ADVIA Centaur Vitamin D Total Assay

Siemens Healthcare Diagnostics offers a fully equimolar, automated total 25(OH)vitamin D (~100% D2 and D3) assay employing a proprietary monoclonal with minimal 1.1% 3-epi-25(OH)vitamin D3 cross-reactivity aligned to the ID-LC/MS/MS 25(OH)vitamin D Reference Measurement Procedure (RMP)2-3, the reference procedure for the Vitamin D Standardization Program (VDSP). Laboratories can meet increased testing demands by consolidating vitamin D testing on a fully automated, high-throughput immunoassay system.


  • Confidence in results through alignment to the 25(OH)vitamin D RMP2-3
  • Certified procedure of the CDC Vitamin D Standardization-Certification Program (VDSCP)1
  • Consistent and clinically accurate patient results with the equimolar total measurement of 25(OH)vitamin D2 and D3
  • Vitamin D can be combined with routine, stat, and specialty assays without compromising time – results are provided in 18 minutes with a throughput of 240 tests per hour
  • Proprietary monoclonal antibody provides lot-to-lot consistency
  • Reduced risk of confounding assessment with minimal cross-reactivity with 3-epi-25(OH)vitamin D3(1.1%)
  • A broad dynamic assay range (4.2–150 ng/mL) and on-board dilution – accommodates variety of patient results with minimal intervention.


  • Total measurement of 25(OH)vitamin D2 and D3
  • Good precision – 4.2% - 11.9% CV
  • Traceable to the ID-LC/MS/MS 25(OH)vitamin D RMP
  • Results in as little as 18 minutes (ADVIA Centaur® XP)

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Assay availability may vary from country to country and is subject to local regulatory requirements.

1CDC Vitamin D Standardization-Certification Program (VDSCP)—Total 25hydroxy Vitamin D Certified Procedures; 2017 Mar [cited 2017 Jun]. Available from:

2Sempos CT, Vesper HW, Phinney KW, Thienpont LM, Coates PM, Vitamin D Standardization Program (VDSP.) Vitamin D status as an international issue: National surveys and the problem of standardization.  Scandinavian Journal of Clinical & Laboratory Investigation, 2012; 72(Suppl 243): 32 -40

3Thienpont L, Stepman HCM, Vesper HW. Standardization of measurements of 25-Hydroxyvitamin D3 and D2. Scandinavian Journal of Clinical & Laboratory Investigation, 2012; 72(Suppl 243): 41 -49

The products/features (mentioned herein) are not commercially available in all countries. Due to regulatory reasons their future availability cannot be guaranteed. Please contact your local Siemens organization for further details.