Cytokine Storm

Cytokine Storm Syndrome and Laboratory Testing

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Background

While most people with COVID-19 exhibit mild symptoms, approximately one in five develop severe pneumonia.1 Of severe COVID-19 patients, approximately 5% develop a systemic dysregulated cytokine response.1,2 This extreme immune response, called cytokine storm syndrome (CSS), is associated with severe COVID-19 disease and can cause widescale cellular and organ tissue damage.

The use of inflammation, tissue and organ damage biomarkers can help clinicians understand the severity of the disease and implement timely interventions for COVID-19 patients at risk for CSS.

Inflammation markers
IL-6IL-8
IL-1ßIL-2 R
TNF-αIL-10

High serum levels of pro- and anti-inflammatory cytokines were found in patients with severe COVID-19.3,4 IL-6 levels were higher in COVID-19 patients who did not survive.5

Tissue and organ damage markers, such as:
ALTPCT
ASTCREA
BILCYS C
LDHSAA
CRE KINCTNI
PT/INRCRP
D-DIMERFERR

Tissue and organ damage in patients with CSS can be monitored with a variety of laboratory tests.6

Siemens Healthineers has a robust menu of inflammatory markers (including a key marker, IL-6) and other lab tests to assess tissue and organ damage.

Educational Resources

cytokine-storm-syndrome-key-Inflammation-markers-infographic

Testing for Key Inflammation Markers


SARS-CoV-2-and-IL-6-illustration

Watch the webinar on demand today

Dr. Randy Cron discusses criteria for identifying cytokine storm syndrome (CSS) in patients, complications, and available potential treatments, which include glucocorticoids but also targeted therapies that dampen pro-inflammatory cytokines such as interleukin-1 (IL-1) and IL-6.

Speaker:
Randy Cron, MD, PhD
University of Alabama at Birmingham


covid-19-IL-6-MLO-article

Read the article at MLO

The authors cover the cause and symptoms of COVID-19 and how severe cases can relate to cytokine storm syndrome (CSS). Also discussed is IL-6† as a CSS biomarker and its potential predictive value for COVID-19 severity.


covid-19-image

View the educational presentation video

This video reviews a variety of COVID-19 and cytokine storm syndrome topics, including immune response to the SARS-CoV-2 virus from normal to extreme (CSS), the role of laboratory testing in detecting tissue damage caused by CSS, and how interleukin-6 (IL-6) potentially relates to COVID-19 severity.

Speaker:
H. Roma Levy, MS, Medical Writer
Siemens Healthineers

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