Scientific and Clinical Publications

Welcome to the Siemens Healthcare Laboratory Diagnostics Scientific and Clinical Publications, a compilation of peer-reviewed journal articles, clinical case studies, scientific posters and more.

To retrieve technical documents and Material Safety Data Sheets (MSDS) for the entire Siemens Healthcare Diagnostics portfolio, including instruments, assays, and test kits, visit our Online Document Library.



May 01, 2016

Automation Upgrade Helps Improve Efficiency and Grow Outpatient Business

North Memorial Health Care Moves to Advanced Automation Solution

April 01, 2016

Are you ready for laboratory transformation?

The influence of diagnostic tests on clinical decisions is very high – almost 75% of clinical decisions are based on a diagnostic test. IVD is witnessing proliferation of technology in terms of new assays, workflow excellence, turnaround time, etc.

Nov 01, 2015

Glucose Correlation between POC RAPIDPoint 500 Blood Gas System and Two Central Laboratory Platforms

Designed for easy use in POC environments, the RAPIDPoint 500 system demonstrated excellent glucose correlation with the laboratory RAPIDLab 1265 and ADVIA 1800 systems.

Nov 01, 2015

Performance evaluation of four 25-hydroxyvitamin D assays to measure 25-hydroxyvitamin D2

Clin Biochem: The bias results obtained for the Siemens ADVIA Centaur assay and Roche ELECSYS assay were slightly lower than those for the DiaSorin LIAISON assay and the Abbott ARCHITECT assay, but all 25(OH)D assays demonstrated acceptable performance.

Nov 01, 2015

Troponin I Testing Improves Cardiac Interventions: Community Hospital of the Monterey Peninsula

Learn more about why the Stratus CS Acute Care System is now the analyzer of choice for all laboratory cardiac troponin I testing at the Community Hospital of the Monterey Peninsula.

Oct 01, 2015

Advanced automation system drives lab efficiency while optimizing use of staff time

Following the trend in the US, pressure is mounting on big European hospital labs to consolidate their operations and boost workflow performances while at the same time making better use of their staff. The Aptio Automation system from Siemens Healthcare Diagnostics goes a long way to fulfill these objectives.

Sep 01, 2015

Advantages of Automatic Quality Control (AQC) for Blood Gas Testing QC

The totality of independent quality checks available with Siemens Healthcare blood gas analyzers, in combination with the Automatic Quality Control system, helps to ensure the integrity of all reported patient test results.

Sep 01, 2015

Facilitating Cardiac Decision Making at the Point of Care

The ED laboratory at Addenbrooke's Hospital is the first in the UK to install two Stratus® CS 200 Acute Care™ Diagnostic Systems*, enabling rapid diagnosis of CVD to quickly determine an appropriate treatment plan.

*Not available for sale in the U.S. Product availability varies by country.

Aug 01, 2015

Allergy: research and diagnostic updates

In vivo and in vitro studies have shown effects of vitamin D on allergy, asthma, and lung function. Clinical trials may help determine recommendations of the optimal dose of vitamin D for prevention and treatment of asthma and allergic disease.

Apr 01, 2015

ADVIA Centaur® XP CHIV, HBsAgII, and HCV assays are highly specific in Norwegian blood-donors

This study illustrates assay performance in a population of 1000 Norwegian blood donors. Testing was performed to determine the serological profile that could be expected in such a population.

Mar 15, 2015

The Value of a Standardized and Certified Vitamin D Total Assay for Clinical Confidence

Endocrine Society: ADVIA Centaur® Vitamin D Total demonstrated comparability to LabCorp's CDC certified LC/MS/MS across the full range of the assay, measuring both forms of 25(OH)vitamin D accurately.

Mar 01, 2015

Getting to the Heart of the Matter: Evolving Troponin Assays for Earlier Diagnosis of AMI

Clinical implications of more sensitive cTn assays: lower Tn levels can be detected earlier, and serial sampling can reflect a change ≤ 3 hours after first presentation. Earlier detection and serial samples mean faster AMI diagnosis, and reduced costs.

Mar 01, 2015

The Value of a Standardized and Certified Vitamin D Total Assay for Clinical Confidence

In comparison to a VDSCP-certified 25(OH)vitamin D LC/MS/MS method, the ADVIA Centaur® Vitamin D Total assay produced comparable results across the full range of the assay and accurately measured both forms of 25(OH) vitamin D in a high-throughput assay.

Feb 01, 2015

Automation and Optimization: The importance of the health check

The period following the implementation of laboratory automation begins a new phase in project management—the health check or optimization phase. There are three main reasons for health checks: internal forces, external forces—and peace of mind.

Feb 01, 2015

Development of a Vitamin D Total Assay with LOCI Technology on the Dimension® EXL™ Integrated System

The Dimension® EXL™ Vitamin D Total assay demonstrates acceptable precision, accuracy, and minimal cross-reactivity to the 3-epimer for total 25(OH)vitamin D measurement on the Dimension EXL system.

Feb 01, 2015

Hospital Clinic de Barcelona Advances Its Hemostasis and Hematology Workflow with Aptio Automation

In Spain, Hospital Clinic de Barcelona has been able to consolidate instruments, integrate and automate STAT testing, reallocate staff to higher-value responsibilities, and save
upwards of €600,000 in tube costs.

Jan 01, 2015

Educating for More Effective Allergy Treatment

Helping Hiroshima University in Japan is the children’s book Mickey and the Giant Kachoo! that Siemens and the Walt Disney Company have created

Dec 17, 2014

Right-Sizing Laboratory Automation Clinical Laboratory Products

Laboratory automation expert and consultant Robin A. Felder, PhD says that most clinical laboratory errors—and more than half of all laboratory costs—are associated with preanalytical and postanalytical processing of specimens.

Dec 01, 2014

Consolidation with Aptio Automation Drives Cost-efficient, Patient-centric Care at NHS Tayside

NHS Tayside in Scotland consolidated four lab disciplines onto a single track. With Aptio Automation, 7000 tubes/day are processed—a 20% increase with no additional staff. Decreased TAT across the board drove a 61% improvement in the TAT for add-on tests.

Dec 01, 2014

Fully Automated: Thousands of Blood Samples every Hour

Siemens is supplying automation technology for the longest and one of the most cutting-edge sample processing lines in any clinical laboratory. The line, or automation track, 200 meters long, in Marlborough, Massachusetts at Quest Diagnostics.

Dec 01, 2014
Method Comparison of Blood Gas Systems: RAPIDPoint® 500 POC Analyzers vs. RAPIDLab® 1265 Analyzers
"Regardless if a test is performed on the Siemens point-of-care analyzer with planar sensors or the central laboratory blood gas analyzer using Ready Sensor® electrodes, comparable results for the same patient sample will be reported."

Dec 01, 2014
VERSANT kPCR Sample Prep Module: Quality Nucleic Acid Extraction from a Wide Variety of Specimens
VERSANT® kPCR SP Module allows the extraction of a batch size of 1 to 96 samples in about 3 hours. Sample types may be mixed in an individual batch run. There are several extraction protocols for different sample input and eluate output volumes.

Nov 01, 2014
Implementation of Point-of-Care Testing in an Ambulatory Practice of an Academic Medical Center
Am J Clin Pathol: A Massachusetts General Hospital/Harvard Medical School study reported decreases in follow-up phone calls and letters of 89% and 85%, respectively, and a 61% decrease in patient revisits following implementation of POCT, which included the DCA Vantage® Analyzer.

Nov 01, 2014

Performance of the ADVIA Centaur® Vitamin D Total Assay Standardized to Reference Measurement

The CDC certification attests to the accuracy of the Siemens ADVIA Centaur® Vitamin D Total assay and its standardization to the RMP specified by the VDSP.

Nov 01, 2014

Siemens BNP assays: Analytical performance and comparison to commercially available BNP assays
Siemens BNP assays demonstrate excellent precision and recovery from lot to lot. Room-temperature and refrigerated sample stability between the Dimension Vista and the TRIAGE BNP assays are similar.

Sep 03, 2014
Complying with the Affordable Care Act
How Floyd Medical Center in rural Georgia, USA, reduced costs while lowering readmission rates by 63% and improving patient satisfaction.

Sep 01, 2014
Performance Evaluation of LOCI® Vitamin B12 and Folate Assays on the Dimension® System
Study results demonstrate good performance of the fully automated vitamin B12 and folate assays on the Dimension® EXL™ with LM Integrated Chemistry System. Accuracy was evaluated by recovery of the WHO Vitamin B12 and Folate International Standard 03/178.

Sep 01, 2014
Performance Evaluation of a Ready-to-use Liquid Triglycerides Assay on the ADVIA Chemistry Systems
An improvement of Triglycerides_2* or TRIG_2, using ready-to-use liquid reagent is under development. Also a new concentrated reagent ( TRIG_c*) was developed which could be automatically diluted on-system to provide larger number of tests per kit.

Sep 01, 2014

Reduction in the number of reported results from blood gas analyzers on an adult ICU by effective…

CPOCT Poster from Amsterdam. Six different preset panels were installed on the blood gas systems and a training program was completed to apply a standardized and effective method of order management and selective usage.

Sep 01, 2014

Siemens Installs World’s Longest Lab Automation Track at Thyrocare in India

At 93.5 meters, the installation of Siemens Aptio Automation Solution is also India’s first. Thyrocare can perform approximately 200,000 tests per day. A total of 24 immunoassay and 7 chemistry systems are part of this automation solution.

Aug 06, 2014
24/7 Service for Young Diabetes Patients
Pediatrician has implemented an innovative concept for treating diabetes in the Netherlands. Its pillars are 24/7 service, cutting-edge lab technology with DCA Vantage® Analyzer, and the Internet as a channel for medical information.

Aug 01, 2014
Current considerations of HIV and HCV testing and risks of vertical transmission during pregnancy
MLO: Without diagnosis and proper treatment, the risk of vertical transmission of HIV is as high as 25%,1 and the odds of vertical HCV transmission are significantly higher for HIV-HCV−coinfected mothers.

Aug 01, 2014
Standardization of the ADVIA Centaur® Vitamin D Total Assay
The study described in this document demonstrates the alignment of the ADVIA Centaur® Vitamin D Total Assay to the 25(OH)vitamin D RMP and its impact on patient results.

Jul 30, 2014

Assessment of harmonization among Siemens point-of-care and central laboratory blood gas systems

AACC poster presented comparison studies performed with whole blood on RAPIDPoint® POC and RAPIDLab® central laboratory blood gas systems, in accordance with CLSI EP-09 guidelines. Harmonization at the clinically relevant decision levels was demonstrated.

Jul 23, 2014

Vitamin D: The More We Know, the Less We Know

Clin Chem: Current assays measure total 25(OH)D, which is made up of the free component and that bound to VDBP. Reference intervals, influence of VDBP, bioavailable Vit D, VDBP polymorphisms, are discussed in this Q & A.

Jul 04, 2014
A Ferrari in the Lab
The Santa Casa Hospital in Porto Alegre, Brazil, is one of South America’s leading hospitals. Lab director Dr. Carlos Franco Voegeli uses innovative technology to increase significantly the lab’s speed, performance, and precision.

