VERSANT HIV-1 RNA 3.0 Assay (bDNA)
The VERSANT® HIV-1 RNA 3.0 Assay (bDNA) demonstrates excellent precision across the entire reporting range (variability range calculated from data in product inserts). The high level of precision afforded by branched DNA (bDNA) allows three-fold changes in viral load to be distinguished.1
Correlation with PCR
The VERSANT HIV-1 RNA 3.0 Assay (bDNA) demonstrated excellent correlation with the Roche COBAS AMPLICOR HIV-1 Monitor (PCR) Test, v.1.5 (Standard or UltraSensitive Processing Procedure). N=751 2
Minimizing the total cost of ownership in viral load testing through decreased hands-on time, reduced consumables and improved space utilization
The bDNA analyzer, the VERSANT 440 Molecular System, was compared to the predecessor System 340 for overall operational cost. The VERSANT 440 was able to significantly reduce costs and improve overall workflow.
- VERSANT 440 vigilance time (hands-on manipulations plus incubation time except initial target hybridization) was approximately 37% lower than the System 340 for HIV-1 and 64% for HCV bDNA3
- Disposables were approximately 12% and 31% lower for HIV-1 and HCV bDNA, respectively, with VERSANT 4403
- Biohazardous solid waste was approximately two-fold lower on the VERSANT 4403
Ease of Use
- Familiar ELISA-like format – Easy to learn and train
1 Amplicor HIV-1 Monitor Test v. 1.5, Standard and UltraSensitive procedures, U.S. IVD product insert; and VERSANT HIV-1 RNA 3.0 Assay (bDNA) U.S. IVD product insert.
2 Sherlock, C et al. 2003. Performance of the Bayer VERSANT HIV-1 RNA 3.0 Assay Compared with the Roche Cobas Amplicor HIV-1 Monitor™ v1.5 Assay with a Focus on Low Copy-Number Samples. 19th Clinical Virology Symposium poster.
3 Expert Rev Mol Diagn. 2007 Nov;7(6):713-22
'Cost assessment of the automated VERSANT 440 Molecular System versus the semi-automated System 340 bDNA Analyzer platforms.', Elbeik T, Loftus RA, Beringer S
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VERSANT HIV-1 RNA 3.0 Assay (bDNA) is for in vitro diagnostic use only by clinical professionals for the direct quantitation of HIV-1 RNA in plasma of HIV-1 infected individuals.
TaqMan and AMPLICOR are trademarks of Roche Molecrular Systems, Inc.
COBAS is a trademark of Roche Diagnostics Operations, Inc.