Emit II Plus Oxycodone Assay
Enabling early detection of pain prescription abuse

Emit II Plus Oxycodone Assay
Emit II Plus Oxycodone Assay
 
Nous contacter

The Centers for Disease Control and Prevention estimates that the total economic burden of prescription opioid misuse alone in the United States is $78.5 billion a year, including the costs of healthcare, lost productivity, addiction treatment, and criminal justice involvement.1

Oxycodone is a semisynthetic opioid analgesic prescribed for the relief of moderate to severe pain. Oxycodone structurally resembles codeine and morphine, with similar analgesic properties and potential for addiction and abuse. Oxycodone is a DEA schedule II drug. The drug oxycodone is prescribed in controlled-release form (OXYCONTIN), or in combination with acetaminophen (PERCOCET) or with aspirin (PERCODAN).

Features & Benefits

The Emit II Plus Oxycodone assay offers 100 ng/mL and 300 ng/mL cutoffs and no cross-reactivity to structurally related compounds such as buprenorphine and hydrocodone.

  • Achieve high specificity for oxycodone and oxymorphone to provide confidence for accurate results while meeting the SAMHSA requirements for oxycodone screening
  • Reduce false results with an assay that has 98% agreement to LC-MS/MS for positive samples and 100% agreement for negatives.1
  • Consolidate opioid testing with other Siemens Healthineers assays, enabling providers to screen patients on one trusted system

Technical Specifications

EMIT II Plus Oxycodone Assay Performance*

Assay PrincipleHomogeneous enzyme immunoassay
Sample TypeUrine
Sample Volume12 µL (100 ng/mL)
4 µL (300 ng/mL)
Assay Range50—400 ng/mL (100 ng/mL cutoff)
75—1000 ng/mL (300 ng/mL cutoff)
Reagent StabilityStable unopened or opened until exp., when stored refrigerated at 2–8°C
Cutoff Level100 ng/mL and 300 ng/mL
Calibration Range0—1000 ng/mL
Levels0, 100, 300, 500, 1000 ng/mL
Limit of Detection29 ng/mL (100 ng/mL cutoff)
44 ng/mL (300 ng/mL cutoff)
Cutoff Overlap Precision0% overlap between cutoff and ±25% controls
Onboard Reagent Stability4 weeks
Calibration FrequencyAs indicated by QC results

 

1Florence CS, Zhou C, Luo F, Xu L. The Economic Burden of Prescription Opioid Overdose, Abuse, and Dependence in the United States, 2013. Med Care. 2016;54(10):901-906. doi:10.1097/MLR.0000000000000625.
*Future availability cannot be guaranteed