Jul 01, 2014
ADVIA Centaur® Vitamin D Total Assay: Expected Vitamin D Values in a Healthy Pediatric Population
The goal of the study was to test healthy pediatric donor specimens to establish pediatric observed values for the ADVIA Centaur® Vitamin D Total assay. Vitamin D levels were consistent across the three age groups, with no apparent changes with age.

Jul 01, 2014
Analytical Sensitivity and Workflow of the VERSANT® Hepatitis C Virus Genotype 2.0 Assay (LiPA)
Automation of the VERSANT® HCV Genotype 2.0 Assay (LiPA) workflow results in higher throughput, improved efficiency and decreased time to results. It is a sensitive and reliable HCV genotyping assay. *RUO in the U.S.

Jul 01, 2014
Determination of Pediatric Reference Intervals for ADVIA® and Dimension® Systems Thyroid Assays
Pediatric reference intervals were established for ADVIA Centaur®, Dimension Vista® and Dimension® EXL™ thyroid assays using pedigreed samples. These data will assist with the interpretation of thyroid measurements in infants, children and adolescents.

Jun 19, 2014

Influence of VDBP on Accuracy of Vitamin D Measurement Using the ADVIA Centaur®

Int J Endocrinol: The ADVIA Centaur® Vitamin D Total assay demonstrates acceptable performance compared with an LC-MS/MS method for populations containing different amounts of DBP.

Jun 18, 2014
Dr. Roy's Discovery
Dr. Sudip Roy from MEDICA Superspecialty Hospital laid the foundation for the successful treatment of diabetic foot ulcers in India. He uncovered the origin of this unusual infection and was able to improve the chances of a cure significantly.

Jun 01, 2014
Advances in Acridinium Ester Technology on ADVIA Centaur® Immunoassay Systems
Robust acridinium ester remains the chemiluminescence immunoassay technology of choice, through its flexibility for use in the realization of improved performance, and in the development of novel immunoassays.

Jun 01, 2014
Laboratory automation
The CentraLink System version for 2015 supports paperless workflow and embraces the multi-disciplined approach by bringing together haematology, chemistry, and IA analytics.

Jun 01, 2014
N Latex FLC serum free light-chain assays in patients with renal impairment.
Clin Chem: Study to establish ranges for N Latex free light-chain (FLC) monoclonal-based nephelometric assays in patients with renal impairment found the N Latex FLC κ/λ ratio in those patients didn't differ from reference limits for healthy controls.

May 28, 2014
Analyzing Tumor DNA in the 21st Century
How to be Twice as Fast in Processing Tissue Samples in Molecular Pathology. Using an automated solution, researchers at Leiden University Medical Center, Netherlands, have succeeded in isolating DNA and RNA from minuscule tissue samples.

May 21, 2014
A Passion for Top Notch Education
Professor at Thailand’s Premier School for Aspiring Physicians: We have had an increase of 10-15 percent in the number of specimens handled, and the laboratory completes the work with a high level of accuracy and reliability.

May 05, 2014

Allergen Component sIgE Measurement With IMMULITETM 2000 System: Accuracy and Intermethod Comparison

JCLA: Accuracy of 3gAllegy molecular allergens compared with the ImmunoCAPTM. A high diagnostic accuracy of the sIgE to allergen components measurement with IMMULITETM 2000 and a high agreement with ImmunoCAP platforms were shown in this study.

May 01, 2014
Aligning the ADVIA Centaur® Vitamin D Total Assay to the Vitamin D Standardization Program
The ADVIA Centaur® Vitamin D Total assay has been re-standardized to align with the Reference Measurement Procedure (RMP) used in the Vitamin D Standardization Program, introduced by the NIH ODS, NIST, CDC, and Ghent University.

May 01, 2014
Diabetes: the past, the present, and the challenging future
MLO: The HbA1c level reflects the integrated glucose value over the preceding 12 weeks. Epidemiological studies have shown that HbA1c values are superior to glucose in estimating the risk of microvascular complications.

Apr 11, 2014

Clinical complexity and the effectiveness of an intervention for depressed diabetes patients

Chronic llness: HbA1c levels in patients with diabetes and depression were monitored using a DCA 2000 Analyzer. Patients were randomized to usual care or telephone cognitive behavioural therapy that emphasized physical activity.

Apr 01, 2014
Assessment of Harmonization among Siemens Point-of-care and Central Laboratory Blood Gas Systems
Harmonization at clinically relevant medical decision levels was demonstrated among Siemens POC and central lab blood gas systems for the measurands evaluated. The slopes for each measurand were between 0.96 and 1.25, with r2 ≥ 0.9785.

Apr 01, 2014
Cardiotoxicity associated with trastuzumab and chemotherapy used for HER2-positive cancers
MLO: Serum HER2/neu levels can be used to monitor metastatic breast cancer patients, and as an aid in monitoring metastatic breast cancer patients treated with chemotherapy, hormonal therapy, radiotherapy, and HER2/neu-targeted therapies.

Apr 01, 2014
Evaluation of the automated coagulation analyzer Sysmex® high throughput laboratories
Clin Chem Lab Med: The Sysmex® CS-5100 Hemostasis System is able to rapidly and precisely measure patient samples. No considerable influence on test comparibility was found for elevated levels of free hemoglobin, bilirubin or triglycerides.

Apr 01, 2014
Reduction of False-Positive Bilirubin Results on CLINITEK Novus® (v1.1) Urine Chemistry Analyzer
The CLINITEK Novus® Automated Urine Chemistry Analyzer* a unique algorithm to decrease false-positive bilirubin results. This serves to decrease the time and costs associated with potentially unnecessary follow-up bilirubin testing.*Not available in U.S.

Apr 01, 2014
San Bortolo Hospital Boosts Productivity with Aptio® Automation and CentraLink™ Data Management
"Laboratory in Vicenza, Italy reduces TAT, streamlines management, and boosts productivity with Aptio® Automation. "

Feb 01, 2014
ADVIA Centaur® Vitamin D Total Assay Accurately Measures Patients on...
This study demonstrates that the ADVIA Centaur® Vitamin D Total Assay traceable to the 25(OH)vitamin D RMP† was shown to be as accurate as LC/MS/MS in assessing  vitamin D levels for patients on vitamin D supplementation.

Feb 01, 2014
Charting New Territory in Laboratory Automation
R&D: Much like adding sections of track to a model train layout, the latest laboratory automation track has the flexibility to curve around obstacles. Remote service improves uptime and efficiency by proactively diagnosing problems

Feb 01, 2014
Forging a Unified Healthcare Culture
Brazil’s DASA has reduced turnaround time and error rates. The need to split samples for analysis dropped from 100 percent to 62 percent after the introduction of the ADVIA LabCell System, and 22 percent of the staff were reallocated to other activities.

Feb 01, 2014
Mastering the Volumes
Mumbai, India’s Thyrocare Technologies processes 100,000 diagnostic tests each night – more than in any other comparable lab.

Feb 01, 2014
The Road Less Travelled
In Manipur, India, at Babina Diagnostics the laboratory’s turnaround times have reduced by 30-35 percent with the introduction of the StreamLAB solution, and errors have been significantly reduced.

Jan 01, 2014
An Overview of Viral Hepatitis
Serology testing is important for identifying potentially chronic infections, which generally are asymptomatic until the late stage. In current treatment algorithms, molecular testing plays a key role in therapy and in assessment of therapy success.

Jan 01, 2014

Glucose correlation between Siemens POC RAPIDPoint® 500 blood gas system and 2 central lab platforms…

AACC poster presented how the RAPIDPoint® 500 system demonstrated good correlation with the RAPIDLab® 1265 System and the ADVIA® 1800 Clinical Chemistry System for the glucose measurement.

Jan 01, 2014

Viral loads coupled with CD4+ T-cell counts help define therapy timing and assess treatment efficacy. Resistance testing guides the provider both in initial choice of therapy and in response to changes in drug resistance profiles.

Jan 01, 2014
Other Microbiology / Parasitology
Some genera of bacteria have emerged, particularly in the hospital setting, that are susceptible to very few antibiotics.Table 1 lists some of the more common bacteria that carry resistance to one or more antibiotics.

Jan 01, 2014

Sandwich Assay for Tacrolimus Using 2 Antitacrolimus Antibodies

In addition to being analytically sensitive, true sandwich assays can achieve higher specificity than competitive assay counterparts, as exemplified by much lower cross-reactivity with the drug metabolites and synthetic analogs described in this report.

Jan 01, 2014
Testing for TORCH organisms can identify fetuses and neonates who are at significant risk. Serologic-based TORCH assays can identify infection and facilitate appropriate care thereby effectively reducing the risk of birth defects and fetal demise.

Dec 19, 2013
Syphilis detection using the Siemens ADVIA Centaur® Syphilis Treponemal Assay
Clinica Chimica Acta: Positive and negative agreement was 100% between the Centaur® and IMMULITE® assays. Overall agreement was 99.92% between either of the Siemens assays and the Biokit assay; positive agreement was 99%, and negative agreement was 100%.

Dec 19, 2013
Video: King of Volumes
Economies of scale enable Mumbai-based Laboratory to be market leader. Our documentary film shows how it works.

Dec 01, 2013

A multicenter evaluation of a new automated method for measurement of aCCP

The aCCP assay on the IMMULITE® 2000 XPi has good performance characteristics and shows good concordance with the Immunoscan RA ELISA test, Immunocap 250 and aCCP test on the Roche Modular systems.

Dec 01, 2013
Development of Coagulation Parameters during Childhood and Puberty
The understanding of physiological age-dependent changes in the coagulation system is crucial to an accurate diagnosis.Learn more about the pediatric reference data for a full panel of 23 coagulation parameters measured with Siemens reagents.

Dec 01, 2013
Evaluation of the N Latex free light chain assay in the diagnosis and monitoring of AL amyloidosis.
Clin Chem: Comparison of a novel assay for FLC quantitation based on monoclonal antibodies (N-Latex, Siemens) to the polyclonal antibody-based assay (Freelite™, The Binding Site, UK) in AL amyloidosis.

Dec 01, 2013

TSH Receptor Autoantibodies in Graves’ Disease: Their Utility in Diagnosis and Treatment Monitoring

The study found that including TSI in hyperthyroidism testing algorithms would reduce net diagnostic costs by up to 43%, reduce net costs of misdiagnosis and treatment of unexplained symptoms by up to 85%, and reduce time to diagnosis by up to 46%.

Dec 01, 2013
Video and Article: Non-stop Traffic in the Hospital Lab
At the Wahl Medical Lab in Lüdenscheid, Germany, automation has contributed to increased employee satisfaction and made a 40 percent increase in the number of customers possible.

Oct 28, 2013
Tissue Preparation and Next-generation Sequencing Workflows for Oncology Testing
TJOP: Molecular pathology is a prerequisite for personalized cancer medicine. A university hospital in the Netherlands does DNA isolation within 4 hours in a standardized way with limited hands on time, where operator-to-operator variation is excluded.

Oct 15, 2013
Determination of kFLC and k index in CSF: valid alternative to assess intrathecal immunoglobulin.
J Neuroimmunol: Study data indicates that nephelometric assay for kFLCs in CSF reliably detect intrathecal immunoglobulin synthesis and discriminate multiple sclerosis patients.

