight | ADVIA 2400: 1,389 lbs. (630 kg) |
| Compliance | cUL, CSA, CE |
| Noise Specifications | Open cover less than 70 db, closed cover less than 45 db |
| Average Heat Output | 5,374 BTU/hour |
| Operating Temperature Range | 18° - 30°C/64° - 86°F |
| Ambient Humidity | 40% - 70% |
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Related Products, Services & Resources
* Alliance Application manufactured and distributed by Siemens Healthcare Diagnostics.
† Also available in concentrated version.
‡ ADVIA Chemistry XPT System supports concentrated version only.
§ Available only in concentrated version.
** Not available for sale in the U.S.
†† Not currently available on the ADVIA Chemistry XPT System.
‡‡ Alliance Application manufactured by third party, distributed by Siemens Healthcare Diagnostics.
§§ Syva application. Restricted in the U.S. to law enforcement-related use (forensic use only).
Due to local regulations, not all products are available in all countries.