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Clinical Case Studies

Read the latest case studies featuring our customers stories and their clinical results using our innovative molecular imaging PET/CT and SPECT/CT scanners.

By Andrés Ricaurte Fajardo, MD,1 Joseph Osborne, MD, PhD,1 Lady Sawoszczyk, BS, CNMT2
Data and images courtesy of New York-Presbyterian Hospital/Weill Cornell Medical Center, New York, New York, USA 

Fast, quantitative SPECT/CT acquisition following multiple therapy cycles of 177Lu-PSMA-617 enables response assessment in a patient with metastatic prostate cancer

 2023-03-13

A male in his 70s with a history of prostate-specific membrane antigen (PSMA)-positive metastatic castration-resistant prostate cancer (mCRPC) underwent routine 68Ga-PSMA-11 PET/CT imaging on Biograph mCT Flow™ PET/CT. 68Ga-PSMA-11 PET/CT findings confirmed PSMA expression in the metastatic disease, which qualified the patient for 177Lu-PSMA-617 treatment. The patient received 177Lu-PSMA-617 therapy followed by fast, multi-bed, quantitative SPECT/CT imaging after each treatment cycle. This clinical case demonstrates how Symbia Intevo Bold™ with xSPECT Quant™ enables 177Lu-PSMA-617 treatment response assessment.

Clinical case study

By Rene Fernandez, PhD and Vasko Kramer, MD
Data and images courtesy of Center for Nuclear Medicine & PET/CT Positronmed, Santiago, Chile

Tumor and organ dosimetry from sequential quantitative SPECT/CT
 2023-02-13

Three patients with metastatic prostate cancer underwent sequential, quantitative SPECT/CT on Symbia™ SPECT/CT following a single dose of albumin-bound 177Lu PSMA-ALB-56. This case series demonstrates the utility of sequential, quantitative SPECT/CT in obtaining accurate time activity curves (TACs) for subsequent dosimetry, which is of key importance for improving therapeutic outcomes while avoiding toxicity.

Clinical case study

By Parthiban Arumugam, MD and Yahya Al-Najjar, MD, Manchester Royal Infirmary, Manchester, United Kingdom
Data and images courtesy of Manchester Royal Infirmary, Manchester, United Kingdom

Delineation of multivessel coronary artery disease and post-therapy stent occlusion with 82Rb myocardial perfusion PET/CT and blood flow estimation

 2022-08-17

A 62-year-old female with atypical chest pain and a history of major factors for coronary artery disease (CAD) underwent a 82Rb PET/CT myocardial perfusion study on a Biograph Vision™ PET/CT scanner. This case demonstrates the value of 82Rb myocardial perfusion PET/CT and blood flow estimation in the delineation of multivessel CAD and post-therapy stent occlusion.

Clinical case study
PET MIP images show metastases vertex to thighs and help differentiate normal liver and 68Ga DOTATATE-avid metastases

By Partha Ghosh, MD, Siemens Healthineers, Hoffman Estates, Illinois, USA
Data and images courtesy of Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom

Detection of loosening of total knee arthroplasty prosthesis by 99mTc HMDP bone SPECT/CT using xSPECT Bone and xSPECT Quant with iMAR

 2022-08-17

An approximately 75-year-old female presenting with a history of bilateral total knee arthroplasty (TKA) and pain in both knees underwent a 99mTc HMDP bone study on Symbia Pro.specta™ SPECT/CT. This case highlights the clinical utility of xSPECT™ technologies with iterative metal artifact reduction (iMAR) in the detection of TKA prosthetic loosening.

