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BN II System

Confidence in plasma protein results

 

 BN II System

The BN™ II System is an easy-to-use, reliable nephelometric analyzer that offers a broad range of protein assays. With assays available across multiple sample types, you can conveniently assess numerous disease states such as gammopathies, kidney diseases, neurology, and chronic alcohol abuse—on just one system.

  • Designed for mid- to high-volume plasma protein throughput
  • Broad menu from one source; more than 70 assay protocols available for determination of various sample types
  • Up to 100 samples onboard
  • Antigen-excess security for confidence in results
  • Connectivity options to Aptio® Automation and FlexLab Automation solutions
  • Assistance with clinical interpretation through our innovative range of assessment programs available for Protis® IT Solution1

Fonctionnalités et avantages

As the first dedicated protein analyzer that can be connected to lab automation, the BN™ II System provides flexible options to meet the needs of the mid- to high-volume plasma protein lab. It uses nephelometric technology for protein determination and supports the clinical management of a variety of disease states, such as gammopathies, kidney diseases, neurology, and chronic alcohol abuse.

Increased workflow efficiency:

  • Fully automated assay processing: from reading of sample tube bar codes to reporting of results
  • Average throughput up to 130 tests per hour2, and its high onboard capacity of up to 100 samples and 35 reagents provides a walkaway time of more than 2 hours
  • Wide measuring ranges enable fewer repeats
  • User-friendly software facilitates easy operation
  • Bidirectional host interface for convenient transfer of assay requests and results to the laboratory information system (LIS)

Flexible, efficient operation

  • Continuous loading and reloading of samples and/or reagents without interrupting the system’s current workload
  • Random-access processing eliminates sample batching
  • Accommodates standard sample tubes as well as micro cups for low-volume samples, such as samples from pediatric patients

Confident, consistent results

  • Confidence in results when analyzing samples with extremely high analytical concentrations
  • Optimized reaction conditions and assay-specific, automated pre-reaction protocols ensure valid results without operator intervention
  • Specimen level detection and positive barcode identification for samples, reagents, standards and controls to reduce human error

Improved workflow efficiency through automation

  • Ability to connect to Aptio® Automation and FlexLab Automation solutions
  • Interface module transfers sample tubes from the track into the BN II racks and pushes the racks onboard the analyzer
  • Reduces manual interaction
  • Extends walkaway capability
  • Continuous access to reagents and consumables
  • Enables manual loading of specialty samples, when needed

Innovative assay menu

  • Broad menu available from one source; over 70 assay protocols for management of various clinical indications
  • Routine and specialty assay consolidation
  • Innovative markers including monoclonal kappa and lambda free light chains (FLC), cystatin C, beta-trace protein (BTP), and carbohydrate-deficient transferrin (CDT)

Enhanced result reporting with PROTIS IT Solution

  • PROTIS® Assessment Software1 assists with interpretation support for a wide range of clinical indications
  • PROTIS IT Solution data-management software manages online data transfer between the BN II System and LIS
  • All data at a glance including graphical presentation of results, calculation of specific algorithms, and result interpretation suggestions modifiable by the user

Tests

Polyclonal and Monoclonal Gammopathies/ Immune System
β2-Microglobulin
FLC kappa
FLC lambda
Ig/Light Chain, type kappa
Ig/Light Chain, type lambda
IgA
IgD3
IgG
IgG subclasses 1-4
IgM

Kidney Disease
α1-Microglobulin urine
α2-Macroglobulin urine3
β2-Microglobulin urine
β-trace protein3
Albumin urine
Cystatin C serum
FLC kappa urine3
FLC lambda urine3
Ig/Light Chain, type kappa urine3
Ig/Light Chain, type lambda urine3
IgG urine
Transferrin urine

Inflammation
α1-Acid Glycoprotein
High-Sensitivity CRP(CardioPhase® hsCRP)
Fibrinogen
SAA3

Autoimmune/Rheumatoid Diseases
ADNase B
ASL
Calprotecin
C3c
C4
CRP
RF
TNFα Inhibitors (adalimumab, infliximab, etanercept)

Cardiovascular Risk/Acute Cardiac Care
Albumin urine
Apo A-I
Apo B
Cystatin C
Fibrinogen
High- Sensitivity CRP (CardioPhase® hsCRP)
Homocysteine
Lp(a)
Myoglobin

