Sysmex CS-2500 SystemExcel with confidence in your hemostasis testing

The Sysmex® CS-2500 System—a fully automated coagulation analyzer—employs smartly designed technologies including assay-based preanalytical sample-quality checks using PSI™ technology, automated mixing studies, automated platelet aggregation,1 and clot waveform analysis2 for improved efficiency, exceptional accuracy, and reliable first-run results. Equipped with next-generation PSI technologies, the Sysmex CS-2500 System takes hemostasis testing to the next level and helps labs truly excel with confidence.

  • Assay-based preanalytical sample-quality checks that detect hemolysis, icterus, lipemia interference and underfilled primary-sample tubes to minimize retesting
  • Automated mixing studies, automated platelet aggregation,1 and clot waveform analysis2 for cost-effective instrument and staff consolidation
  • Unlimited potential for high-capacity performance with extended walkaway time
  • Operational efficiency via a wide spectrum of assay parameters, testing methodologies, and sophisticated software to simplify lab operations
  • Uninterrupted workflow delivered in a compact, affordable footprint
  • True lab-to-lab consistency for confident multisite patient monitoring

Features & Benefits

CS-2500 Cap piercer

Excel with simultaneous multiwavelength analysis and proven PSI technologies to minimize repeat testing and manual reviews.

  • Assay-based preanalytical sample-quality checks using PSI™ technology for HIL interference, primary-tube sample-volume checks and clog detection provide accurate and reliable results on the first run.
  • Simultaneous multiwavelength analytical scanning detects and manages unsuitable samples to minimize retests and reflex testing.
  • 10 flexible reaction detectors enable high-capacity performance for a variety of test profiles.
Excel with automated mixing

Excel with automated mixing studies, platelet aggregation,1 and clot waveform analysis2 for cost-effective instrument and staff consolidation.

  • Automated mixing studies help clinicians make decisions regarding factor deficiencies and circulating inhibitor patterns.
  • Automated platelet aggregation1 simplifies and automates assessment of inherited, acquired, or drug-induced platelet disorders.
  • Clot waveform analysis2 illustrates the optical reaction profile during PT or APTT measurement and provides qualitative and sensitive waveform patterns.
  • Intuitive user software simplifies operations with powerful, easy-to-use graphical analysis tools.
Reagent Table

Excel with unlimited potential for high-capacity performance and extended walkaway time.

  • Reagent capacity of up to 3000 tests,5 with onboard capacity of up to 40 reagents and five additional buffer positions.
  • Approximately 180 simultaneous PT/APTT tests/hour.3
  • Anti-evaporation caps and reagent table refrigerated at approximately 10⁰C maximize onboard reagent stability.
  • Tilted vials and SLD mini cups reduce reagent dead volume to maximize tests per vial.
CS-2500 traceability

Excel with operational efficiency via a wide spectrum of assay parameters, testing methodologies, and sophisticated software.

  • Optical methodology displays clot formation for evaluation of fragile clots.
  • Multidilution analysis (MDA), automated repeat, redilution, and reflex testing are consolidated on one platform.
  • 24-in. touchscreen and Windows 7-based software provide an easily customizable and user-friendly interface.
  • The system provides high test throughput using four measurement principles along with traceability of sample results and audit trails.
place samples

Excel with uninterrupted workflow delivered in a compact, affordable footprint.

  • Cap-piercing technology allows mix of capped and uncapped tubes and cups for dependable throughput.
  • Simultaneous processing of primary samples and micro mode for precious pediatric samples increase productivity.
  • Accessible reagent table provides continuous loading of reagents, consumables, and samples.
  • Automated QC checks are performed at user-defined intervals, and daily maintenance requires less than 5 minutes.
CS-2500 system true lab-to-lab consistency
  • Results correlate with the entire Sysmex CA and CS family of hemostasis systems.
  • Seamless integration of instruments, PSI technology, and assay reference ranges optimizes use across multisite labs.
  • Standardized software, reagents, controls, and calibrators improve convenience, offer cost savings, and reduce waste for more efficient utilization of labor.


The Sysmex® CS-2500 System offers an expansive test menu of routine and specialty hemostasis assays (including several INNOVANCE assays), all on a single instrument, allowing labs to run more tests per sample while processing a higher number of samples.

Dade® Innovin®
Thromborel® S

Dade Actin®
Dade Actin FS
Dade Actin FSL
Pathromtin® SL

Dade Thrombin

Thrombin time
Test Thrombin

Batroxobin time

Factor deficiency
Factor II
Factor V
Factor VII
Factor VIII
Factor IX
Factor X
Factor XI
Factor XII

Lupus anticoagulant
LA1 screening
LA2 confirmation

Protein C pathway
Protein C
ProC® AcR4
ProC Global4
F V Leiden
Protein S Ac
Protein S Ac

Berichrom® Heparin

Antithrombin III
Berichrom Antithrombin III (A)
INNOVANCE Antithrombin


Von Willebrand factor
vWF Ag
BC von Willebrand Reagent

Berichrom Factor VIII Chromogenic
Berichrom Factor XIII Chromogenic4
Berichrom C1-Inhibitor4
Berichrom α2-Antiplasmin
Berichrom Plasminogen
Berichrom Protein C

Arachidonic Acid4,6

Technical Specifications

  • Main unit:

     Approx. 775 (W) × 895 (D) × 685 (H) mm
     30.6 (W) × 35.2 (D) × 27.0 (H) in.

  • Pneumatic unit:

     Approx. 280 (W) x 355 (D) x 400 (H) mm
     11.1 (W) x 14.1 (D) x 15.7 (H) in.

  • Terminal (PC):

     Approx. 338 (W) x 381 (D) x 100 (H) mm
     13.3 (W) x 15.0 (D) x 3.95 (H) in.

  • Terminal (monitor):

     Approx. 556 (W) x 122.5 (D) x 403.5 (H) mm
     21.8 (W) x 4.8 (D) x 15.8 (H) in.

Measurement channels

  • 10 single channels for chromogenic, immunoassay, and aggregation methods
  • 10 wells (mixing function using stir bars possible for 4 wells)
  • Simultaneous five-wavelength photometry in all detector channels (340, 405, 575, 660, and 800 nm wavelengths)

Sample capacity

  • 50 samples; five racks with 10 samples per rack (maximum load)

Throughput (tests/hour)7

  • Approx. 180 PT
  • Approx. 180 APTT
  • Approx. 180 simultaneous PT/APTT
  • Approx. 95 simultaneous PT/APTT/AT/DD (results for normal-mode processing)


  • Access mode: continuous reagent-, consumable-, and sample-loading capability
  • STAT: five priority positions

Reaction tubes

  • Type: single reaction tubes
  • Loading: automatic continuous access, 500 reaction tubes onboard

Data storage

  • Approx. 10,000 samples with a maximum of 60 results per sample