Clinical case study

By Partha Ghosh, MD, Siemens Healthineers, Hoffman Estates, Illinois, USA
Data and images courtesy of Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom

Facet arthropathy along with fracture of spinal stabilization rod defined on 99mTc HMDP bone SPECT/CT in a patient with pain following thoracolumbar spinal fusion surgery

 2022-08-16

An approximately 75-year-old male with history of posterior spinal stabilization surgery and severe lower back pain underwent a 99mTc MDP bone study on Symbia Pro.specta™ SPECT/CT to determine the site of bone stress and related pathology. This case illustrates 99mTc MDP bone SPECT/CT imaging in the evaluation of pain following thoracolumbar spinal fusion surgery.

Clinical case study

By Partha Ghosh, MD, Siemens Healthineers, Hoffman Estates, Illinois, USA
Data and images courtesy of Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom

Localization of infection site in femoral stabilization pin using SPECT/CT with radiolabeled leukocytes

 2022-08-10

An approximately 70-year-old female with bilateral femoral intramedullary prostheses presenting with severe pain and slight wound discharge underwent a 99mTc HMPAO-labeled leukocyte study on Symbia Pro.specta™ SPECT/CT. This case demonstrates the value of using SPECT/CT with radiolabeled leukocytes and iterative metal artifact reduction (iMAR) in the evaluation of bony and prosthetic joint pathologies.

Clinical case study

By Partha Ghosh, MD, Siemens Healthineers, Hoffman Estates, Illinois, USA
Data and images courtesy of Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom

Sequential xSPECT Quant acquisitions for absorbed dose calculation following a therapy dose of 177Lu DOTATATE in a patient with a metastatic neuroendocrine tumor

 2022-07-25

An elderly male with a neuroendocrine tumor (NET) and liver metastases underwent sequential SPECT/CT on Symbia Pro.specta™ SPECT/CT following a therapy dose of 177Lu DOTATATE. This case demonstrates the value of using xSPECT Quant™ for the reproducible quantification of tracer concentration, which is instrumental for accurate dosimetry.

Clinical case study
PET MIP images show metastases vertex to thighs and help differentiate normal liver and 68Ga DOTATATE-avid metastases

By Partha Ghosh, MD, Siemens Healthineers, Hoffman Estates, IL, USA
Data and images courtesy of Inselspital, Bern, Switzerland

Single-bed, whole-body 68Ga DOTATATE PET/CT delineation of neuroendocrine tumor metastases

 2021-06-01

A 74-year-old male with a primary duodenal tumor underwent 68Ga DOTATATE PET/CT staging. This case demonstrates the role of the Biograph Vision Quadra™ in the evaluation of somatostatin-receptor density within neuroendocrine tumor metastases to help define metastatic burden and inform radionuclide therapy planning.

Clinical case study
VRT and MIP demonstrate hypermetabolic parenchymal foci, indicative of infectious or inflammatory process

By Misty Long, ARRT R.T.(R)(N), Siemens Healthineers, Hoffman Estates, IL, USA, and Lady Sawoszczyk, BS, CNMT,
NewYork-Presbyterian Hospital / Weill Cornell Medical Center, New York, New York, USA
Data and images courtesy of NewYork-Presbyterian Hospital / Weill Cornell Medical Center, New York, New York, USA

Incidental findings of COVID-19 in PET/CT imaging
 2021-04-12

A 75-year-old male with diffuse large B-cell lymphoma underwent PET/CT imaging on a Biograph mCT Flow™ scanner to assess residual disease. The patient was referred for COVID-19 testing due to suspicious hypermetabolic parenchymal foci in the lungs. This case reviews PET/CT in a differential diagnosis of COVID-19 within incidental findings.

Clinical case study
Axial CT and FDG PET/CT images show fluid along left breast prosthesis and mild FDG-avid left axillary and subpectoral nodes
By Kritika Subramanian, MD,1 Dunya Imad, MD,1 Ryan Pereira, CNMT,1 Lady Sawoszczyk, CNMT,1
Joseph Osborne, MD, PhD,1 Eleni Andreopoulou, MD,2 and Trisha Youn, MD1
Data and images courtesy of NewYork-Presbyterian Hospital / Weill Cornell Medical Center, New York, NY, USA

18F FES PET/CT imaging in recurrent metastatic invasive lobular breast cancer

 2021-04-08

A 75-year-old female with recurrent metastatic invasive lobular breast cancer underwent concurrent 18F FDG PET/CT and 18F FES PET/CT imaging to evaluate the extent of estrogen receptor (ER)-positive osseous lesions. This case highlights the use of 18F FES PET/CT in the evaluation of ER-positive breast cancer when 18F FDG PET/CT findings are inconclusive.

