Arterial Spin Labeling
Non-contrast quantitative perfusion assessment


Arterial Spin Labeling (ASL) is an MR technique using the water in arterial blood as an endogenous contrast agent to non-invasively evaluate perfusion. ASL is available as a 2D EPI sequence (ASL 2D) and as a 3D GRASE sequence (ASL 3D). ASL 2D includes inline calculation of relCBF maps for a quantitative evaluation of perfusion. ASL 3D includes an inline calculation of perfusion-weighted maps for a qualitative evaluation of perfusion. Clinical applications of ASL include acute stroke, evaluation of Transient Ischemic Cerebral Attack (TIA), chronic cerebrovascular disease, degenerative diseases like Alzheimer’s disease and frontotemporal dementia, evaluation of brain tumors, functional evaluation of the brain with BOLD techniques or intervention planning.

Clinical Benefits of Multi-PLD PCASL in Pediatric Patients with Moyamoya Disease

Aya Tominaga et al., Miyagi Children’s Hospital, Sendai, Japan

Perfusion Imaging in Pediatric Brain Tumors: Pseudo-continuous Arterial Spin Labeling at Work

Giovanna Stefania Colafati et al., Department of Imaging, Neuroradiology Unit, Bambino Gesù Children’s Hospital, Rome, Italy

ASL perfusion imaging: Clinical experience in patients with cerebrovascular steno-occlusive disease

Toshibumi Kinoshita, et al., Department of Radiology and Nuclear Medicine, Research Institute for Brain and Blood Vessels-Akita, Akita, Japan

Brain perfusion imaging in a case of thalamic stroke: a clinical application of 3D PCASL

Fabrizio Esposito, Ph.D. et al., Department of Medicine, Surgery and Dentistry, Scuola Medica Salernitana, University of Salerno and Department of Diagnostic Imaging, University Hospital San Giovanni di Dio e Ruggi D’Aragona, Scuola Medica Salernitana, Salerno, Italy

Cerebral blood flow measurements in elderly using arterial spin labeling at 3T

Peter J. Joris, Ph.D. et al., Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands

3D ASL Perfusion: Biomarker of Activity in Japanese Encephalitis

Babu Peter Sathyanathan, M.D., D.N.B
Barnard Institute of Radiology, Madras Medical College, Chennai, India

Further readings

Contrast-free Quantitative CBF and Bolus Arrival Time using Multi-delay ASL Perfusion MRI

Qiao Penggang, et al., Department of Radiology, Affiliated Hospital of the Academy of Military Medical Sciences, Beijing, China

A novel 2D Pulsed Arterial Spin Labeling Protocol for Pediatric Cases with Brain Tumor

Yang Wang, M.D. et al., Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA

Arterial Spin Labeled Perfusion MRI

John A. Detre, M.D. Center for Functional Neuroimaging, Department of Neurology and Radiology, University of Pennsylvania, Philadelphia, PA, USA

Listen to the talks

Brain perfusion – acquisition and evaluation

Heiko Meyer, Siemens Healthineers, Erlangen, Germany
8th MAGNETOM World Summit, 2012

Clinical Applications of Arterial Spin Labeling

John A. Detre, University of Pennsylvania, Philadelphia, PA, USA
6th MAGNETOM World Summit, 2008

WIP, the product is currently under development and is not for sale in the US and in other countries. Its future availability cannot be ensured.