Features & Benefits
Recommended screening method
A functional assay is the preferred screening method for detecting quantitative as well as qualitative defects of von Willebrand factor.2
Direct determination of VWF activity
The INNOVANCE VWF Ac assay1 directly determines activity of VWF. Due to the gain-of-function mutations, VWF binding to GPIb does not require ristocetin (VWF:GPIbM)3 and is therefore less susceptible to effects of certain polymorphism variants.
Excellent correlation to the gold-standard method
The INNOVANCE VWF Ac assay1 shows excellent correlation with the ristocetin cofactor-based BC von Willebrand assay.
Improved VWF testing workflow
The assay employs a liquid, ready-to-use reagent that requires no stirring.
Swipe through expert reviews to learn about their recent experiences
“The INNOVANCE® VWF Ac assay1 is reliable and precise with high sensitivity. The absence of ristocetin ensures result accuracy and minimizes the risk of misdiagnosis, especially in patients with a particular variant.”
MD, PhD, Professor of Pediatrics, Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf
Required sample volume on Sysmex® CS-2500 and CS-5100 Systems
4–600% of norm
Number of tests per kit
Assay performance can vary from country to country as well as corresponding to the system application of the respective assay. The values listed above are provided as examples only.
INNOVANCE VWF Ac kit1 components
The INNOVANCE VWF Ac assay1 is a turbidimetric, latex-based assay that employs a liquid, ready-to-use reagent. The assay consists of three components and can be ordered as a kit.
Description: Buffer with polystyrene particles coated with anti-GPIb monoclonal antibodies
Available on Siemens Healthineers and Sysmex Systems
INNOVANCE VWF Ac assay1 applications are available on Atellica COAG 3604 and BCS® XP Systems from Siemens Healthineers and Sysmex CN-3000/60004, CS-2500/5100 and CA-660 Systems. For details on ordering information and an overview of the current testing portfolio, download a copy of the hemostasis reagent catalog.
Using functional assays in the diagnosis and monitoring of von Willebrand disease
To correctly diagnose cases involving a bleeding anamnesis or a family history of von Willebrand disease and subsequently monitor patient response to therapy, physicians require a specific test for von Willebrand factor. A functional assay is the preferred screening method for detecting quantitative as well as qualitative defects of von Willebrand factor. For more details on VWD subtypes and management, recommended lab diagnostics, and the benefits of the INNOVANCE VWF Ac assay1, download the brochure.
INNOVANCE VWF Ac assay1 and vWF Ag assay4: a powerful combination
For the evaluation of von Willebrand disease, VWF activity assays can be combined with VWF antigen assays to detect and distinguish between quantitative and qualitative VWF deficiencies.2
The vWF Ag assay4 is an immunoturbidimetric assay that can be used on all Siemens Healthineers and Sysmex automated coagulation instruments. Explore the extended portfolio of analyzers and assays for the diagnosis of bleeding disorders and therapy monitoring.
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The INNOVANCE VWF Ac assay is under review by the FDA as a de novo classification request. An approval is pending and the product is not yet commercially available in the United States. Product availability may vary from country to country and is subject to varying regulatory requirements.
James PD, et al. ASH ISTH NHF WFH 2021 guidelines on the diagnosis of von Willebrand disease. 2021 Jan 12 [published online].
Bodo I, et al. Platelet dependent von Willebrand factor activity. Nomenclature and methodology:communication from the SSC of the ISTH. J Thromb Haemost 2015;13:1345–50.
Not available for sale in the U.S. Product availability may vary from country to country and is subject to varying regulatory requirements.
In the U.S., platelet aggregation testing is for research use only, not for use in diagnostic procedures.
Product availability may vary from country to country and is subject to varying regulatory requirements. Please contact your local Siemens Healthineers organization for further details.
Atellica, BCS, ADVIA, Berichrom, INNOVANCE, and all associated marks are trademarks of Siemens Healthcare Diagnostics Inc., or its affiliates. Sysmex is a trademark of Sysmex Corporation. All other trademarks and brands are the property of their respective owners.