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ADVIA 2400 Chemistry System

The right balance of speed and efficiency

ADVIA 2400 Chemistry System
ADVIA 2400 Chemistry System

    The ADVIA® 2400 Clinical Chemistry System manages the most demanding workloads and meets high turnaround-time (TAT) goals. Its menu includes methods for testing drugs-of-abuse, therapeutic drugs (TDM) and new assays such as Cystatin C and CardioPhase® hsCRP. The ADVIA 2400 Clinical Chemistry System offers:

    • High throughput of up to 2,400 tests/hour (1,800 photometric and 600 ISE) to manage  heavy workloads
    • Rapid, consistent 2-second cycle time for faster tube speed and test throughput
    • User-defined automatic repeat, dilution, and reflex testing
    • Large onboard reagent capacity and optional concentrated reagents help to minimize intervention demands
    • Refrigerated onboard storage of controls and reagents for extended stability and increased productivity
    • Automation ready design – no additional hardware required

    Features & Benefits

    The ADVIA® 2400 Clinical Chemistry System meets today’s high turnaround-time (TAT) goals with a throughput up to 2400 tests/hour. Besides assays for general and specialty chemistries, its menu includes assays for specific protein measurement, drugs-of-abuse testing (DAT) and therapeutic drug monitoring (TDM). Interesting new assays such as Cystatin C, HbA1c with automated sample pretreatment and CardioPhase® hsCRP can now be included into your routine testing.

    The ADVIA 2400 Chemistry System pushes productivity levels while maintaining the reliability and stability that keep laboratories up and running. A rapid 2-second probe cycle time maximizes tube speed and test throughput, and combines with the system’s efficient automation-readiness to provide the turnaround time needed for high-volume laboratories 

    Superior Speed and Productivity

    • Throughput of up to 2,400 tests/hour (1,800 photometric and 600 ISE) to manage the heaviest workloads
    • Rapid, consistent 2-second cycle time
    • Throughput of 200 tubes per hour even when running 3 ISE tests and 9 photometric tests per sample
    • Automatic Sample Retain technology, auto-repeat, auto-dilution and auto-reflex testing

    Automation Ready

    • Point-in-space aspiration offers connectivity to a track or rack handler without robotics or special hardware
    • Redundant sample loading for built-in backup and easy handling of non-routine samples
    • Direct sampling from track prevents detaining tubes at analyzer and reduces aliquoting

    Minimal Intervention Demands

    • Minimal-maintenance ISEs
    • Large onboard reagent capacity and optional concentrated reagents reduce interruptions
    • No-maintenance 37°C incubation oil bath
    • Auto-calibration and auto-QC from refrigerated onboard calibrators and controls
    • Microvolume technology with 32,000 tests onboard and up to 60 days onboard stability improves walkaway time. Usage of concentrated reagents increases maximum capacity
    • Remote diagnostics and ILQC (Inter-Laboratory Quality Control) options

    Exceptional Reliability

    • Sample integrity check for icterus, hemolysis and lipemia
    • Sample probe with automatic clot/clog detection, liquid level sensing, short sample detection and crash protection
    • Advances in reagent onboard stability, calibration frequency, interference reduction and assay linearity expansion

    Assays

    Diabetes
    Fructosamine
    Hemoglobin A1c (Enzymatic)

    Drugs of Abuse/Toxicology
    6-Acetylmorphine (6-AM)*
    Acetaminophen
    Amphetamines
    Barbiturates, Urine
    Barbiturates, Serum
    Benzodiazepines, Urine
    Benzodiazepines, Serum
    Buprenorphine*
    Cannabinoids (THC)
    Cocaine Metabolite
    Ecstasy
    EDDP††
    Ethyl Alcohol
    Ethyl Glucuronide (EtG)††,§§
    Fentanyl††
    Methadone
    Opiates
    Oxycodone*
    Phencyclidine
    Propoxyphene
    Salicylate
    Tramadol††

