Syva Specimen Validity Testing

Specimen Validity TestingTreatment starts with a test

A drug-testing program will only be successful if it accurately detects people who have used drugs. If someone thinks they may test positive on an upcoming drug test, they may attempt to cheat to obtain a negative result. There are a few ways in which people attempt to do this, but certain measures can be taken to detect sample tampering and/or prevent it from happening. Specimen validity tests determine whether a urine specimen has been adulterated, diluted, or substituted to obtain a negative result, or is invalid.

In addition to our extensive Syva® drugs-of-abuse testing menu, Siemens Healthineers offers five specimen validity tests to help you determine if you are testing a valid urine sample.

Tests are available on the Atellica® CH Analyzer, ADVIA® Chemistry Systems, and the Viva™ Drug Testing Systems.

Watch this educational video to hear more about specimen validity testing with Siemens Healthineers.

Test Name



Expected Values



Jaffe, alkaline picrate

Diluted ≥2 mg/dL and <20 mg/dL
(specific gravity >1.0010 and <1.0030)

Substituted <2 mg/dL (specific gravity ≤1.0010)
OR <2 mg/dL (specific gravity ≥1.020)

Invalid <2 mg/dL (specific gravity >1.0010 and <1.0200)
OR ≥2 mg/dL (specific gravity ≤1.0010)



Indicator: diazonium salt complex

Adulterated ≥500 µg/mL

Invalid ≥200 µg/mL


Oxidizing agents

Substituted benzene reaction

Adulterated ≥50 µg/mL (chromium VI)



Dye indicator

Adulterated <4 OR ≥11

Invalid ≥4 and <4.5 OR ≥9 and <11

Specific gravity

Specific gravity

Dye indicator

Diluted >1.0010 and <1.0030 (creatinine ≥2 and <20)

Substituted ≤1.0010 (creatinine <2)
OR ≥1.0200 (creatinine <2)

Invalid >1.0010 and <1.0200 (creatinine <2)
OR ≤1.0010 (creatinine ≥2)