Tissue 4D

Tissue 4D is an advanced postprocessing platform for pharmacokinetic modelling of dynamic-contrast enhanced (DCE), perfusion-weighted MRI datasets.
It facilitates the intuitive visualization of regions of strong wash-in and wash-out in color-coded maps and allows the extraction of perfusion parameters from DCE MRI.
This might help in the detection of tumor tissues in organs such as the liver.

  • Standard curve evaluation
  • Curve evaluation according to a pharmacokinetic model

Características y Beneficios

Visualization features

4D visualization (3D and over time). Color display of parametric maps describing the contrast media kinetics such as:

  • Transfer constant, measure of capillary permeability (Ktrans)
  • Reflux constant (Kep)
  • Extra vascular extra cellular volume fraction (Ve)
  • Initial Area-Under-Curve (iAUC) for the first 60 seconds Additional visualization of 2D or 3D morphological dataset


Post-processing features

  • Elastic 3D motion correction
  • Fully automatic calculation of subtracted images


Pharmacokinetic model

Pharmacokinetic calculation on a pixel-by-pixel basis using a one-compartment model. Calculation is based on the Tofts model. Various model functions are available. Manual segmentation and calculation on the resulting images.


The following resulting images can be saved as DICOM images:

  • 3D motion-corrected, dynamic images
  • Colored images
  • Storage of calculated results
  • Export of results in the relevant layout format


General Requirements

  • Biograph mMR
  • MAGNETOM Altea
  • MAGNETOM Espree
  • MAGNETOM Lumina
  • MAGNETOM Prisma
  • MAGNETOM Sempra
  • MAGNETOM Skyra
  • MAGNETOM Spectra
  • MAGNETOM Symphony, A Tim System
  • MAGNETOM Trio, A Tim System
  • MAGNETOM Verio
  • MAGNETOM Amira
  • MAGNETOM Sempra
  • MAGNETOM Avanto
  • MAGNETOM Solafit
  • MAGNETOM Vidafit
  • MAGNETOM Prismafit
  • MAGNETOM Avantofit
  • MAGNETOM Skyrafit

syngo MR B17
syngo MMWP VE36A
syngo MR D11

Please Note: Additional technical pre-requisites may apply. Upon receiving your request, your local Siemens representative will clarify whether your system meets the requirements.