    General Chemistry
    Alanine Aminotransferase†
    Alanine Aminotransferase (P5P)†
    Albumin (BCG)†,‡
    Albumin (BCP)
    Alkaline Phosphatase
    Ammonia
    Amylase
    Aspartate Aminotransferase†
    Aspartate Aminotransferase (P5P)†
    Bilirubin, Direct
    Bilirubin, Total
    Calcium (Arsenazo)†
    Calcium (CPC)†
    Carbon Dioxide (Enzymatic)
    Chloride
    Cholesterol†
    Cholinesterase
    Creatine Kinase
    Creatinine†
    Creatinine (Enzymatic)
    Gamma-Glutamyltransferase (GGT)
    Glucose (Hexokinase)†
    Glucose (Oxidase)†
    HDL Cholesterol
    Iron
    Lactate
    Lactate Dehydrogenase (L-P)
    Lactate Dehydrogenase (P-L)
    LDL Cholesterol
    Lipase
    Magnesium†
    Microalbumin
    Pancreatic Amylase
    Phosphorus†
    Potassium
    Sodium
    Total Iron Binding Capacity (TIBC)
    Total Protein†
    Total Protein, CSF/Urine
    Triglycerides†
    Urea Nitrogen (BUN)†
    Uric Acid†

    Specific Proteins
    α1-Acid Glycoprotein
    α1-Antitrypsin
    Antistreptolysin O
    Apolipoprotein A1
    Apolipoprotein B
    β-2 Microglobulin
    Complement C3
    Complement C4
    CRP
    CRP, High Sensitivity
    CRP, Wide Range
    Cystatin C
    Ferritin
    Haptoglobin
    Immunoglobulin A
    Immunoglobulin G
    Immunoglobulin M
    Lipoprotein(a)
    Prealbumin
    Rheumatoid Factor
    Soluble Transferrin Receptor (sTfR)§,††
    Transferrin

    Therapeutic Drug Monitoring
    Carbamazepine
    Digoxin
    Gentamicin
    Lamotrigine††
    Levetiracetam††
    Lithium
    Methotrexate**,††
    Phenobarbital
    Phenytoin
    Theophylline
    Tobramycin
    Valproic Acid
    Vancomycin

    Validity Testing
    Creatinine*,§§
    Nitrite*,§§
    Oxidant*,§§
    pH*,§§
    Specific Gravity*,§§

    Technical Specifications

    Overview

    Type of System

    Random, continuous access, batch, discrete processing

    Throughput Rate

    Up to 2400 tests/hour: 1800 tests/hour colorimetric, 600 tests/hour ISE

    Assays Capacity Onboard

    49 including 3 ISE

    Sample Handling

    Sample Tubes

    5 mL, 7 mL, 10 mL, 2 mL sample cups

    Sample Tray

    84 samples, positive sample identification

    Bar Codes

    Interleaved 2 of 5, code 39, code 128, Codabar (NW7)

    STAT Sample Loading

    84, not dedicated

    Auto-repeat

    Automatic repeat testing from the retained pre-diluted sample

    Auto-dilution

    Automatic dilution from retained pre-diluted sample

    Auto-reflex Testing

    Automatic ability to perform 3 additional tests based on results of first test

    Primary Probe

    Liquid Level Sensing, Crash Protection, Clot/Clog Detection, Short Sample Detection

    Sample Integrity Check

    Qualitative check for hemolysis, lipemia and icterus

    Microvolume Technology

    Automatic Sample Predilution

    Samples diluted 1:5 (30 μL sample + 120 μL saline generates up to 15 test results), retained for auto-repeat until results are available

    Predilution Tray

    120 dilution cuvettes

    Original Sample Volume

    2 to 30 µL; system uses an average of 2-3 µL per test

    Average Reagent Volume

    80-120 µL per test

    Storage Capacity Onboard

    20,000 tests average; Usage of concentrated reagents increases maximum capacity

    Reaction Area

    Reaction Tray

    340 reusable plastic cuvettes

    Cuvette Optical Path Length

    6 mm

    Reaction Bath

    Inert fluorocarbon oil circulation system, 37°C

    Photometer

    14 fixed wavelengths (340, 410, 451, 478, 505, 545, 571, 596, 658, 694, 751, 805, 845, and 884 nm)

