Rethink FFR assessment for every patient
Advanced solutions for Fractional Flow Reserve

FFR assessment
Rethink FFR assessment for every patient
 
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Cardiovascular diseases are the number 1 cause of death globally, taking an estimated 17.9 million lives each year1) – 52.5% of which are attributed to coronary heart disease.2) Consequently, related symptoms are taken very seriously: In patients with suspected coronary heart disease, the presence of a stenosis has to be verified, its extent assessed, and the need for revascularization determined.

Make confident decisions when assessing FFR

Accurately measure pressure differences across a stenosis, confidently assess its hemodynamic significance, and make confident decisions for all patients. From catheter-based Fractional Flow Reserve (FFR) assessment to image-based Angio-FFR3) and noninvasive CT FFR: Our portfolio has the right solution for every patient with coronary artery disease. Because as your partner for FFR, we are committed to supporting you in making competent decisions and improving patient outcomes by expanding precision medicine.

Discover our solutions for FFR assessment

View clinical cases of FFR assessments

Catheter-based FFR
Angio-derived FFR
CT-based FFR
Diastolic pressure ratio (dPR) case: Non-hyperemic pressure ratio with Sensis Vibe

Diastolic pressure ratio (dPR) case: Non-hyperemic pressure ratio with Sensis Vibe

Patient history:
  • 69-year-old patient with symptoms of angina pectoris
  • History of smoking (30 packs/year)
dPR measurement was performed in the RCA (dPR = 0.83)4)
Diastolic pressure ratio (dPR) case: Non-hyperemic pressure ratio with Sensis Vibe

Diastolic pressure ratio (dPR) case: Non-hyperemic pressure ratio with Sensis Vibe

Diagnostics:
Coronary angiography shows a stenosis of the RCA


Courtesy of University Hospital Erlangen, Erlangen, Germany
67-year-old male, BMI of 37

67-year-old male, BMI of 37: No known CAD

Cardiovascular risk factors:
  • Arterial hypertension
  • Smoking (40 packs/year)
  • No drug therapy

Courtesy of Klinikum Darmstadt, Darmstadt, Germany
67-year-old male, BMI of 37: No known CAD

67-year-old male, BMI of 37: No known CAD

Coronary one-vessel disease with stenosis of proximal LAD
(QCA: 62%)

Courtesy of Klinikum Darmstadt, Darmstadt, Germany
67-year-old male, BMI of 37: No known CAD

67-year-old male, BMI of 37: No known CAD

vFFR value: 0.74

Subsequent stent treatment necessary


Courtesy of Klinikum Darmstadt, Darmstadt, Germany
Benefit of including HeartFlow FFRCT Analysis in workup of patients with suspected coronary artery disease

Benefit of including HeartFlow FFRCT Analysis in workup of patients with suspected coronary artery disease

Patient history:
  • 73-year-old male
  • Checkup due to chest pain on exertion

Scan findings:
  • Calcified and noncalcified plaque in all three vessels
  • Moderate stenosis in LAD and LCX

Retrospectively analyzed with HeartFlow FRRCT Analysis

Courtesy of Medscan Barangaroo, Sydney, Australia
Benefit of including HeartFlow FFRCT Analysis in workup of patients with suspected coronary artery disease

Benefit of including HeartFlow FFRCT Analysis in workup of patients with suspected coronary artery disease

HeartFlow Analysis:
  • FFRCT in LCX distal to stenosis was 0.75
  • Nonsignificant FFRCT findings in RCA and LAD
Courtesy of Medscan Barangaroo, Sydney, Australia

Learn about scientific evidence for angio-derived FFR

Find out more about the current literature and proven facts regarding angio-derived FFR.

Discover our offering for FFR assessments

Do you want to perform catheter-based FFR, angio-derived FFR, or CT FFR? Our portfolio includes everything you need to accurately measure and assess pressure differences across a stenosis.

1) https://www.who.int/health-topics/cardiovascular-diseases/#tab=tab_1

2) https://www.who.int/gho/mortality_burden_disease/causes_death/top_10/en/
https://www.who.int/news-room/fact-sheets/detail/the-top-10-causes-of-death

3) Cases which can be evaluated with angio-derived FFR are stable coronary syndrome and non-ST elevation acute coronary syndrome.

4) Not commercially available in all countries.

5) Compared with usual care testing for patients with suspected CAD. Douglas PS et al. 1-Year Outcomes of FFRCT-Guided Care in Patients with Suspected Coronary Artery Disease. J Am Coll Cardiol. 2016;68(5):435-45.

6) Kornowski, R. et al. (2018): Online Angiography Image-Based FFR Assessment During Coronary Catheterization: A Single-Center Study, J Invasive Cardiol., 30(6), pp. 224-229, URL: https://www.ncbi.nlm.nih.gov/pubmed/29543186.

7) Kornowski, R. et al. (2016): Fractional Flow Reserve Derived From Routine Coronary Angiograms, JACC, 68(20), pp. 2235-2237, URL: https://www.sciencedirect.com/science/article/pii/S0735109716353086.

8) Westra, J. et al. (2018): Diagnostic Performance of In Procedure Angiography Derived Quantitative Flow Reserve Compared to Pressure Derived Fractional Flow Reserve: The FAVOR II Europe Japan Study, JAHA, 7(14), p. e009603, URL: https://www.ahajournals.org/doi/10.1161/JAHA.118.009603.

9) Westra, J et al. (2018): Evaluation of Coronary Artery Stenosis by Quantitative Flow Ratio During Invasive Coronary Angiography. The WIFI II Study (Wire-Free Functional Imaging II), Circ Cardiovasc Imaging, 11(3), pp. e007107, URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895131/pdf/hci-11-e007107.pdf.

10) Masdjedi, K. et al. (2019): Validation of 3-Dimensional Quantitative Coronary Angiography based software to calculate Fractional Flow Reserve: Fast Assessment of STenosis severity (FAST)-study, EuroIntervention, URL: https://www.ncbi.nlm.nih.gov/pubmed/31085504.

11) Daemen, J. et al. (2019): 100.54 Extended Validation of Novel 3-Dimensional Quantitative Coronary Angiography (3D-QCA) Based Software to Calculate Vessel Fractional Flow Reserve vFFR): The Fast Extend Study, JACC: Cardiovascular Interventions, 12(4), URL: http://interventions.onlinejacc.org/content/12/4_Supplement/S17.1.

12) Tomaniak, M. et al. (2019): TCT-331 Correlation Between 3D-QCA–Based FFR and Quantitative Lumen Assessment by IVUS for Left Main Coronary Stenoses: The FAST Left Main Study, JACC, 74(13), URL: http://www.onlinejacc.org/content/74/13_Supplement/B329.

13) Masdjedi, K. et al. (2018): Validation of novel 3-Dimensional Quantitative Coronary Angiography based software to calculate Vessel Fractional Flow Reserve (vFFR) post stenting: Fast Assessment of STenosis severity POST stenting, The FAST POST-study, presented at: TCT 2018, San Diego, CA.

14) Masdjedi, K. et al. (2019): TCT-110 The Prognostic Value of Angiography-Based Vessel-FFR After Successful Percutaneous Coronary Intervention: The FAST Outcome Study, JACC, 74(13), URL: http://www.onlinejacc.org/content/74/13_Supplement/B110.