Dimension EXL Vitamin D Total Assay

Dimension EXL Vitamin D Total Assay
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Siemens Healthineers now offers a LOCI® Vitamin D Total assay on the Dimension® EXL™ Integrated Chemistry Systems. This assay enables laboratories to provide highly accurate total 25(OH) vitamin D results (~100% D2 and D3) with a fast turnaround time. Vitamin D testing can now be consolidated with routine testing on a fully automated, high-throughput integrated chemistry system.

  • Provides excellent sensitivity for more-accurate differential diagnosis of vitamin D insufficiencies and improved patient care.
  • Delivers fast turnaround time—31 minutes to first result.
  • Offers good reagent and calibration stability for improved operational and labor efficiency with less hands-on time.
  • Allows workload consolidation of routine and specialized tests for increased productivity. 


Demand for vitamin D testing continues to grow, prompted by emerging research on the importance of vitamin D to wellness. Recent studies show that globally, over one billion people are vitamin D-deficient2, and deficiency rates have increased as people have limited their sun exposure due to the risk of skin cancer.

Vitamin D deficiency has long been associated with rickets in children and osteomalacia in adults, and long-term insufficiency of calcium and vitamin D leads to osteoporosis. However, in recent years, vitamin D has become an assay of general health status, and there have been multiple publications linking vitamin D deficiency to several disease states, such as cancer, cardiovascular, diabetes, and autoimmune diseases3.

Measurement of total vitamin D can aid in the correct interpretation of patients’ overall health status.

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1 CDC Vitamin D Standardization-Certification Program (VDSCP) --Total 25hydroxy Vitamin D Certified Procedures; 2017 Mar [cited 2017 Jun]. Available from: https://www.cdc.gov/labstandards/pdf/hs/CDC_Certified_Vitamin_D_Procedures.pdf
2 Holick MF. Vitamin D deficiency. N Engl J Med. 2007;357(3):266-81.
3 National Institutes of Health, Office of Dietary Supplements. Dietary supplemental fact sheet: vitamin D. Updated 11/13/2009. Accessed 08/17/2010.