A vital leap forward in cardiac testing

Speed meets accuracy where it matters most―the wait is over for hs-cTnI at the point of care.

When lives are at stake and every second is crucial, how can clinicians get the answers they need quickly? Every lost second in the emergency department has the potential to affect patient outcomes. The Atellica® VTLi Patient-side Immunoassay Analyzer provides the vital information clinicians need to aid in making decisions about patient disposition.

When ruling out a potential myocardial infarction (MI), every minute spent waiting on test results comes at a cost. Patients and their families are anxious, and clinicians and laboratory professionals are pressured to identify the problem quickly and accurately. Increased time to results adds congestion to an already busy emergency department. But what if ED staff had access to high-sensitivity troponin right at the point of care? Consider the value of adding a new tool at the clinician’s disposal that can provide high-sensitivity troponin I (hs-cTnI) results in just 8 minutes from a single fingerstick and patient interaction. The solution is intuitive, easily integrates into the existing workflow, and gives laboratory partners centralized control over decentralized testing, so ED throughput can be improved for efficiency and confidence. 

The Atellica® VTLi Patient-side Immunoassay Analyzer, powered by Magnotech® Technology, will transform your chest pain assessment process to benefit patients, clinicians, and your operational workflow. Because when it comes to assessing patients with symptoms of an MI in the ED, trust, time, and resources aren’t just valuable—they’re vital. 


Dr. Fred Apple

"The Siemens Healthineers Atellica VTLi point-of-care assay technology, utilizing whole blood with result turn-around times in as fast as eight minutes, provides a high-sensitivity cardiac troponin I measurement that is equivalent to the diagnostic and analytical accuracy of instruments found in the central laboratory. I believe this POC system could easily integrate into existing hospital and clinic workflows, with the potential to impact patient care and clinical outcomes, with operational and financial efficiencies."

Dr. Fred Apple, PhD, Medical Director of clinical laboratories, clinical chemistry, point-of-care testing, and clinical and forensic toxicology laboratories at Hennepin County Medical Center. 

Population

99th URL (ng/L)

Timepoint

Subjects

Sensitivity
(95% CI)

Specificity
(95% CI)

PPV
(95% CI)

NPV
(95% CI)

Non-MI

MI

Overall

22.9

Baseline

998

91

64.8%
(54.6–73.9%)

85.7%
(83.4–87.7%)

29.2%
(25.0–33.8%)

96.4%
(95.3–97.2%)

2 hrs

998

91

81.3%
(72.1–88.0%)

84.6%
(82.2–86.7%)

32.5%
(28.7–36.4%)

98.0%
(97.0–98.7%)

Male

27.1

Baseline

615

56

67.9%
(54.8–78.6%)

86.2%
(83.2–88.7%)

30.9%
(25.5–36.9%)

96.7%
(95.3–97.7%)

2 hrs

615

56

80.4%
(68.2–88.7%)

84.7%
(81.7–87.3%)

32.4%
(27.6–37.5%)

97.9%
(96.5–98.8%)

Female

18.5

Baseline

383

35

65.7%
(49.2–79.2%)

85.4%
(81.5–88.6%)

29.1%
(22.6–36.6%)

96.5%
(94.5–97.7%)

2 hrs

383

35

82.9%
(67.3–91.9%)

84.3%
(80.4–87.6%)

32.6%
(26.8–38.9%)

98.2%
(96.3–99.1%)

Streamlined Patient Testing Workflow

Clinical Value of hs-cTnI

Cartridge Design

Troponin:
High-sensitivity vs. Contemporary

  1. Operator scans ID

    Operator scans ID

    • Sample type flexibility: The system can produce results on lithium-heparin whole blood, lithium-heparin plasma, and capillary samples.
    • Sample volume: minimum of 30 µL of blood required to perform the test.
    • Test results are sent securely through our POC Ecosystem™ Solution via WI-FI or Ethernet for storage in the LIS/HIS and EMR.

  2. Atellica VTLi Test resutls

    Compared with conventional troponin assays:

    • Higher NPV for AMI
    • Reduced “troponin-blind” interval, leading to earlier detection of AMI
    • Result in ~4% absolute and ~20% relative increases in the detection of type 1 MI and corresponding decrease in the diagnosis of unstable angina
    • Associated with 2-fold increase in the detection of type 2 MI

    Levels of hs-cTn are quantitative markers of cardiomyocyte damage:​

    • Elevations greater than 5 times the URL have high (90%) PPV for acute type 1 MI.​
    • Elevations up to 3 times the URL have limited (50–60%) PPV for AMI.​
    • It is common to detect circulating levels of cardiac troponin in healthy people.

    Rising and/or falling cardiac troponin levels differentiate acute from chronic cardiomyocyte damage.

  3. Reagent cartridge top view

    Reagent cartridge top view

    The cartridge is disposable (single-use) and specific for one or more assays, with no warm-up time from refrigerated storage.

    Each disposable cartridge is identified by a unique Radio Frequency identification (RFID) chip, that contains information on the type of test, calibration data, and lot-specific information.

    • Instructs the instrument to automatically starts the correct assay protocol
    • Integrated assay quality control in every cartridge

  4. NDA Atellica Cardiac Chart
    • Contemporary assays must detect cTn in 20% to <50% of healthy individuals.
    • High-sensitivity assays must detect cTn in at least 50% of healthy individuals and must have <10% CV at the 99th percentile of normal.
    • Units of measure:
      • Contemporary: ng/mL
      • High-sensitivity: ng/L

Screenshot of the self test on analyzer
Test Utilization 

  • Software version/validity
  • Electronic system 
  • Temperature control system 
  • Storage space 
  • Imaging system 
  • Analyzer orientation 
  • Battery level 
  • Magnetic system

POC Atellica VTLi Cartridge
Cartridge Validation

  • RFID version/validity
  • Cartridge use data
  • Light intensity reference 
  • Cartridge type 
  • Cartridge alignment 
  • No sample added 
  • Expiry date Optical image quality

POC Atellica VTLi Dispensing Blood Capillary
Sample Application 

  • Sample application 
  • Cartridge filling time 
  • Sample volume check

Test results are available within 8 minutes after sample application.
Test Execution 

  • Analyzer cap closed 
  • Cartridge temperature 
  • Dynamic readout 
  • Power button disabled 
  • Light intensity 
  • Cartridge movement 
  • Analyzer orientation/shock

1

2