Clinical case study
By Partha Ghosh, MD, Siemens Healthineers, Hoffman Estates, IL, USA
Data and images courtesy of Chiba Aoba Municipal Hospital, Chiba, Japan
99mTc MDP SPECT/CT imaging in the evaluation of mandibular osteomyelitis severity
 2021-03-04

A 67-year-old female with chronic pain and limited movement in her right temporo-mandibular joint along with difficulty opening her jaw underwent a 99mTc MDP bone study on a Symbia Intevo™ SPECT/CT scanner. This case demonstrates the use of xSPECT Quant™ to help evaluate the severity of mandibular osteomyelitis.


Clinical case study
xSPECT Bone of knees shows punctate sclerosis in femur & tibia marrow corresponding to osteolysis in sclerotic foci

By Xuezhong Chen, MD, Jianbo Yang, MD, and Qing Zhang, MD
Data and images courtesy of Nanchang University, Nanchang, China

99mTc MDP SPECT/CT imaging in diagnosing Erdheim-Chester disease

 2021-03-04

A 47-year-old female with a history of progressive exophthalmos and bilateral orbital masses in the retro-ocular space underwent 99mTc MDP bone imaging with xSPECT Bone™ performed on a Symbia Intevo Bold™ SPECT/CT scanner. This case demonstrates the use of xSPECT Bone technology to help evaluate symmetrical bone metabolism when diagnosing Erdheim-Chester disease.

Clinical case study
By Wei Wang and Jigang Yang, Beijing Friendship Hospital of Capital Medical University, Beijing, China
Data and images courtesy of Beijing Friendship Hospital of Capital Medical University, Beijing, China

99mTc MDP SPECT/CT imaging in the evaluation of pediatric McCune-Albright syndrome

 2021-03-04

A seven-year-old female with café-au-lait skin spots, poly-fibrous dysplasia, and early on-set puberty underwent 99mTc MDP bone imaging with xSPECT Bone™ performed on a Symbia Intevo™ SPECT/CT scanner. This case demonstrates the use of xSPECT Bone™ technology to help detect abnormal skeletal metabolism in the evaluation of McCune-Albright syndrome.


Clinical case study
mi biograph vision 18f fdg pet ct

By Partha Ghosh, MD, Siemens Healthineers, Hoffman Estates, IL, USA
Data and images courtesy of Osaka City University Hospital, Osaka, Japan

18F FDG PET/CT delineation of diffuse large B-cell lymphoma involving lower spinal cord and spinal nerve roots
 2021-02-15

A 50-year-old female with progressive weakness in both legs underwent 18F FDG imaging performed on a Biograph Vision™ PET/CT scanner to evaluate a spinal pathology. This case illustrates how a comprehensive PET/CT evaluation helps delineate the extent of disease infiltration in primary central nervous system diffuse large B-cell lymphoma.

Clinical case study
SPECT/CT delineation of patellar and femorotibial overload after knee arthroplasty
By Christian Waldherr, MD and Partha Ghosh, MD
Data and images courtesy of Engereid Hospital, Bern, Switzerland
SPECT/CT delineation of patellar and femorotibial overload after knee arthroplasty
 2020-07-31

A 52-year-old woman with a history of right total-knee arthroplasty (TKA) presented with persistent right knee pain. An inconclusive radiograph led to a 99mTc-MDP three-phase bone scan, which was followed by SPECT/CT imaging to evaluate knee pathology.

 Clinical case study