- Troponins are a family of proteins found in all striated muscle that serve to help the muscle contract
- Troponin controls myofibril contraction
- Troponin is released when the cardiac cells die after a period of ischemia causing the AMI
- Individual cardiac troponin components are found as a cytosolic free pool
- Troponin elevation is not specific for acute myocardial infarction (AMI) – several pathologies can result in cardiac damage
Collinson PO, Gaze DC. Med Princ Pract. 2007;16:247-61. Amsterdam EA, et al. Circulation. 2014;130:e344-426; Thygesen K, et al. Eur Heart J. 2012; 33:2551-67
IFCC Guidelines for High-Sensitivity Troponin assays1
- High-Sensitivity refers to the assay’s performance characteristics, not a difference in the form of cardiac troponin being measured
- %CV at the 99th percentile should be ≤10%
- Measureable concentrations below the 99th percentile should be attainable with a concentration above the assay’s LoD for at least 50% of healthy individuals
Apple F., Sandoval Y., Jaffe A., and Ordonez-Llanos J. Cardiac Troponin Assays: Guide to Understanding Analytical Characteristics and Their Impact on Clinical Care. Report of the IFCC Task Force on Clinical Applications of Cardiac Biomarkers. Clinical Chemistry 63:01 (2016) ; Product availability varies by country
Reasons to use a High-Sensitivity Troponin I Assay
- Increasing sensitivity of cTn assays enables detection of smaller areas of necrosis
- Optimize negative predictive value: high-sensitivity troponin allows for a more rapid triage of patients suspected of AMI based on improved discrimination of low level troponin I concentrations at presentation as well as over time.
- For early presenters: low-end precision allows early detection of significant change in troponin I concentrations, which may not have yet exceeded the 99th percentile limit.
- Serial sampling strategies are still recommended!
- They may be shortened with hsTNI assays based on published guidelines
ADVIA Centaur XP/XPT and Atellica IM High-Sensitivity Troponin I Intended Use Statement
The ADVIA Centaur XP/XPT (TNIH) and Atellica IM (TnIH) High-Sensitivity Troponin I assays are available for in vitro diagnostic use in the quantitative measurement of cardiac troponin I in human serum or plasma using the following instruments:
- ADVIA Centaur® XP
- ADVIA Centaur XPT
- Atellica® IM systems
These assays can be used to aid in the diagnosis of acute myocardial infarction (AMI).
Overview and Clinical Guidelines
View the Overview and Clinical Guidelines section of this website for detailed specifications on Siemens Healthineers High-Sensitivity Troponin I assay.
Take a look behind the design of Siemens Healthineers new High-Sensitivity Troponin I assay and learn why it provides fast, accurate and actionable test results – in this informative video.
Animation and Infographic
Watch the troponin animation to learn more about cardiac troponins, testing, and guidelines, and the role of this critical biomarker for earlier acute myocardial infarction (AMI) diagnosis.
Download the one-page Understanding Myocardial Infarction infographic for additional details on AMI.