Oct 01, 2013
Elimination of Schistosomiasis Transmission in Zanzibar: Baseline Findings before a Randomized Trial
Urine samples were visually inspected for blood using Hemastix® reagent strips, and for S.haematobium eggs by filtering 10 ml of urine through a polycarbonate filter that was quantitatively examined under a microscope by experienced laboratory technicians.

Sep 24, 2013
Association between FLC levels, and disease progression and mortality in chronic kidney disease.
Toxins: Accumulation of FLCs has been observed in patients with chronic kidney disease. Results indicate that FLC κ and λ levels are elevated in CKD patients and are associated with inflammation, vascular calcification and levels of other uremic toxins.

Sep 01, 2013
ARUP Laboratories Transforms Workflow and Shortens Turnaround Times
ARUP Laboratories Shorten Turnaround Times from 43 to 17 minutes.

Sep 01, 2013
Montdidier Hospital Triples Workload and Expands Menu of Tests with New VersaCell Solution
Montdidier Hospital has transformed its lab to extend testing menus, increase work loads, speed turnaround time, increase efficiency, and improve quality.

Sep 01, 2013
NHS Tayside Realizes Vision through Siemens' Aptio Automation
Aptio Automation revolutionizes adaptability with cross-disciplinary tests along the Aptio track, enabling faster, more-comprehensive results reporting with less human intervention.

Sep 01, 2013
Peking Union MCH Achieves Clinical Excellence through Lab Consolidation and Automation
Peking Union grows testing volume at about 15 to 20 percent per year due to the availability of new analytes as well as increasing demand for preventive care.

Aug 01, 2013
Influence of Vitamin D Binding Protein on Accuracy of the ADVIA Centaur® Vitamin D Total Assay
The study demonstrates the impact of DBP concentration on the accuracy of the ADVIA Centaur® Vitamin D Total Assay at levels found in normal patient populations as well with clinical conditions such as pregnancy or chronic kidney disease was negligible.

Aug 01, 2013
N Latex FLC Kappa and Lambda: Urine Application - Free light chains (FLCs) and the kidney
N Latex FLC lambda shows good reactivity with FLC lambda aggregates of small size as present in urine or in serum of patients with polyclonal increase, while the reactivity of the Freeli te lambda assay is lower with these molecules.

Jul 02, 2013

Vitamin D recommendations: the saga continues

JCEM: Paper considers the Endocrine Society Clinical Practice Guideline (2011) in relation to the IOM reference ranges. Individuals at risk for deficiency should maintain 25(OH)vitamin D levels at >75 nmol/L (30 ng/mL).

Jul 01, 2013
An Efficiency Revolution
NHS Tayside in Dundee, Scotland meets the twin challenges of increasing demand and ever-tighter budgets. As the first hospital in Northern Europe to adopt Aptio Automation, it is already reaping the rewards of being at the cutting edge.

Jul 01, 2013

C3-epimer cross-reactivity of automated 25-hydroxyvitamin D immunoassays

Ned Tijdschr Klin Chem Labgeneesk: C3-epimer of 25OHD3 is a potential confounder in Vit D measurement and sufficiency and should not be included in the total 25(OH)D result. None of the current automated immunoassays showed 3-epi-25(OH)D3 cross-reactivity.

Jul 01, 2013
Multicenter Evaluation of New Free Light Chain Methods
Latex-enhanced mouse monoclonal antibody reagents from Siemens for free Ig light chain type kappa (N Latex FLC kappa) and free Ig light chain type lambda (N Latex FLC lambda) were assayed on BN™ II systems and BN ProSpec® systems using serum samples.

Jun 01, 2013

Evaluation of a new blood gas analysis system: RAPIDPoint® 500

Annales de Biologie Clinique: RAPIDPoint® 500 analyzer was compared to the RAPIDLab® 1265 analyzer for p, pO2, pCO2, sodium, potassium, ionized calcium, lactate, and multiple CO-oximetry parameters. Chloride and glucose were compared to Vista 500 system.

Jun 01, 2013

Reducing analytical variation between point-of- care and laboratory HbA1c testing

J Diabetes: Authors report negative bias in HbA1c with the DCA Vantage® Analyzer compared to Tosoh G8 HPLC. They recommend periodic recalibration of POC analyzers to eliminate unidirectional bias and harmonize results between POC and central lab analyzers.

May 21, 2013

Influence of Vitamin D2 Percentage on Accuracy of 4 Commercial Total 25- Hydroxyvitamin D Assays

Clin Chem: Correctly interpreting total 25-OH-D results and monitoring patient compliance requires that vitamin D status, type of supplementation, and measurement method be considered.

May 15, 2013

Low plasma 25-Hydroxyvitamin D and risk of tobacco-related cancer 

Clin Chem: Individuals (n=9791) followed up for 28 years with DiaSorin Liaison. The conclusion was that lower plasma concentrations of 25(OH)vitamin D are associated with a higher risk of tobacco-related cancer, but not with the risk of other cancers.

May 01, 2013
Multicenter study comparing two methods for serum free light chains.
Ann Clin Biochem: Serum free light chain analysis is now well established in the investigation of monoclonal gammopathies.

May 01, 2013

Vitamin D levels for preventing acute coronary syndrome and mortality:... a non linear association

J Clin Endocrinol: Vitamin D in the 20–36 ng/mL range was associated with the lowest risk for mortality and morbidity. The hazard ratio below and above this range increases significantly.

Apr 01, 2013

A New, High-Throughput Assay for Ferritin, Evaluated on the ADVIA® Chemistry Systems
The ADVIA® Chemistry Ferritin assay on the family of ADVIA® Chemistry systems has good performance and can be used in clinical laboratories for the routine determination of ferritin in serum or plasma across a relatively wide range of concentrations.

Apr 01, 2013
Nucleic acid extraction methods from fixed and paraffin-embedded tissues for cancer diagnostics.
Expert Rev Mol Diagn: This review summarizes workflows, challenges, and extraction methods for DNA and RNA from FFPE tissues for cancer diagnostics. The only fully automated system to extract both DNA and RNA was the Siemens Tissue Preparation System.

Apr 01, 2013
Performance Evaluation of the IMMULITE 2000 Anti-CCP IgG Assay
The performance data indicate that the IMMULITE® 2000 Anti-CCP IgG assay is suitable to use as one parameter in the multicriterion classification of rheumatoid arthritis.

Apr 01, 2013
Sensitivity and Specificity of aCCP IgG, RF, and CRP Assays in Diagnosis of Rheumatoid Arthritis
Overall, the IMMULITE® 2000 Anti-CCP IgG assay performed comparably to the Dimension Vista® RF assay for the diagnosis of rheumatoid arthritis, and in combination, the clinical sensitivity was improved from 79% (anti-CCP) and 83% (RF) to 93%.

Mar 01, 2013
Carlos Haya Hospital gains peak efficiency through Aptio Automation with CentraLink™ Data Management
Spain's Carlos Haya Hospital gains peak efficiency through Aptio Automation with CentraLink, doubling tubes/hour while reducing 12 FTEs.

Mar 01, 2013
DASA utilizes Siemens’ systems to deliver high quality care across diverse Brazilian market
DASA’s test volume is rising 15% annually and is expected to reach 22 million by 2015. Test menus must adapt to changing disease vectors and demographic trends. DASA has implemented the ADVIA® LabCell® Automation Solutions.

Mar 01, 2013
CLINITEST® hCG testing on CLINITEK Status®+ Analyzer achieves clinical performance and sensitivity
The study results endorse the increasing uptake of the CLINITEST® hCG test as a replacement for traditional ‘dip and read’ pregnancy test methods.

Mar 01, 2013
DASA utilizes Siemens’ systems to deliver high quality care across diverse Brazilian market
DASA uses multiple high-throughput systems such as the ADVIA 1800 and 2400 Clinical Chemistry Systems for drugs-of-abuse testing, therapeutic drug monitoring, and for new assays.

Mar 01, 2013
Diagnosis of Cow's Milk Allergy: Are low levels of specific IgE significant?
A suggestive clinical history and low levels of IgE (<0.35 kU/L) for milk and casein allergen should be considered of clinical importance. 3gAllergy™ assay sensitivities were higher than the ImmunoCAP® assay, maintaining specificities of ≥ 85%.

Mar 01, 2013

Evaluation of DCA Vantage for rapid HbA1c measurement of capillary blood in young type 1 diabetics

Revue médicale de Bruxelles: HbA1c on DCA Vantage® Analyzer was evaluated against HPLC (Menarini Diagnostics HA8160 analyzer). The mean underestimation of the DCA Vantage was -0.40%: it met the acceptance criteria of a coefficient of variation <3%.

Mar 01, 2013
Syva EMIT II Plus 6-Acetylmorphine Assay: Analytical Performance and Comparison Studies
6-AM is found only in response to heroin intake: it does not arise from intake and subsequent metabolism of either codeine or morphine. To minimize risk of a false result, use a 6-AM assay that has little to no cross-reactivity to morphine, codeine…

Feb 15, 2013
Troponin: Quality and Productivity in Near-Patient Testing
High-quality results in near-patient testing that correlate to the central lab are especially important in cardiac biomarkers used to help diagnose acute coronary syndrome (ACS) or acute myocardial infarction (AMI) in patients presenting to the ED.

Feb 01, 2013
Assessment of a fully automated high-throughput DNA extraction method from FFPE tissue for KRAS…
Exp and Mol Path: DNA was extracted from approximately 150 routine FFPE tissue cores or micro-dissected tissue. With TPS, less than 50% of starting tissue was sufficient as input for micro-dissection. TAT decreased, and 50% less hands-on time was needed.

Feb 01, 2013
Rapid testing for CVDs: troponin
MLO:The development of more sensitive and specific serological biomarkers allows detection of ever-smaller amounts of myocardial necrosis. Troponin assays are improving the diagnostic accuracy and rapid detection of myocardial infarction.

Jan 01, 2013
Anti-phospholipid Syndrome and Testing for Lupus Anticoagulants
The diagnosis of APS is based on the combined presence of typical clinical manifestations, e.g. a vascular thrombotic event or complications during pregnancy, as well as the presence of antibodies directed against phospholipid-binding proteins.

Jan 01, 2013

Diagnosing diabetes mellitus: Performance of HbA1c POC instruments in general practice offices

Clin Chem: This study evaluated 13 HbA1c quality assurance surveys, from POC instruments used in practice offices and instruments in hospital labs to diagnose diabetes mellitus. Some instruments demonstrate analytical quality comparable to lab instruments.

Dec 01, 2012
Functional Sensitivity of Seven Automated Thyroid Stimulating Hormone Immunoassays
All assays showed excellent performance in FS consistent with a “third” generation claim except for the Access 2 system. Further harmonization of TSH immunoassays is required, especially at lower concentrations.

Nov 06, 2012
RNA-based determination of ESR1 and HER2 expression and response to neoadjuvant chemotherapy.
Ann Oncol: TPS was used to extract RNA from individual FFPE tissue sections in 1093 FFPE breast cancer core biopsies. “96.1% of those samples contained sufficient RNA and were included in the study” and were used for RNA expression analysis…

Nov 01, 2012

Diagnostic accuracy of the urinary albumin: creatinine ratio determined by CLINITEK® Microalbumin…

Clin Chim Acta: This study evaluated the ability to rule in or rule out albuminuria in patients attending a renal outpatient clinic. Both the CLINITEK® and DCA 2000+ systems could be used to rule out increased urinary albumin excretion.

