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SPECT/CT Quantification for Theranostics

SPECT/CT Quantification for Theranostics

More power than ever to personalize care

There is clear momentum in medicine for the fast-growing area of theranostics. Combining diagnostics and therapy brings new opportunities for delivering the right treatment at the right time to each patient. But having reliable patient-specific data is essential for achieving this.

When establishing a theranostics practice, differentiating between technologies can be challenging. To better understand why all SPECT/CTs are not created equal, three points quickly rise to the top of the list:

  • medium- and high-energy isotopes imaging capabilities
  • workflow feasibility
  • reliable quantification

Projected market growth

18%


The global nuclear medicine radiopharmaceutical market is expected to grow 18% per year from 2020–2031 to reach a total of $33B in 2031.1

32%


The radiotherapeutics market is expected to grow by 32% per year from 2020–2031.1


75%

In 2031 the radiotherapeutics market is expected to make up 75% of the global nuclear medicine radiopharmaceutical market—meaning it will be ~$25B.1

Benefits

Dependably image medium- and high-energy isotopes

System design is critical for reliably imaging medium- and high-energy isotopes. With sodium iodide crystals, the only SPECT crystal technology clinically proven to manage all SPECT energies, and the flexibility to easily change and use collimators specifically designed for each isotope, our SPECT/CTs provide the technology foundation required for a theranostics program. And with TrueCalc™ high count rate detector technology, there is peace of mind in having consistent quantitative accuracy across the therapy cycle and multiple time points.
A comparison of conventional quantification calibration versus the automated approach CHUV employs.

Easily implement quantification into a workflow

Conventional quantification calibration workflows can take as many as 14 manual, time-intensive steps—increasing the potential for error. xSPECT Quant™ provides an automated calibration solution that is fast, accurate, and easily implemented into your department’s workflow. With xSPECT Quant, you no longer need to rely on a medical physicist to complete the calibration. Calibration can be easily performed by a technologist, thus allowing for more flexibility within the department.

Reliably produce accurate quantitative values

Precise and reproducible to within 5%,2,3 xSPECT Quant provides the degree of standardized SPECT/CT quantification you rely on for theranostics and radionuclide therapy. Using a patented NIST-traceable calibration source, xSPECT Quant is unrivaled in its level of accuracy,4 and is your basis for optimal therapy planning and management. xSPECT Quant is available for multiple isotopes, including 177Lu and 131I.4

Insights

Scientific presentations
177Lu Case highlights
Case studies
Dr. Kuwert, Clinic of Nuclear Medicine, Universitätsklinikum Erlangen, Germany, speaks at the EANM 2019 lunch symposium.

Defining the Clinical Value of Quantitative SPECT/CT

Dr. Kuwert, Clinic of Nuclear Medicine, Universitätsklinikum Erlangen, Germany, speaks at the EANM 2019 lunch symposium.

White paper

Accurate, reproducible and standardized SPECT/CT quantification

Data courtesy of Friedrich Alexander University, Erlangen, Germany.

Accurate, reproducible, and standardized quantification

Written by A. Hans Vija, PhD, Carl von Gall, MD, and Partha Ghosh, MD
Siemens Healthineers Molecular Imaging

1

Goethals, P. and Zimmermann, R., 2021. Clinical Radiopharmaceuticals Report & Directory. NUCLEAR MEDICINE Report & Directory (PART 2) 8th. Edition. [online] MEDraysintell, p.29. Available at: <http://www.medraysintell.com> [Accessed 27 February 2022].

2
Accuracy of Bq/ml quantification measured per NEMA NU1-2018 using a uniform cylinder phantom. Calibration method: NIST-traceable source.
3
For xSPECT 99mTc and xSPECT 177Lu for large uniform objects with volumes larger than 3000 mL.
4
xSPECT Quant 131I is not commercially available in all countries. Due to regulatory reasons, its future availability cannot be guaranteed. Please contact your local Siemens Healthineers organization for further details.
The statements by Siemens Healthineers' customers described herein are based on results that were achieved in the customer’s unique setting. Since there is no “typical” hospital and many variables exist (e.g., hospital size, case mix, level of IT adoption) there can be no guarantee that other customers will achieve the same results.

Header image data courtesy on file.