ToRCH and Special ID AssaysSiemens Healthineers provides ToRCH and special infectious-disease assays for improved prenatal and specialty care.

ToRCH
ToRCH is an acronym for a group of infectious organisms, which in healthy individuals can lead to treatable and mild disease, but when acquired during pregnancy can cause significant birth defects and even fetal death. Therefore, recognizing maternal disease and monitoring the patient when diagnosed are important for clinicians treating patients. Understanding this group of illnesses can help clinicians counsel patients to prevent infection and address fetal outcomes if infected.

Toxoplasma
Other (Syphilis)
Rubella
Cytomegalovirus (CMV)
Herpes simplex virus (HSV)

Special Infectious Disease
Siemens Healthineers offers special infectious-disease (ID) assays* to help laboratories address critical and common infectious diseases and help clinicians make critical decisions. Siemens Healthineers offers the following special ID tests as part of a growing menu:

Epstein-Barr Virus (EBV) VCA IgG
Epstein-Barr Virus (EBV) VCA IgM
Epstein-Barr Virus (EBV) EBNA IgG
H. pylori IgG
Syphilis

Siemens Healthineers offers ToRCH and special ID testing assays for the Atellica® CI Analyzer, Atellica® IM Analyzer, ADVIA Centaur® Immunoassay Systems and IMMULITE® Immunoassay Systems.

Learn More about ToRCH

Understanding this group of illnesses can help clinician’s counsel their patients to help prevent infection, and address fetal outcomes if infected. Patient history and risk factors guide prenatal and maternal testing for ToRCH. These tests are often performed in the first trimester of pregnancy.

Assay Menu

Siemens Healthineers provides ToRCH and Special ID testing solutions for diagnostic laboratories with a comprehensive assay menu.

	Atellica® CI Analyzer	Atellica® IM Analyzer	ADVIA Centaur® XP/XPT Immunoassay Systems	IMMULITE® 2000/2000 XPi Immunoassay Systems
TORCH
Toxoplasma IgG	√	√	√	√
Toxoplasma IgM	√	√	√	√
Rubella IgG	√	√	√	√
Rubella IgM	√	√	√	√
CMV IgG	√	√	√	√
CMV IgM	√*	√^{^*}	√^*	√
Herpes-1 IgG	√^§	√	√
Herpes-2 IgG	√^§	√	√
Herpes I & II IgG				√
Special ID
Syphilis	√	√	√	√
EBV-EBNA IgG	√^§	√^§		√^*
EBV-VCA IgG	√^§	√^§		√^*
EBV-VCA IgM	√^§	√^§		√^*
H. pylori IgG				√

^* Not available for sale in the U.S.
^§ Under development. Future availability cannot be guaranteed.

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* System and assay availability is subject to local regulatory requirements.

^† Not available for sale in the U.S.

References:

1. Armstrong AS, Safford JW, Holbert DN, Mushahra IK. Congenital diseases of microbiological origin. In: Wood D, ed. The immunoassay handbook: applications. New York: Stockton Press; 1994:499-501.

2. Centers for Disease Control and Prevention. Genital Herpes—CDC Fact Sheet. http://www.cdc.gov/std/herpes/stdfact-herpes.htm. Updated February 19, 2016. Accessed September 8, 2016.

3. Wald A, Ashley-Morrow R. Serological testing for herpes simplex virus (HSV)-1 and HSV-2 infection. Clin Infect Dis. 2002;35(suppl 2):S173-S182.

4. Jenson HB, Baltimore RS. Infectious mononucleosis. Pediatric infectious diseases: principles and practice. Norwalk, Conn. Appleton & Lange, 1995: 565-76.

5. Henle W, Henle G. Epstein-Barr virus and infectious mononucleosis. In: Human herpesvirus infections: clinical aspects. New York: Marcel Dekker, 1982.

6. Gaffey MJ, Weiss LM. Association of Epstein-Barr virus with human neoplasia. Pathol Ann. 1992;27:55-74.

7. CDC Fact Sheet. https://www.cdc.gov/ulcer/files/hpfacts.pdf

8. https://www.cdc.gov/std/syphilis/stdfact-syphilis.htm

9. Musso D, Gubler DJ. Zika virus. Clin Microbiol Rev. 2016 Jul;29(3):487-524.

10. Petersen LR, Jamieson DJ, Powers AM, Honein MA. N Engl J Med. 2016 Apr 21;374(16):1552-63.

The products/features (mentioned herein) are not commercially available in all countries. Due to regulatory reasons their future availability cannot be guaranteed. Please contact your local Siemens Healthineers organization for further details.