Nov 01, 2012
Evaluation of the Stratus CS fluorometer for the determination of plasma myoglobin
Acta Clin Belg: The analytical performance of the myoglobin assay on the Stratus® CS analyzer was evaluated using a Cobas Integra 400 for comparison.

Nov 01, 2012
The Genetics Behind Chronic Inflammatory Bowel Disease
Chronic inflammatory bowel disease poses a diagnostic and therapeutic challenge. Researchers in Kiel, Germany, believe that learning more about the genetic basis through next-generation sequencing might lead to more specific approaches.

Nov 01, 2012
Performance of Dimension Vista Oncology Panel and Comparison to Commercially Available Assays
The Dimension Vista LOCI® oncology assays have excellent precision, minimal interference from endogenous substances, are unaffected by hook up to very high analyte concentrations, and have wide analytical measurement ranges.

Nov 01, 2012
Thyroid Health in Pregnancy: Is it Time to Implement Universal TSH Screening?
As many as 5% of pregnant women experience some sort of thyroid dysfunction, putting themselves and their babies at risk for short-and long term health complications. Potentially serious thyroid imbalances often are underappreciated and may go undetected.

Nov 01, 2012
Video: Decoding Genetic Risk Markers
Next-generation sequencing in patients with chronic inflammatory bowel disease.

Oct 01, 2012

Comparison of HbA1c measurements of samples with elevated fetal hemoglobin by 3 commercial assays

Clin Chim Acta: The American Diabetes Association recommends including % HbA1c ≥6.5% as one of the criteria for diabetes diagnosis. Given stricter requirements for clinical labs measuring HbA1c, factors interfering with HbA1c results “must be recognized.”

Sep 01, 2012
More Knowledge, More Testing
Like many hospital laboratories, the core laboratory at the MetroHealth Medical Center in Cleveland, Ohio, U.S., has to cope with a sharp increase in requests for vitamin D testing without compromising accuracy or efficiency.

Sep 01, 2012

Reference and interpretive ranges for α(1)-antitrypsin by phenotype in adult and pediatric

Am J Clin Pathol: Decreased concentrations of A1AT correlated with heterozygosity and homozygosity for the S and Z alleles in both the adult and pediatric groups. Other rare alleles, such as I, were also associated with decreased concentrations of A1AT.


Aug 11, 2012

Multicenter comparison study of current methods to measure 25-hydroxyvitamin D in serum

Steroids: Significant bias exists between ID–LC–MS/MS and many, but not all, other 25(OH)D assays. Our results indicate the need towards further standardizing assays for 25(OH)D measurement.

Aug 01, 2012
Achieving Quality Care, Cost-Efficiency, and Staff Satisfaction at Swedish Covenant Hospital
Combination of four features with CentraLink™ Data Management System — customizable review ranges, delta checking, QC, and instrument flagging—makes autoverification more powerful, and makes sure results pass all of the established criteria.

Aug 01, 2012

Assessing Total Vitamin D Assays: A French Population Study

The ADVIA Centaur® Vitamin D Total assay has been designed to address the key issues in vitamin D testing. This automated assay has a turnaround time of 18 minutes and throughput of 240 tests per hour to meet high-volume testing needs.

Aug 01, 2012

Improved equations estimating GFR in children with CKD using an immunonephelometric cystatin C

Kidney Int.: The reciprocal of immunonephelometric cystatin C was as well correlated with iGFR as was height/serum creatinine (both 0.88). We developed a new GFR estimating equation and applied it to the remaining 1/3 as a validation data set.

Jul 25, 2012

Measurement of hymenoptera venom sIgE by 3gAllergy™ in subjects with neg. or pos. ImmunoCAP® result

Asia Pacific Allergy: Overall sensitivity, specificity and agreement with systemic reaction were greater for IMMULITE® than for ImmunoCAP. The IMMULITE performed well for detecting sIgE to hymenoptera venom.

Jul 18, 2012

A method comparison of critical blood analytes on Siemens blood gas systems

AACC poster of method comparison showed results on the RAPIDLab® 348 analyzer demonstrated good correlation with those of the RAPIDLab® 1265 and RAPIDPoint® 405 analyzers for the critical analytes (p, pCO2, pO2, sodium, potassium, ionized calcium) tested.

Jul 11, 2012

Long term vitamin D3 supplementation is more effective than vitamin D2...over the winter months

BR J NUTR: Public health recommendations do not distinguish between vitamin D2 and vitamin D3, yet disagreement exists on whether these two forms should be considered equivalent. Daily supplementation of vitamin D3 was more effective than D2.

Jul 05, 2012

Estimating glomerular filtration rate from serum creatinine and cystatin C

N Engl J Med: The combined creatinine–cystatin C equation performed better than equations based on either of these markers alone and may be useful as a confirmatory test for chronic kidney disease

Jul 04, 2012

Evaluation of the N Latex FLC free light chain assay on the Siemens BN analyzer: precision...

Ann Clin Biochem: The analytical performance of N Latex FLC assays is compared to Freelite™ assays. The N Latex FLC assay has good precision, did not exhibit gross antigen excess and can be used in clinical practice based on the analytical performance.

Jul 01, 2012
Antibody Selection Criteria for Cardiac Troponin | Assays
ADVIA Centaur® TnI-Ultra assay meets and exceeds ESC/ACC recommendations. New antibodies and reagent architecture enhance stability and recovery, reduce bias between serum and plasma, lower minimum levels of cTnI detection, and maximize assay precision.

Jul 01, 2012
A True Assessment of Total Vitamin D: Measuring Both 25(OH) Vitamin D2 and D3
A vitamin D assay that fully measures total 25(OH) vitamin D, is standardized, and has acceptable precision will allow the clinical lab to distinguish between patients who have deficiency, insufficiency, and sufficiency.

Jul 01, 2012

Risk factors for nephropathy in diabetic subjects in the South Pacific: Baseline data…

NDT Plus: A DCA 2000 Analyzer measured HbA1c and ACR in study subjects. A high prevalence of incipient and established diabetic nephropathy in these populations highlight “the importance of continued screening for nephropathy and therapeutic intervention.”

Jun 14, 2012

Early loss of the glucagon response to hypoglycemia in adolescents with type 1 diabetes

Diabetes Care: A DCA 2000 Analyzer was used to measure HbA1c levels in study subjects. The glucagon response to hypoglycemia in adolescents with type 1 diabetes is influenced by the duration of diabetes and can be lost early in the course of the disease.

Jun 01, 2012

Analytical performance evaluation of four cartridge-type blood gas analyzers

Clin Chem Lab Med: Parameters were pO2, pCO2, p, potassium, ionized calcium, glucose, lactate, and total hemoglobin. The precision of RAPIDPoint® 405 and ABL90 FLEX analyzers was “remarkably better” than the preset criteria based on ABL700 performance.

Jun 01, 2012

Critical assessment of the clinical/technical workflow involved in the use of cartridge-based POC…

Point of Care: On replacement of blood gas system cartridges, variations exist between manufacturers before systems are operational. QC and maintenance procedures are manufacturer dependent and add time to cartridge installation or daily procedures.

Jun 01, 2012

Impaired exercise tolerance is associated with increased urine albumin excretion in early stages…

Eur J Cardiovasc Prev Rehabil: ACR testing was performed on a DCA 2000 Analyzer. Increased ACR was associated with diminished exercise capacity in the early stages of essential hypertension independently from adverse cardiac adaptations.

Jun 01, 2012
Shining Light on Vitamin D Testing
Labs can meet the demands of increasing Vit D test volumes with an assay on a routine analyzer that detects equimolar 25 (OH) vitamin D2and 25 (OH) vitamin D3 to provide accurate clinical assessment of deficiency, sufficiency, and toxicity.

Jun 01, 2012
Syphilis: Evolving screening algorithms and the role of automated immunoassays
MLO: Current treponemal and nontreponemal assays enable laboratories to produce results rapidly in both low- and high-throughput environments. Clear guidance now enables labs to discriminate presumed positives when using a reverse screening approach.

Jun 01, 2012
System for automated nucleic acid extraction from FFPE sections for routine KRAS mutation testing.
Diag Mol Path: Automated extraction of both DNA and RNA was successful in 339 of 340 FFPE samples representing 5 different tissue types [breast, colon, lymph node, liver, and lung]. TPS was nearly twice as fast as manual method.

Jun 01, 2012

Whole-blood TF-PCA is elevated in type 1 diabetes: Effects of hyperglycemia and hyperinsulinemia

Diabetes Care: A DCA 2000 Analyzer measured HbA1c levels. Patients with type 1 diabetes have elevated circulating tissue factor procoagulant activity (TF-PCA), and are in a procoagulant state that may predispose them to acute cardiovascular events.

May 30, 2012

Empirically derived patterns of perceived stress among youth with type 1 diabetes…

J Pediatr Psychol: The study of perceived diabetes-related stress among youth with type 1 diabetes found that a global measure of stress may not accurately account for the association between perceived stress and metabolic control.

May 01, 2012
Add Consistency to Monoclonal Gammopathy Testing: N Latex FLC kappa and lambda Assays
There are a substantial number of monoclonal gammopathies in which no increased expression of intact immunoglobulin molecules is seen, but rather increased levels of either the FLC's kappa or lambda, resulting in abnormally low or high FLC κ/λ ratio.

May 01, 2012
Assessment of Whole Blood Lactate on the Siemens RAPIDPoint 500 Blood Gas Analyzer
Recognizing sepsis early reduces mortality and morbidity. Lactate testing in critical care settings has become increasingly important. The RAPIDPoint 500 system provides a stable lactate sensor, with a 28-day use life, in a maintenance-free cartridge.

May 01, 2012
Comparison of Siemens IMMULITE® 2000 Anti-CCP IgG Assay with Axis-Shield DIASTAT™ Anti-CCP Assay
The IMMULITE® 2000 assay exhibited performance characteristics consistent with those of commercially available assays for the detection of anti-CCP IgG antibodies in clinically significant populations.

May 01, 2012
From Hours to Minutes
Speed and simplicity are not often words associated with immunosuppressant drug testing for transplant patients. But at Bristol Royal Infirmary in the UK, the Viva-E® System streamlines the process, resulting in improved workflows and better outcomes.

May 01, 2012

Understanding the Challenges of Vitamin D Harmonization

Experts from France, Germany, Italy, U.S. and UK address questions about the impact of LC-MS/MS on present and future of vitamin D harmonization, how laboratories can feel confident in their results, and if assay- or country-specific cutoffs are needed.

May 01, 2012
Understanding the Technical Challenges of Measuring Vitamin D
An assay utilizing monoclonal antibodies will most likely have better lot-to-lot consistency as the monoclonal antibodies are not subject to the variations seen with polyclonal antibodies.

Apr 11, 2012

Effect of acute exercise on glycogen synthase in muscle from obese and diabetic subjects

Am J Physiol Endocrinol Metab: HbA1c levels in study subjects were measured using a DCA 2000 Analyzer. The study found that the molecular regulatory process by whichexercise promotes glycogen synthesis in muscle is preserved in insulin-resistant subjects.