Chronic Alcohol Abuse 
CDT
Transferrin (for %CDT calculation)

Allergic Diseases 
IgE

Nutritional Assessment
Albumin
CRP
Ferritin
Prealbumin
RBP (retinol-binding protein)

Coagulation Disorders
AT-III
Fibrinogen
Plasminogen

Anemia/Iron Metabolism
Ferritin
Haptoglobin
Hemopexin
sTfR
Transferrin

Complement Activity
C1 Esterase Inhibitor
C1q3
C3 Proactivator3
C3c
C4
C53

Blood-CSF Barrier Dysfunction
Albumin
Albumin CSF
β-trace Protein3
FLC kappa CSF3
FLC lambda CSF3
IgA
IgA CSF
IgG
IgG CSF
IgM
IgM CSF

Other Specialty Analytes
α1-Antitrypsin
α2-Macroglobulin serum
Apo A-II3
Apo E3
Ceruloplasmin
Fibronectin3

Spécifications techniques

Measuring principle

Nephelometry; measurement of the scattered light intensity in a fixed angle of 13 - 24 degrees

Methods

More than 70 programmed assay protocols

Sample throughput

Effective: Approx. 130 tests/hour depending on the assay mix
Nominal: 225 tests/hour

Analysis method

Fixed-time kinetics, end-point measurement, VLin Integral

Calibration

Multi-point calibration

Rack transport unit

Racks for up to 8 standard or control vials
Racks for up to 7 reagent vials
Racks for up to 10 sample tubes

Dilution unit

2 frames for max. 264 dilution cups

Size of sample tubes

Diameter: 12 - 16 mm
Height: 55 - 100 mm
For pediatric samples:
Conical microtubes with a maximum filling volume of 1.5 mL

Barcode types

Automatic reading of different barcode types:
2/5 interleaved
Codabar
Code 39
Code 93
Code 128

Reagent volume

40 µL reagent consumption on average

Sample dilution

1 : 1 to 1 : 40,000

Level detection

For samples, standards, controls, reagents, and system liquid containers

Reaction cuvettes

60 reusable cuvettes

Measuring temperature

37 ± 1.5°C

Light source

Infrared high performance LED

Wavelength

840 ± 25 nm

Detector

Photodiode with integrated pre-amplifier

Instrument dimensions and weight

Analyzer dimensions (W x H with tubings x D)
124 x 92 x 63 cm (49 x 36 x 25 in.)
Computer dimensions (W x H x D)
Approx. 19.7 x 19.7 x 3.6 cm (7.8 x 7.8 x 1.4 in)
Depth with keyboard Approx. 74 cm (29 in.)4
Printer dimensions (W x H x D)
Approx. 41 x 27 x 37 cm (16 x 11 x 15 in.)4
Total bench length Approx. 230 cm (90 in.)4
Analyzer weight 150 kg (330 lb.)
Terminal weight Approx. 7 kg (15.4 lb.)4

Room environment

Ambient temperature 
15 to 32 °C (59 to 89 °F) 
Relative humidity 
Maintain between 30% and 85% (noncondensing) 
Average thermal output 
340 BTU/hr (100 W) in standby mode 
975 BTU/hr (286 W) in operating mode 
Water requirements 
Deionized water, NCClS Type 2 
Microbial count must not exceed 100 CFU/ml 

Electrical installation requirements

Voltage
90–30 V
190–260 V
Power consumption
<140 VA (stand-by-mode)
<400 VA (operating mode)
Host interfacing
Download and host-query mode

Computer and Printer

Terminal 
Apple Mac mini Computer
Printer 
Lexmark E260 D or DN or equivalent5

Connectivity

RS232 bi-directional host interface
Aptio® Automation and FlexLab Automation solutions
CentraLink® Data Management System

1

Product availability varies by country. PROTIS IT Solution is not available for sale in the U.S.

2

Availability varies by country. Not available for sale in the U.S.

3

Not available for sale in the U.S.

4

Dependent on model

5

Sold separately

The products/features (mentioned herein) are not commercially available in all countries. Due to regulatory reasons their future availability cannot be guaranteed. Please contact your local Siemens Healthineers organization for further details.