    Light Source

    12V, 50W halogen lamp, cooled by forced water circulation

    Assay Methods

    Endpoint, rate reaction, 2-point rate, multi-point homogeneous immunoassay

    Reaction Times

    3, 4, 5, 10, 15 and 21 minutes

    Automatic Correction

    Serum blank, cell blank, measurement point change, sample volume change in reassay

    Point Forwarding

    Automatically extends linerarity over assay range samples

    Reagent Handling

    Reagent Tray

    2 trays, 50 positions each, refrigerated

    Reagent Capacity Onboard

    46 colorimetric methods

    Dispensing System

    2 probes with Liquid Level Sensing and Liquid Surface Verification

    Reagent Wedges

    20, 40 and 70 ml bar-code-labeled wedges

    Onboard Stability

    Up to 60 days

    Reagent Inventory Management

    Tracks tests remaining, lot number, onboard stability and expiration date

    Reagent Dilutions

    Capability to dilute concentrated reagents onboard

    Open System Capability

    Channels

    200 channels, includes user-defined applications

    3rd Party Applications

    Varies by country, can be configured on system

    ISE

    ISE

    Indirect simultaneous measurement of Na+, K+, Cl-

    Sample Volume

    22µL for all three tests

    Priming

    Automatic priming cycle

    Electrode Life

    30,000 samples or 3 months

    Throughput Rate

    600 tests/hour; 200 tubes/hour

    Calibration/QC

    Calibration Interval

    Up to 60 days, tracked by software

    Auto-Calibration/Auto-QC

    User-defined time interval or with new reagent wedge

    View Calibration/QC Data

    Graphical display of calibration curve and QC, Siemens Remote Service QC monitoring

    Calibration/Control Tray

    61 refrigerated positions for calibrators, controls and diluents

    Data Management

    Computer

    Windows® XP, flat panel display

    System
    Documentation

    Operator manual and assays sheets on-line

    Host Interface

    RS 232C bidirectional

    Data Storage

    70,000 patient samples

    Onboard
    Maintenance Logs

    Schedule and monitor routine maintenance activities via software

    Host Query

    ASCII; system requests work order or batch of work orders from host

    General Specifications

    Power Requirements

    100/115/200/220/230/240 V +/– 10%, 30 A, 50/60 Hz, 3 KVA

    Water Requirements

    Deionized water

    Maximum Water Consumption

    40 liters per hour

    Drain requirements

    Minimum of 10.6 gallons (40) liters per hour.

    Dimensions

    ADVIA 2400: 52.8 (h) x 67.4 (w) x 34.1 (d) in, 134 (h) x 171.1 (w) x 86.7 (d) cm

    Weight

    ADVIA 2400: 1,389 lbs. (630 kg)

    Compliance

    cUL, CSA, CE

    Noise Specifications

    Open cover less than 70 db, closed cover less than 45 db

    Average Heat Output

    5,374 BTU/hour

    Operating Temperature Range

    18° - 30°C/64° - 86°F

    Ambient Humidity

    40% - 70%

    * Alliance Application manufactured and distributed by Siemens Healthcare Diagnostics.

    † Also available in concentrated version.

    ‡ ADVIA Chemistry XPT System supports concentrated version only.

    § Not available for sale in the U.S.

    ** Not currently available on the ADVIA Chemistry XPT System.

    †† Alliance Application manufactured by third party, distributed by Siemens Healthcare Diagnostics.

    §§ Syva application. Restricted in the U.S. to law enforcement-related use (forensic use only).

    ‡‡ Under development. Future availability cannot be guaranteed.

    Product availability may vary from country to country and is subject to varying regulatory requirements. Please contact your local representative for availability.