Apr 05, 2012

HbA1c and fasting glucose levels as predictors of retinopathy at 10 years: The French DESIR Study

Arch Ophthalmol: This study evaluated the predictive values of HbA1c and fasting plasma glucose (FPG) for retinopathy 10 years after the baseline examination. HbA1c levels in study subjects were measured by HPLC and with a DCA 2000 Analyzer.

Apr 01, 2012

Achievement of target A1c levels with negligible hypoglycemia and low glucose variability in youth…

Diabetes Care: In youth with short-term T1D who retain residual β-cell function, there is negligible exposure to hypoglycemia and lower glucose variability than in youth with wellcontrolled T1D of longer duration. DCA Analyzers measured HbA1c levels.

Apr 01, 2012

Behavioral intervention for families of youth with type 1 diabetes: Randomized Clinical Trial

Pediatrics: Diabetes management outcomes of a clinic-integrated intervention for families of youth with type 1 diabetes. Change in glycemic control was assessed using outcomes of HbA1c level, measured using a DCA 2000 Analyzer and a central lab method.

Apr 01, 2012
DCA Vantage Analyzer: Metabolic Disease Associates, Erie, PA
The physician assistant and the physician have the HbA1c results ready when the patient is in the room. The immediacy of providing feedback while the patient is still in the office is a significant advantage.

Apr 01, 2012

Effect of a high monounsaturated fatty acid diet alone or with combined vitamin E and C…in type 2

Br J Diabetes Vasc Dis: Total antioxidant status increased following a high-MUFA diet and with vitamin and lycopene. A high-MUFA diet with vitamin E and C, or lycopene improves antioxidant status in type 2 diabetes. A DCA 2000 Analyzer measured HbA1c.

Apr 01, 2012

Infant and toddler type 1 diabetes: Complications after 20 years’ duration

Diabetes Care: Patients’ lifetime HbA1c levels (DCA 2000 Analyzer, Bio-Rad column method, and HPLC) were evaluated. If duration of diabetes is very long, patients seem to be protected against diabetic retinopathy. Protection disappears if control “is bad."

Apr 01, 2012

Physical activity in youth with well-controlled versus poorly controlled type 2 diabetes

Clin Ped: HbA1c levels (determined using a DCA 2000 analyzer) and physical activity were assessed. Youth with well-controlled type 2 diabetes engaged in slightly less moderate to vigorous physical activity than those whose diabetes was not in control.

Apr 01, 2012

Standardization of measurements of 25-hydroxyvitamin D3 and D2 

Scand J Clin Lab Invest Suppl:Drs. Thienpont and Stepman (Ghent University) and Vesper (CDC) on the need for the Vitamin D Standardization Program (VDSP) and the agencies involved in the reference method procedure (RMP), including NIH, CDC, and NIST.

Apr 01, 2012

The alteration of Aspart insulin pharmacodynamics when mixed with Detemir insulin

Diabetes Care: The randomized study found that mixing Aspart with Detemir insulin markedly lowers early action of Aspart and prolongs its time-action profile as compared with the separate injection of these analogs. A DCA Vantage Analyzer measured HbA1c.

Apr 01, 2012

Use of the Mastery of Stress Instrument in caregivers of children diagnosed with type 1 diabetes

The Diabetes Educator: This study was to determine if the Mastery of Stress Instrument (MSI) can assess further education needs of primary caregivers of children newly diagnosed with type 1 diabetes.

Apr 01, 2012

Vitamin D status as an international issue: national surveys and the problem of standardization 

Scand J Clin Lab Invest Suppl: NIH Office of Dietary Supplements (ODS) in collaboration with CDC National Center for Environmental Health (NCEH), NIST and Ghent University established the Vitamin D Standardization Program (VDSP) in November 2010.

Apr 01, 2012
What if your ED cardiac-testing program could help decrease inpatient mortality by 2.3%?
A Premier Research Services study found that utilization of the Stratus® CS Cardiac Analyzer in the ED can lead to reduced inpatient mortality rates, length of stay, and overall cost of care.

Mar 23, 2012
Comparison: RNA-based EndoPredict multigene test between core biopsies and corresponding surgical…
J Clin Path: RNA was extracted from 40 FFPE tumor sections and 40 corresponding core biopsies using TPS. Eluates were analyzed for RNA expression analysis with real-time, one-step RT-PCR.

Mar 22, 2012

Evaluation of urine albumin, creatinine, and ACR assay on 2 POCT analyzers relative to central lab

Clin Chim Acta: Spot urine samples previously analyzed in a central laboratory were run on DCA Vantage and Axis-Shield Afinion analyzers. Both showed good correlation to the central lab tests. Afinion analyzers have to use a different normal range for ACR.

Mar 20, 2012

Emotional processing and self-control in adolescents with type 1 diabetes

J Pediatr Psychol: Emotional processing interacted with self-control to predict HbA1c levels, such that when adolescents with type 1 diabetes had both low emotional processing and low self-control, “HbA1c was poorest.”

Mar 06, 2012

Increased urinary excretion of angiotensinogen is associated with risk of chronic kidney disease

Nephrol Dial Transplant: Urinary concentrations of albumin and creatinine were measured using a DCA 2000 Analyzer. Urinary angiotensinogen may be a useful clinical biomarker for the identification of patients at a high risk for CKD.

Mar 01, 2012
Cardiac troponin I measurement: Confluence of clinical need and assay performance
This article will focus on performance of the cardiac troponin I (cTnI) assay available on Dimension Vista® Intelligent Lab System and how this system meets established needs for these critical patient measurements.

Mar 01, 2012

Comparison of four current 25-hydroxyvitamin D assays

Clin Biochem: The performance of vitamin D total assays (ADVIA Centaur and Elecsys) was compared to that of LC-MS/MS and LIASON 25-OH Vitamin D total assays. The new, automated total vitamin D assays show acceptable correlation with LC-MS/MS.

Mar 01, 2012
The ADVIA Centaur® Enhanced Estradiol Assay: Performance and Standardization
Studies highlight the improved precision, sensitivity (LoB, LoD, FS), and dynamic range of this new assay, and demonstrate its improved standardization to ID-GC/MS over earlier assays and another commercial ID-GC/MS–standardized assay.

Mar 01, 2012
Elimination of HbS and HbC Variant Interference in the HbA1c on the ADVIA® Chemistry Systems
The improved ADVIA® Chemistry Hemoglobin A1c method (A1c) accurately assays samples with the hemoglobin variants HbC or HbS and demonstrates good agreement with the NGSP reference method.

Mar 01, 2012

Laboratory Automation: Important Considerations

At Laboratorio Dr. Joaquim Chaves in Portugal, overall lab costs were reduced by 30%. And, with the new system in place, the lab generates 30 tons less material waste each year. In fact, solid-waste volume was cut by 61% and liquid waste by 74%.

Mar 01, 2012
Patient care and accreditation with the RAPIDComm 4.0 Data Management System
At London’s 900 bed Royal Free Hampstead National Health Service (NHS) Trust, RAPIDComm 4.0 provides connectivity to blood gas, urine chemistry, and diabetes care analyzers. Provide POC coordinators with real-time oversight from a single location.

Feb 01, 2012

Serum 1,5-anhydroglucitol concentrations are a reliable Index of glycemic control in type 2…

Diabetes Care: Urinary albumin and creatinine levels were determined with a DCA 2000 Analyzer. 1,5-AG levels do not appear to be influenced by mild or moderate renal dysfunction, suggesting it is a reliable glycemic marker in type 2 with CKD stages 1–3.

Feb 01, 2012

Prevalence of and risk factors for diabetic retinopathy in Koreans with type II diabetes…

Br J Ophthalmol: Study subjects underwent laboratory examinations including ACR testing using the DCA 2000 Analyzer. In addition to traditional risk factors, insulin resistance was associated with an increased risk of DR in Koreans with type 2 diabetes.

Feb 01, 2012
The Best of Both Worlds
St. Mary’s Medical Center in Evansville, Indiana, U.S., chose the Siemens ADVIA Centaur® XP Immunoassay System for its reliability, accuracy, and ease of use in HIV and hepatitis testing.

Feb 01, 2012

The diagnostic power of direct CDT immunoassay in alcoholics. Absolute or relative values?

Alcohol: The diagnostic sensitivity, specificity, negative and positive predictive value, and also the positive and negative likelihood ratios do not differ between results expressed in relative or absolute units independently of cutoff chosen.

Jan 01, 2012

A systematic review: influence of Vit D supplementation on serum 25(OH)Vit D concentration

JCEM:76 trials - Vit D2 supplementation was associated with lower serum increases in total Vit D than Vit D3. Calcium supplements and high 25(OH)Vit D levels at baseline were non-significantly associated with lower increases in 25(OH)Vit D concentrations.

Jan 01, 2012

Association of IGF1 with glycemic control and occurrence of severe hypoglycemia in type 1 patients

Endocrine Connections: HbA1c levels in outpatients were measured using a DCA 2000 Analyzer. Results suggest that in type 1 diabetes, circulating IGF1 levels are negatively associated with glycemic control.

Jan 01, 2012

Diagnostic pathways for exclusion and diagnosis of kidney diseases

Clin Lab: In 2006, a CCLM working group developed diagnostic pathways for the detection and differentiation of renal diseases. The present paper describes pathways regarding GFR, hematuria, leukocyturia and proteinuria.

Jan 01, 2012

Divergence factor between HbA1c measurement DCA Vantage and the domestic daily method used in Japan

Journal of the Japan Diabetes Society: The authors investigated the divergence between HbA1c measurement using the DCA 2000/Vantage analyzer and the daily method used in Japan referencing the KO 500 method.

Jan 01, 2012
Gene expression classifier predicts for hypoxic modification of radiotherapy with nimorazole...
Radiotherapy and Oncology: TPS was used to extract RNA from 323 individual head/neck squamous cell carcinoma (HNSCC) FFPE tissue samples that had been stored for up to 25 years. Extracted RNA was used with real-time, two-step RT-PCR.

Jan 01, 2012

In vitro performance of a new non-invasive extracorporeal saturation monitor

Anaesthesia: A simulated bypass circuit compared accuracy and precision of a non-invasive oxygen saturation monitor against the Siemens RAPIDLab® blood gas system. M3 monitor performance compared favorably “with the gold standard of the RAPIDLab® analyzer.”

Jan 01, 2012

The effect of perchlorate medication on point-of-care testing

Clinical Laboratory: A patient presented with carbimazol-induced toxic epidermal necrolysis. After replacement of carbimazol by sodium perchlorate, a “huge discrepancy” in ionized calcium by two POCT systems was observed.

Dec 09, 2011

Sensitization to cereals and peanut evidenced by SPT and sIgE in food tolerant grass pollen allergic

Clin Transl Allergy: False-positive cereal or peanut allergy diagnoses happen in grass pollen allergic subjects with no history or clinical reactions to foods botanically related to grass. CCDs and allergen components can cause measured IgE-sensitizations.

Dec 01, 2011
New Anticoagulant Testing
Studies have assessed the ex vivo and in vitro dose-dependent effect of the new anticoagulants in healthy individuals and patients. This white paper summarizes the pharmacology of the new anticoagulants and describes their influence on coagulation tests.

