EMIT II Plus 6-Acetylmorphine AssayAccurately screen for heroin use

The EMIT® II Plus 6-Acetylmorphine Assay accurately detects heroin use, without cross-reactivity to morphine, morphine metabolites, and many common analgesics. Siemens offers a convenient and effective way to selectively test for heroin use and enables your laboratory to adjust to changing testing requirements.

High specificity for 6-Acetylmorphine (6-AM)
No cross-reactivity to morphine, morphine metabolites, and common analgesics
Qualitative (10 ng/mL cut-off) and semi-quantitative results
Low analytical sensitivity of 1.1 ng/mL*
>99% agreement with the reference method (GC/MS)

Features & Benefits

Maintain a high level of integrity in your drug testing program, with the addition of the Emit® II Plus 6-Acetylmorphine Assay to your current offering.

Over the past decade, the number of heroin confiscations has more than doubled.¹ Furthermore, an increasing amount of morphine-type drugs are prescribed as analgesics that can cross-react with traditional opiate assays.

EMIT® II Plus 6-Acetylmorphine Assay - Features & Benefits

Can a rapid screen differentiate heroin use from prescribed or ‘over-the-counter’ medications?

The presence of the heroin metabolite 6-Acetylmorphine (6-AM) in urine specifically confirms the use of heroin. The new EMIT II Plus 6-Acetylmorphine Assay is intended for the qualitative and semi-quantitative determination of 6-AM in human urine, at a cut-off value of 10 ng/mL. This new assay meets the Substance Abuse and Mental Health Services Administration (SAMHSA) guidelines for Federal Workplace Testing.

The EMIT® II Plus 6-Acetylmorphine Assay provides:

High specificity for 6-Acetylmorphine (6-AM)
No cross-reactivity to morphine, morphine metabolites, and common analgesics
Qualitative (10 ng/mL cut-off) and semi-quantitative results
Low analytical sensitivity of 1.1 ng/mL*
>99% agreement with the reference method (GC/MS)
Rapid results: 11 minutes to first result
Convenient dual calibrator/control with the EMIT II Plus Ecstasy Assay

Applications are available for Siemens’ Viva-Jr®, Viva-E®, and V-Twin® Drug Testing Systems, the Dimension® and Dimension Vista®, as well as a variety of other general chemistry analyzers.

1. World Drug Report 2009, United Nations Office on Drugs and Crime (UNODC)
*Analytical sensitivity of 1.1 ng/mL on Vital Systems.

Technical Specificiations

EMIT II Plus 6-Acetylmorphine Assay Performance

Assay Principle	Homogeneous Enzyme Multiplied Immonoassay (EMIT)
Cut-off	10 ng/mL
Assay range	0-20 ng/mL
Sample	Urine
Reagent Stability	Unopened until expiration date; Opened working reagent, 4 weeks
Calibration Frequency	Based on control results

Qualitative Precision (mA/min)

	Level	Mean	Repeatability		Within-Lab
		(ng/mL)	SD	%CV	SD	%CV
Control 1	7.5 ng/mL	558	1.5	0.3	7	1.3
Cut-off	10.0 ng/mL	591	1.7	0.3	6.5	1.1
Control 2	12.5 ng/mL	622	1.7	0.3	6	1

Semi-quantitative Precision (ng/mL)

	Level	Mean	Repeatability	Within-Lab
		(ng/mL)	SD	%CV	SD	%CV
Control 1	7.5 ng/mL	8.7	0.12	1.4	0.43	5.1
Cut-off	10.0 ng/mL	11.3	0.14	1.5	0.48	4.2
Control 2	12.5 ng/mL	14.2	0.16	1.1	0.5	3.5

Assay Specificity

Concentrations of compounds that produce negative results vs. the 10 ng/mL cut-off

Compounds Concentration Tested	(ng/mL)
Buprenorphine	1,000,000
Codeine	500,000
Dextromethorphan	100,000
Dihydrocodeine	500,000
Heroin	80
Hydrocodone	300,000
Hydromorphone	100,000
Imipramine	200,000
Levorphanol	100,000
Meperidine	800,000
Morphine	100,000
Morphine-3-Glucuronide	600,000
Morphine-6-Glucuronide	600,000
Nalorphine	100,000
Naloxone	300,000
Naltrexone	300,000
Norcodeine	600,000
Normophine	100,000
Oxycodoen	400,000
Oxymorphone	100,000

Ordering information

9R129UL	EMIT^® II Plus 6-Acetylmorphine Assay, large	R1=1000 mL and R2=500 mL
9R039UL	EMIT II Plus 6-Acetylmorphine Assay, small	R1=28 mL and R2=14 mL
9A509UL	EMIT Calibrator/Control Level 0	14 mL
9R529UL	EMIT II Plus 6-AM/Ecstasy Calibrator/Control Level 1	10 mL
9R549UL	EMIT II Plus 6-AM/Ecstasy Calibrator/Control Level 2	10 mL
9R569UL	EMIT II Plus 6-AM/Ecstasy Calibrator/Control Level 3	10 mL
9R589UL	EMIT II Plus 6-AM/Ecstasy Calibrator/Control Level 4	10 mL

Services & Support Education & Training

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^* Analytical sensitivity of 1.1 ng/mL on the Viva-Jr®, Viva-E®, and V-Twin® Drug Testing Systems.

The products/features (mentioned herein) are not commercially available in all countries. Due to regulatory reasons their future availability cannot be guaranteed. Please contact your local Siemens Healthineers organization for further details.