Summary: Preanalytical factors influencing the reliability of laboratory test results are commonplace. It is traditionally accepted that hemolyzed samples are unsuitable for coagulation assays because of the release of hemoglobin, intracellular components, and thromboplastic substances from damaged blood cells. The complexity of coagulation reactions and the sophistication of coagulation analytical methods render coagulation testing among the most prone to pre-analytical errors in the clinical laboratory. Hemolysis and under-filling tubes are two of the most common reasons for rejecting specimens. Furthermore, the incidence of hemolysis has increased with the decentralization of phlebotomy practices to non-laboratory personnel.
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