Nov 09, 2011

Vitamin D deficiency in obese children and Its relationship to glucose homeostasis

J Clin Endocrinol Metab: A DCA Vantage Analyzer was used to determine HbA1c levels in study subjects. Lower 25(OH)D level “is associated with risk factors for type 2 diabetes in obese children.”

Nov 01, 2011

Continued reduction in the prevalence of retinopathy in adolescents With type 1 diabetes…

Diabetes Care: Clinical data was collected between 1990 and 2009. A DCA 2000 Analyzer is cited in the abstract. Decline in retinopathy, borderline elevation of ACR, and microalbuminuria supports guidelines of lower glycemic targets and use of MDI/CSII.

Nov 01, 2011

Fast separation of 25-(OH) Vit D3 from 3-epi-25-(OH) Vit D3 by LC-MS/MS: variable prevalence…

Clin Chem: Limitation of most LC/MS/MS methods is interference from co-eluting isomeric compounds having identical elemental composition but different structure, leading to Vit D overestimation.

Nov 01, 2011

Media habits, physical activity, socioeconomic status, and glycemic control in youths with type 1

Diabetes Care: HbA1c levels in study subjects were determined using a DCA 2000 Analyzer. Diabetes duration, socioeconomic status, and daily media consumption time were significant risk factors for glycemic control in youths with type 1 diabetes.

Nov 01, 2011
The Lab of the Future – Today
G. Fornaroli Hospital in Magenta was one of the first hospitals in Italy to install the VersaCell® solution. It streamlines workflow and reduces risks from human error, all while saving time, space, and money.

Oct 01, 2011

Adoption of the ADVIA Centaur® Vitamin D Total Assay by the ULB–Institut de Biologie Clinique…

The ADVIA Centaur® Vitamin D Total assay showed good precision, with total CVs of 8.30% (mean: 21.90 ng/mL) and 5.5% (mean, 89.79 ng/mL).

Oct 01, 2011

African Americans’ perception of risk for diabetes complications

Diabetes Educator: This study explored perceived risk for complications among African-American adults with type 2. A DCA 2000+ Analyzer measured HbA1c. Risk perception was not in line with risk, as indicated by physiologic measures.

Oct 01, 2011
Clinical multicenter evaluation of a new FXa-based antithrombin assay.
Int J Lab Hematol: The INNOVANCE® Antithrombin assay has high sensitivity for Antithrombin deficiencies and is reliable, precise and suitable for routine clinical use.

Oct 01, 2011

Does Blood Glucose Monitoring increase prior to clinic visits in children with type 1 diabetes

Diabetes Care: A DCA Vantage Analyzer was used to determine HbA1c levels in study subjects. Evidence of a white coat adherence effect, with BGM frequency increasing before a clinic visit, was found only among children with low HbA1c levels.

Oct 01, 2011

Limited overlap between intermediate hyperglycemia as defined by A1c 5.7–6.4%, IFG, and IGT

Diabetes Care: HbA1c levels were measured using a DCA 2000 Analyzer. Prevalence of isolated IH was high, with limited overlap between the definitions. An A1c of 5.7–6.4% detects, in part, different individuals with IH compared with IFG and IGT.

Oct 01, 2011
Monitoring Metastatic Breast Cancer with Serum HER-2/neu: Individual Patient Profiles
The individual patient profiles presented in the paper demonstrated that serum HER-2/neu levels reflected the clinical course of disease in patients with metastatic breast cancer whose baseline levels were greater than 15 ng/mL.

Oct 01, 2011

Neurocognitive outcomes in young adults with early-onset type 1: A prospective follow-up study

Diabetes Care: The study found no difference in general intellectual ability, memory, and emotional difficulties in subjects with early-onset type 1 diabetes compared with controls, and no deterioration over time. A DCA 2000 Analyzer measured HbA1c.

Sep 01, 2011

Cluster-randomized trial of a mobile phone personalized behavioral intervention for glucose control

Diabetes Care: The primary outcome was change in glycated hemoglobin levels (as measured using a DCA 2000 Analyzer) over a 1-year treatment period. Behavioral mobile coaching “substantially reduced glycated hemoglobin levels over 1 year.”

Sep 01, 2011

Complexed PSA: A First-Line Aid in Prostate Cancer Detection and Management
The cPSA test offers the advantage of higher specificity for the detection of prostate cancer than total PSA, making cPSA a preferred first-line test. Using cPSA has resulted in a reduction in the number of unnecessary biopsies by as much as 20 percent.

Sep 01, 2011
Confronting the AIDS Epidemic: New Guidelines and Programs Offer Hope for Reduction of the Global HIV Burden
Sensitive testing technologies are central to this move toward more widespread screening, providing tools for early detection that support both optimal patient management and infection control.

Sep 01, 2011
Detection of Hepatitis B Virus Surface Antigen (HBsAg) Mutants by IMMULITE® 2000 HBsAg Assay
"The IMMULITE® 2000 HBsAg Assay is able to detect HBsAg mutants that escape detection by some commercial immunoassays and is therefore a robust assay for the diagnosis of HBV infection."

Sep 01, 2011
Development of a New Sex-Hormone Binding Globulin (sHBG) Assay on the ADVIA Centaur® System
The ADVIA Centaur® SHBG Assay accurately measures SHBG level across the reportable range of the assay. The assay demonstrated repeatability in precision, accurate dilution recovery, and acceptable correlation with another commercially available method.

Sep 01, 2011
Evaluation of a New Dehydroepiandrosterone Sulfate Assay on the ADVIA Centaur® System
The Siemens ADVIA Centaur® DHEAS Assay is a rapid competitive immunoassay that is sensitive and precise. The assay provides reliable results across a wide range of clinically relevant concentrations.

Sep 01, 2011

Evaluation of lactate measurement on the Siemens RAPIDPoint® blood gas system

Point of Care: Marked improvements in sensor use life were achieved by controlling diffusional losses of the lactate oxidase enzyme and by adjustments to reagent formulation.

Sep 01, 2011
Gain efficiency with advanced blood gas connectivity
A 500 bed NHS hospital uses RAPIDLab® blood gas analyzers linked by RAPIDComm® to reduce manual maintenance. The software monitors that all is well and undertakes problem-solving processes if required.

Sep 01, 2011
Living with Metastatic Breast Cancer
Siemens innovative Serum HER-2/neu test is the only Serum HER-2/neu test that can indicate whether metastatic breast cancer is progressing or responding to treatment.

Sep 01, 2011
Neonatal Total Bilirubin Method Evaluation: Whole Blood on the RAPIDLab® 1200 System versus Plasma…
The nBili parameter on RAPIDLab® 1200 Blood Gas System Models 1245 and 1265 is comparable to that of the VITROS 950 plasma chemistry method. Using direct spectrophotometry, RAPIDLab® provides results in only 60 seconds on whole blood neonatal specimens.

Sep 01, 2011
A new molecular predictor of distant recurrence in ER-positive, HER2-negative breast cancer adds...
Clin Cancer Res: TPS was used to extract RNA from 1702 individual 5 or 10 µm whole FFPE breast cancer tissue sections that had been stored for up to 20 years. 98% of eluates were used successfully for real-time, one-step RT-PCR.

Sep 01, 2011
Performance Evaluation of an Improved Anti-Streptolysin O Method (ASO_2) on ADVIA Chemistry Systems
The improved ASO_2 method, when used on any ADVIA® Clinical Chemistry System, can measure serum or plasma ASO concentrations precisely and accurately over a broad range for routine clinical chemistry laboratory use.

Sep 01, 2011
Performance of an Improved Automated Assay for Unconjugated Estriol on the IMMULITE® 2000 Analyzer
Method comparison to GC-MS yielded the following weighted Deming regression characteristics: slope = 0.98, intercept = 0.02 ng/mL, and r = 0.97. The reportable range was 0.07–12 ng/mL.

Sep 01, 2011
Progesterone: Physiology and Clinical Utility
"Progesterone is useful for evaluating the corpus luteum and the placenta; for determining if ovulation has occurred; and for diagnosis of luteal phase deficiency. Progesterone measurements can identify patients at risk for ectopic pregnancy."

Sep 01, 2011
Rush Hour: The race against time to diagnose ACS at St. David‘s South Austin Hospital
Thee hospital implemented Stratus® CS Acute Care Diagnostic Systems in the ED, saving time. With its hsTn test, proximity at the point of emergency patient care, and quick TAT, the protocol translated into meaningful results for patients.

Sep 01, 2011
Sample-to-Sample Carryover Is Insignificant When Sharing Serum Samples Between...
The ADVIA 1650 Chemistry System’s positive displacement sampling system with the integrated analyzer washing system is efficient in preventing sample-to-sample carryover in samples with high levels of infectious disease markers or tumor markers.

Sep 01, 2011
Validation of a Sex Hormone- Binding Globulin (SHBG) Assay on the ADVIA Centaur® Immunoassay System
The ADVIA Centaur® SHBG Immunoassay is a precise method for measuring SHBG in serum across a wide range of clinically relevant concentrations and shows good correlation with the Roche ELECSYS 2010 SHBG assay on adult and pediatric samples.

Aug 16, 2011
Development of a hypoxia gene expression classifier with predictive impact for hypoxic…
Cancer Res: RNA was extracted from a cohort of 323 head/neck squamous cell carcinoma (HNSCC) FFPE tissue samples using TPS. The investigators applied a 15-gene RNA expression classifier with real-time, two-step RT-PCR.

Aug 01, 2011

Extension of food allergen specific IgE ranges from the ImmunoCAP® to the IMMULITE® systems

Ann Allergy Asthma Immunol: R G. Hamilton et al found that specific IgE levels to egg white, milk and peanut measured by the IMMULITE® and ImmunoCAP® systems are highly correlated and that differences between the systems are circumscribed and are modest.

Aug 01, 2011
Faster bilirubin results allow rapid patient treatment at St. Michael's Neonatal ICU
Staff in the neonatal ICU at NHS St. Michael’s Hospital, Bristol, are now able to obtain bilirubin test results in 60 seconds using the RAPIDLab® 1265 Blood Gas analyzer.

Aug 01, 2011
Growth Diagnostics: Significance of GH, IGF-I, and IGFBP-3
Insulin-like Growth Factor-I and circulating Insulin-like Growth Factor Binding Protein-3 mediate the growth-inducing functions of GH.The publication also defines criteria for treatment outcomes based on GH, IGF-I, and MRI data.

Aug 01, 2011
Partnering for Better Pregnancy and Blood Gas Testing
An NHS 1600 bed hospital system uses RAPIDComm Data Management System to help its POC partners reduce clinical incidents, ensure quality, and improve productivity in critical care testing. A single interface manages pregnancy and blood gas testing.

Aug 01, 2011

Role of parenting style in achieving metabolic control in adolescents with type 1 diabetes

Diabetes Care: Parents completed assessments of their parenting style and sense of helplessness. Parents and patients rated patient adherence to the treatment regimen. Glycemic control was evaluated by HbA1c values, determined using a DCA 2000 Analyzer.

Aug 01, 2011

Youth and parent knowledge about major complications of type 1 diabetes: diabetes outcomes

Diabetes Care: Analyses explored knowledge and positive family communication as predictors of T1D outcomes (including HbA1c, measured using a DCA 2000+ Analyzer). Frequent optimistic family communication about MC was associated with more favorable status.

