- High specificity for 6-Acetylmorphine (6-AM)
- No cross-reactivity to morphine, morphine metabolites, and common analgesics
- Qualitative (10 ng/mL cut-off) and semi-quantitative results
- Low analytical sensitivity of 1.1 ng/mL*
- >99% agreement with the reference method (GC/MS)

EMIT II Plus 6-Acetylmorphine Assay
Accurately screen for heroin use
The EMIT® II Plus 6-Acetylmorphine Assay accurately detects heroin use, without cross-reactivity to morphine, morphine metabolites, and many common analgesics. Siemens offers a convenient and effective way to selectively test for heroin use and enables your laboratory to adjust to changing testing requirements.
Features & Benefits
Maintain a high level of integrity in your drug testing program, with the addition of the Emit® II Plus 6-Acetylmorphine Assay to your current offering.
Over the past decade, the number of heroin confiscations has more than doubled.1 Furthermore, an increasing amount of morphine-type drugs are prescribed as analgesics that can cross-react with traditional opiate assays.
Can a rapid screen differentiate heroin use from prescribed or ‘over-the-counter’ medications?
The presence of the heroin metabolite 6-Acetylmorphine (6-AM) in urine specifically confirms the use of heroin. The new EMIT II Plus 6-Acetylmorphine Assay is intended for the qualitative and semi-quantitative determination of 6-AM in human urine, at a cut-off value of 10 ng/mL. This new assay meets the Substance Abuse and Mental Health Services Administration (SAMHSA) guidelines for Federal Workplace Testing.
The EMIT® II Plus 6-Acetylmorphine Assay provides:
- High specificity for 6-Acetylmorphine (6-AM)
- No cross-reactivity to morphine, morphine metabolites, and common analgesics
- Qualitative (10 ng/mL cut-off) and semi-quantitative results
- Low analytical sensitivity of 1.1 ng/mL*
- >99% agreement with the reference method (GC/MS)
- Rapid results: 11 minutes to first result
- Convenient dual calibrator/control with the EMIT II Plus Ecstasy Assay
Applications are available for Siemens’ Viva-Jr®, Viva-E®, and V-Twin® Drug Testing Systems, the Dimension® and Dimension Vista®, as well as a variety of other general chemistry analyzers.
1. World Drug Report 2009, United Nations Office on Drugs and Crime (UNODC)
*Analytical sensitivity of 1.1 ng/mL on Vital Systems.
Technical Specificiations
EMIT II Plus 6-Acetylmorphine Assay Performance
Assay Principle | Homogeneous Enzyme Multiplied Immonoassay (EMIT) |
Cut-off | 10 ng/mL |
Assay range | 0-20 ng/mL |
Sample | Urine |
Reagent Stability | Unopened until expiration date; Opened working reagent, 4 weeks |
Calibration Frequency | Based on control results |
Qualitative Precision (mA/min)
| Level | Mean | Repeatability |
| Within-Lab |
|
|
| (ng/mL) | SD | %CV | SD | %CV |
Control 1 | 7.5 ng/mL | 558 | 1.5 | 0.3 | 7 | 1.3 |
Cut-off | 10.0 ng/mL | 591 | 1.7 | 0.3 | 6.5 | 1.1 |
Control 2 | 12.5 ng/mL | 622 | 1.7 | 0.3 | 6 | 1 |
Semi-quantitative Precision (ng/mL)
| Level | Mean | Repeatability | Within-Lab |
|
|
|
| (ng/mL) | SD | %CV | SD | %CV |
Control 1 | 7.5 ng/mL | 8.7 | 0.12 | 1.4 | 0.43 | 5.1 |
Cut-off | 10.0 ng/mL | 11.3 | 0.14 | 1.5 | 0.48 | 4.2 |
Control 2 | 12.5 ng/mL | 14.2 | 0.16 | 1.1 | 0.5 | 3.5 |
Assay Specificity
Concentrations of compounds that produce negative results vs. the 10 ng/mL cut-off
Compounds Concentration Tested | (ng/mL) |
Buprenorphine | 1,000,000 |
Codeine | 500,000 |
Dextromethorphan | 100,000 |
Dihydrocodeine | 500,000 |
Heroin | 80 |
Hydrocodone | 300,000 |
Hydromorphone | 100,000 |
Imipramine | 200,000 |
Levorphanol | 100,000 |
Meperidine | 800,000 |
Morphine | 100,000 |
Morphine-3-Glucuronide | 600,000 |
Morphine-6-Glucuronide | 600,000 |
Nalorphine | 100,000 |
Naloxone | 300,000 |
Naltrexone | 300,000 |
Norcodeine | 600,000 |
Normophine | 100,000 |
Oxycodoen | 400,000 |
Oxymorphone | 100,000 |
Ordering information
9R129UL | EMIT® II Plus 6-Acetylmorphine Assay, large | R1=1000 mL and R2=500 mL |
9R039UL | EMIT II Plus 6-Acetylmorphine Assay, small | R1=28 mL and R2=14 mL |
9A509UL | EMIT Calibrator/Control Level 0 | 14 mL |
9R529UL | EMIT II Plus 6-AM/Ecstasy Calibrator/Control Level 1 | 10 mL |
9R549UL | EMIT II Plus 6-AM/Ecstasy Calibrator/Control Level 2 | 10 mL |
9R569UL | EMIT II Plus 6-AM/Ecstasy Calibrator/Control Level 3 | 10 mL |
9R589UL | EMIT II Plus 6-AM/Ecstasy Calibrator/Control Level 4 | 10 mL |
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* Analytical sensitivity of 1.1 ng/mL on the Viva-Jr®, Viva-E®, and V-Twin® Drug Testing Systems.
The products/features (mentioned herein) are not commercially available in all countries. Due to regulatory reasons their future availability cannot be guaranteed. Please contact your local Siemens Healthineers organization for further details.