Jul 14, 2011

Glomerular filtration rate estimation: performance of serum cystatin C-based prediction equations

Clin Chem Lab Med.: Diabetes mellitus, cystic fibrosis, kidney transplantation, HIV-infection, and cirrhosis are clinical situations where cystatin C-based equations can be useful. Extremes of age have also been evaluated with favorable results.

July 01, 2011
Comparison of two real-time RT-PCR-based systems for the detection and typing of influenza A Virus
A new multiplex real-time RT-PCR distributed by Astra Diagnostics, coupled with the extraction system developed and commercialized by Siemens (referred to as the RealStar system), was tested for the ability to detect and type influenza A…

Jul 01, 2011
Endothelial CCR2 signaling induced by colon carcinoma cells enables extravasation via JAK2-Stat5…
Cancer Cell: TPS eluates obtained from mouse FFPE tissue samples were used for RNA expression analysis of cancer genes.

Jul 01, 2011
Nanotechnology speeds DNA, RNA extraction from tissue: Siemens Tissue Preparation Solution
Nanotechnology speeds DNA, RNA extraction from tissue through its fully automated, walkaway method for extracting nucliec acids from histopathological tissue samples.

Jul 01, 2011

Prediction of adolescents' glycemic control 1 year after diabetes-specific family conflict…

Arch Pediatr Adolesc Med: HbA1c levels in study subjects were measured using a DCA 2000+ Analyzer. Diabetes-specific family conflict in adolescence was found to predict deteriorations in BGM and subsequent glycemic control for at least 1 year.

Jun 29, 2011

Education programme...improves glycaemic control in Malaysians with poorly controlled diabetes

Health Educ. Res: HbA1c levels in subjects were measured using a DCA 2000 Analyzer. Self-care practices followed by subjects led to improvements in physical activity, self-monitoring of blood glucose, medication adherence, and HbA1c levels.

Jun 21, 2011

Quality error rates in point-of-care testing

Clin Chem: This study assessed a wide range of POCT methods across three study sites, including HbA1c testing on the DCA 2000 analyzer. An established Quality Query reporting system was used to log and investigate all quality errors associated with POCT.

Jun 01, 2011
Anti-CCP: An Important Aid in Rheumatoid Arthritis
Levels of anti-CCP are predictive of the development of rheumatoid arthritis, are associated with disease severity and progression, and are more specific for diagnosis.

Jun 01, 2011

CMV Diagnosis and CMV IgM

CMV IgM is a valuable tool that aids in the diagnosis of CMV infection. CMV IgM testing, when combined with the IMMULITE® 2000 CMV IgG assay and other IMMULITE 2000 TORCH tests, helps laboratories consolidate TORCH testing.

Jun 01, 2011
Prostate-Specific Antigen (PSA) Remains Relevant in the Early Detection of Prostate Cancer
Insights into the Results of the European Randomized Study of Screening for Prostate Cancer (ERSPC) and Prostate, Lung, Colon, and Ovary (PLCO) Screening Trial Studies

May 17, 2011

A novel C2 transferrin variant interfering with the analysis of carbohydrate-deficient transferrin

Clin Chim Acta: CDT is used as a marker for chronic alcohol abuse. Transferrin T139M, present as a heterozygous genotype, interferes with CDT analysis by HPLC and CZE but not by immunochemistry. Physiologically, it appears to be functionally normal.

May 05, 2011

Consensus recommendations for the uniform reporting of clinical trials: report of the Int'l Myeloma

Blood: A panel of members of the 2009 International Myeloma Workshop developed guidelines for standard investigative workup of patients with suspected multiple myeloma. Both serum and urine should be assessed for monoclonal protein.

May 01, 2011
Coagulation assays based on the Luminescent Oxygen Channeling Immunoassay technology.
Clin Chem Lab Med: LOCI® technology has potential to be used in functional blood coagulation testing in the central laboratory & in POC settings. LOCI technology with a flexible coag assay principle allows the design of a wide range of coagulation assays.

May 01, 2011

Estimating glomerular filtration rate in diabetes using serum cystatin C

Clin Biochem: Recent studies have suggested that estimates of GFR based on serum cystatin C concentration might provide a simple and accurate method for detecting and monitoring an early decline in renal function.

May 01, 2011
Prognostic utility of β-tubulin isotype III in early breast cancer: a translational HeCOG study.
BCRT: Sufficient yields of RNA were isolated using TPS from individual 10 µm FFPE tissue sections from 314 breast cancer samples that had been stored for up to 20 years.

Apr 01, 2011
Rapid, reliable results help enhance patient care in a rural hospital
A North Carolina 110 bed public hospital reduced turnaround time by 50 percent for critical IA assays with LOCI® on Dimension® EXL™, an integrated system.

Mar 01, 2011
Diagnostic management of acute venous thromboembolism during pregnancy: recent advancements…
Thrombosis Research: Accurate diagnostic management of VTE is of great importance during pregnancy. Studies have shown... a need of a structured diagnostic algorithm for the diagnostic management of suspected PE during pregnancy.

Mar 01, 2011
Quantitative determination of estrogen receptor, progesterone receptor, and HER2 in FFPE tissue…
Diagn Mol Path: TPS successfully extracted RNA with low section-to-section variability from 501 FFPE breast cancer samples that had been stored for up to 21 years. TPS proved to be a “reliable high-throughput instrument for standardized testing of…

Feb 01, 2011
Assessment of HER2 expression on protein and mRNA level: prediction of chemotherapy response…
Breast Cancer Res Treat: TPS was used to extract RNA from 278 individual FFPE breast cancer needle biopsies that had been stored up to 10 years. All eluates had a 100% success rate for RNA expression analysis studies with real-time, one-step RT-PCR.

Feb 01, 2011
Keeping up with Allergy testing
MLO:Studies indicate that 3rd gen allergy blood tests for detecting allergies common in children, including peanuts, insect venoms, milk, foods, and dust may have higher rates of precision, sensitivity, and safety, than other diagnostic options.

Feb 01, 2011
Providing Effective Blood Gas Testing and Data Management at Memorial University Medical Center
A 535 bed Georgia hospital uses RAPIDLab® analyzers with RAPIDComm® interface to provide an all-inclusive test menu, facilitate patient identification at the bedside, upload results to the electronic record and enable automatic billing upon completion.

Feb 01, 2011

The ABCs of diabetes: Diabetes education program for African Americans affects A1c, and ED visits

Diabetes Educator: A DCA 2000 Analyzer measured HbA1c. Diabetes Education classes for African-Americans at a public library significantly affected 6-month clinical outcomes, including a reduction in A1c.

Feb 01, 2011
The Advantages of Automatic Quality Control (AQC) for Blood Gas Testing QC
Cartridge-based system provides QC in a standardized and unique manner that removes the need for the operator intervention. Automatic Quality Control system ensures the running of specific levels of QC at specified time intervals.

Feb 01, 2011
Tracking Down Diabetes
From the Australia Outback to urban settings, the DCA Vantage® Analyzer helps diabetes management. Decreasing HbA1c levels from more than 8.8% to 7.3%, can lead to a reduction in long-term treatment costs and improved patient health.

Jan 20, 2011

Point-of-care testing for HbA1c in the management of diabetes: A systematic review and metaanalysis

Clin Chem: The authors performed a systematic review of trials to determine whether POCT for HbA1c, compared with lab testing, improves outcomes for patients with diabetes. The DCA 2000 was employed to measure HbA1c levels in 5 of the 7 trials assessed.

Jan 03, 2011
Kids speaking up about allergies
Parents may be unaware that allergic diseases, such as food allergies, rashes (allergic dermatitis) and recurrent ear infections, especially otitis media, can progress to asthma. There is a simple option for children to be tested for allergic reactions.

Jan 01, 2011

Accuracy of 25-hydroxyvitamin D assays: confronting the issues

Curr Drug Targets: Most LC/MS/MS assays are possibly overestimating 25(OH)vitamin D by failing to resolve a molecule having the same mass as 25(OH)vitamin D3 and a similar fragmentation pattern.

Jan 01, 2011

Accuracy of a continuous non-invasive hemoglobin monitor in intensive care unit patients

Critical Care Medicine: Hgb values were compared from HemoCue Hb 301 POCT analyzer, RAPIDPoint® 405 “satellite” analyzer, and Sysmex XT-2000i. Pulse CO-oximetry showed similar trend accuracy as “satellite” testing, whereas the POCT device did not.

Jan 01, 2011
Analytical performance and concordance: CA 15-3, CA 19-9, CA 125 II…on Dimension Vista® System
Clin Biochem: Measurement of CA 15-3, CA 19-9, CA 125 II, CEA and AFP on the Dimension Vista® System is an attractive alternative.Serial monitoring provides important insight into disease recurrence, remission or stability.

Jan 01, 2011

Assessment of a whole blood neonatal bilirubin method on the RAPIDPoint® 405 instrument versus…

AACC poster compared a whole blood neonatal bilirubin method to plasma nBili analysis on the VITROS 950 system. The method provided analytical results similar to the reference VITROS plasma chemistry method with no need for pre-analytical centrifugation.

January 01, 2011
Clinical implications of the change of troponin I levels—An evaluation with respect to the UDMI

Clin Chim Acta: A peak cTnI level above the 99th percentile together with a cTnI change of ≥20% within 24 hours of admission led to a significantly raised mortality over the study period of 5.8 years.

Jan 01, 2011

Comparison of new monoclonal assays for FLC κ and λ to polyclonal assays and electrophoresis

Clinical comparison of new monoclonal antibody-based nephelometric assays for free light chain kappa and lambda to polyclonal antibody-based assays and immunofixation electrophoresis.

Jan 01, 2011

Comparison of two point-of-care testing (POCT) devices for fetal lactate during labor

Clin Chem Lab Med: This study evaluated the analytical performance of two POCT lactate meters against a reference RAPIDLab® 860 analyzer. Overall performance of both the Lactate Pro and StatStrip lactate meters showed good correlation to Siemens’ reference.

Jan 01, 2011

Evaluation of two HbA1c point-of-care analyzers

Clin Chem Lab Med: DCA Vantage and Axis Shield Afinion POCT analyzers were evaluated for bias and precision as well as interference from carbamylated hemoglobin. Both analyzers for HbA1c showed good correlation with the lab method and acceptable precision.

Jan 01, 2011

Hemoglobin A1c and mean glucose in type 1: JDRF continuous glucose monitoring randomized trial

Diabetes Care: DCA 2000 Analyzer measured HbA1c. Substantial variability between measured versus calculated mean glucose concentrations was found. "Estimated average glucose concentrations calculated from measured HbA1c values should be used with caution.”

Jan 01, 2011
Laboratory Testing: An essential component of thyroid disease diagnosis and management.
Thyroid tests are essential for the diagnosis and monitoring of hyperthyroidism and hypothyroidism, in aiding diagnosis and follow-up of patients with medullary cancer, and in the follow-up of patients with differentiated thyroid cancer.

Jan 01, 2011

Mitochondrial capacity is affected by glycemic status in young untrained women with type 1…

Am J Physiol Regulatory Integrative Comp Physiol: Authors examined if glycemic status influences aerobic function in women with type 1 diabetes, and whether aerobic function is reduced relative to healthy women. A DCA 2000 Analyzer determined HbA1c levels.

Jan 01, 2011

N Latex FLC - new monoclonal high-performance assays

Clin Chem: N Latex FLC demonstrates high precision, good lot-to-lot consistency and freedom from a high-dose hook effect. The method comparison between Freelite™ and the N Latex FLC assays showed good clinical concordance.

Jan 01, 2011

Retrospective analysis of 55,769 HbA1c EQA results from labs and offices participating in surveys

J of Clin Lab Analysis: Compared EQA HbA1c results obtained between 1999 and 2008. The best global precision performances were obtained by professional labs and offices using DCA POCT devices. DCA POCT devices had better reproducibility than lab devices.

Jan 01, 2011

The 2011 report on dietary reference intake for vitamin D: where do we go from here

JCEM: Paper is a review of the Institute of Medicine (IOM) report on dietary reference ranges (DRI) and its implications. Only bone health could be used as an indicator for DRI development. 2010 Vitamin D Expert Consensus Panel recommends 30 ng/mL.

Jan 01, 2011
The new INNOVANCE® PFA P2Y cartridge is sensitive to the detection of P2Y12 receptor inhibition.
Platelets: INNOVANCE® PFA P2Y* showed a high sensitivity for the detection of P2Y12 receptor blockade. This new cartridge is a useful tool to rule out P2Y12 receptor inhibition, if normal or only slightly prolonged CTs are obtained.

Dec 23, 2010
Dendrimers and their applications in immunoassays and clinical diagnostics
Biotechnol Appl Biochem:A review of the synthesis and properties of a unique class of nanoscopic macromolecules exploited in the development of sensitive immunoassays, including dendrimer-coupled antibody reagents utilized in Stratus CS assays.

Dec 01, 2010
A New Aid for Identifying Sepsis
Measurement of BRAHMS procalcitonin aids clinicians in identifying patients with sepsis and has also been shown to reduce unnecessary antibiotic use. The positive outcomes experienced are confirmed by a multicenter study conducted in Switzerland.

Dec 01, 2010

Hemoglobin A1c: Assessment of three POC analyzers relative to a central laboratory method

Clin Chim Acta: Random samples analyzed for HbA1c using the Bio-Rad Variant II were run on three POC analyzers (DCA Vantage®, Axis-Shield Afinion, and Bio-Rad In2it analyzers). All POC instruments showed good correlation to the central lab method.

Dec 01, 2010
Sustainable Change
Portugal’s Dr. Joaquim Chaves reference laboratory became more productive with automation – and more competitive. It now uses less water, saves on material costs, and generates less waste, enabling it to sustainably contribute to environmental protection.

Dec 01, 2010
The VersaCell® System: A case study Hospital La Inmaculada de Huércal-Overa
Spanish lab employs a unique solution to optimize immunoassay testing. The consolidation that the VersaCell™ system made possible for radically different specialty IA testing areas like ID testing, allergy testing, and maternal screening, is very unique.

Nov 24, 2010

Effects of aerobic and resistance training on HbA1c levels in type 2: Randomized controlled trial

JAMA: HbA1c levels were measured over a 9-month period using a DCA 2000+ Analyzer. Among patients with type 2 diabetes, a combination of aerobic and resistance training compared with the nonexercise control group improved HbA1c levels.

Nov 01, 2010
ADVIA Centaur® Free PSA Assay:* Performance and Clinical Utility
The free PSA assay demonstrated excellent performance characteristics. ADVIA Centaur® percent free PSA ratios were comparable to Siemens IMMULITE® 2000 and Beckman Coulter Access® 2 percent free PSA ratios.*Not Available in the U.S.

Nov 01, 2010

Hemoglobin A1c is a reliable criterion for diagnosing type 1 diabetes in childhood and adolescence

Pediatr Diabetes: This study investigated the sensitivity and specificity of HbA1c at onset of childhood type 1 diabetes using the DCA 2000 Analyzer. Sensitivity was 100%, and specificity of HbA1c as a diagnostic criterion was 100%.

Nov 01, 2010
Remote monitoring and proactive service minimizes downtime and provides uninterrupted workflow
BCS XP System provides the 320 bed Lawrence and Memorial Hospital State-of-the-Art Intelligent Device Management.

Oct 29, 2010

First certified reference material for cystatin C in human serum ERM-DA471/IFCC

Clin Chem Lab Med: The IFCC Working Group for the Standardisation of Cystatin C (WG-SCC), in collaboration with the Institute for Reference Materials and Measurements (IRMM), announces availability of the new certified reference material ERM-DA471/IFCC.

Oct 19, 2010

Diabetes control with reciprocal peer support versus nurse care management: A randomized trial

Ann Intern Med: The authors compared a reciprocal peer-support program with a nurse care management program. HbA1c levels were measured using a DCA 2000 Analyzer. Reciprocal peer support holds promise as a method for diabetes care management.

Oct 18, 2010
In Vitro Methods for Diagnosing Allergy and Directing Therapy
In vitro blood testing can be requested by any physician. In vitro testing carries fewer risks and discomfort for the patient, and has been shown to be comparable in sensitivity and specificity to skin testing.

Oct 01, 2010
Procalcitonin: A New Tool for Sepsis
PCT measurements can aid clinicians in making the diagnosis of sepsis and can provide information about patient prognosis.

Oct 01, 2010
The VersaCell™ System: A case study Lewis County General Hospital
Community hospital lab benefits with VersaCell™ automation.

Sep 14, 2010

Guidelines on the diagnosis and management of multiple myeloma

BCSH and UKMF Guidelines: Quantification of SFLC levels and κ/λ ratio is an additional tool for the assessment of light chain production. The serum tests are particularly useful for diagnosis and monitoring of light chain only myeloma...

Sep 01, 2010
Automating Nucleic Acid Isolation... Improves Assay Performance in the Molecular Diagnostics Lab
A new methodology,incorporating a modified bead composition and nanotechnology, permits high pipetting reproducibility, quick magnetization, good particle suspension behavior, and high purification yields.

Sep 01, 2010
An intelligent lab system revolutionizes the way a lab functions: Case Study
A 323 bed Detroit hospital added Dimension® Vista® with LOCI® to do more tests onboard, consolidate tests to one instruments, and increase test capacity without adding staff.

Sep 01, 2010

Parental involvement and adolescents’ diabetes management: The mediating role of self-efficacy…

J Pediatr Psychol: HbA1c levels were measured using a DCA 2000 Analyzer. Quality of the parent–adolescent relationship and monitoring are important for better adherence and metabolic control among adolescents through higher diabetes self-efficacy.

Sep 01, 2010
The VersaCell™ System: A case study Medical Center Alkmaar (MCA)
96 percent of ID serology testing available on the VersaCell™ System

Sep 01, 2010

Vit D and musculoskeletal health, cardiovascular disease, autoimmunity and cancer: recommendations…

Autoimmun Rev: Reported patient values should be a single total 25(OH)vitamin D assay reported in ng/mL, measuring both 25(OH)vitamin D2 and 25(OH)vitamin D3. Serum is the recommended sample type.

Aug 01, 2010

A randomized controlled trial comparing motivational interviewing to structured education in teens

Diabetes Care: A DCA Vantage Analyzer was used to determine HbA1c levels in study subjects. Structured diabetes education was found to be effective at improving metabolic control in adolescents with type 1 diabetes.

Aug 01, 2010
IMMULITE® HCG and Subunits: Assay Specificities and Clinical Utility in Obstetrical Care
Commercial assays for HCG have different antibody specificities; these differences must be recognized to achieve consistent and reliable HCG results. IMMULITE® HCG assay measures both intact and nicked forms of HCG and unnicked and nicked free β subunit.

Aug 01, 2010
New Diagnostics Solutions Enhance Laboratory Productivity
At the U.K.'s University Hospitals of Leicester and Friarage Hospital, ADVIA CentraLink with ADVIA® LabCell® Automation Solution and VersaCell® System improves access to audit trail data, faster throughput, reduced errors, and greater efficiency.

Jul 22, 2010

Adolescent and parent perceptions of patient-centered communication while managing type 1 diabetes

J Pediatr Psychol: Adolescents’ and parents’ perceptions of patient-centered communication with the physician may be associated with aspects of patient empowerment and diabetes management. HbA1c levels were measured using a DCA 2000 Analyzer.

Jul 22, 2010

From caregiver psychological distress to adolescent glycemic control: The role of perceived burden

J Pediatr Psychol: HbA1c levels were measured using a DCA 2000+ Analyzer. The study found that a variable linking caregiver psychological distress to adolescent glycemic control is the perceived caregiver burden associated with diabetes management.

Jul 06, 2010

Serum free light chain analysis

Am J Hemat: The recent development of a robust assay known as λ and κ ‘‘free’’ LC (FLC) to quantify the levels of these unbound LC in the serum, and determine their ratio, has led to studies that demonstrate utility in a wide range of hematologic...

Jul 01, 2010
PATHFAST NT-proBNP: a multicenter evaluation of a new POC assay
Clin Chem Lab Med: A multicenter evaluation assessed a new POC testing PATHFAST NT-proBNP assay. The assay was evaluated against Siemens NTproBNP assay running on the Stratus® CS System. Satisfactory analytical and clinical performance was observed.

Jul 01, 2010

Psychosocial well-being and functional outcomes in youth with type 1 diabetes 12 years after onset

Diabetes Care: Collected data included HbA1c levels as measured on a DCA 2000 Analyzer. Psychiatric morbidity was associated with poor metabolic control and failure to transition to tertiary adult diabetes care.

Jun 25, 2010

Use of HbA1c in screening for Cuban-Americans with undiagnosed type 2 diabetes

J Immigr Minor Health: This study evaluated HbA1c testing on the DCA 2000+ Analyzer as a screening tool for undiagnosed type 2 diabetes. HbA1c is a reliable alternative to fasting plasma glucose in screening for undiagnosed diabetes in Cuban-Americans.

Jun 10, 2010

Community-based diabetes education for Latinos: The Diabetes Empowerment Education Program

The Diabetes Educator: Diabetes education delivered by community health workers was evaluated for improving glycemic control and self-management skills in Hispanics/Latinos with type 2 diabetes. HbA1c levels were measured on a DCA 2000+ Analyzer.

Jun 01, 2010

The role of adjunctive Exenatide therapy in pediatric type 1 diabetes

Diabetes Care: This study aimed to determine an effective, safe glucose-lowering adjuvant exenatide dose in youths with type 1. A DCA 2000 Analyzer measured HbA1c. Adjunctive exenatide therapy reduces postprandial hyperglycemia in adolescents with type 1.

May 31, 2010

Vitamin D and chronic kidney disease

Ethn Dis:Low levels of vitamin D are associated with progression of CKD and cardiovascular complications. Minority populations are at special risk for hypovitaminosis D and progression of CKD to end-stage renal disease.

May 01, 2010

A personalized approach to exercise promotion in adolescents with type 1 diabetes

Pediatr Diabetes: This study measured HbA1c levels in diabetic patients who were encouraged to exercise to reduce cardiovascular risks. Levels remained unchanged.

May 01, 2010

Early pharmacokinetic and pharmacodynamic effects of mixing Lispro with Glargine insulin: Type 1...

Diabetes Care: A DCA Vantage Analyzer measured HbA1c. Mixing Lispro with Glargine flattens the early
peak of Lispro and causes a right shift in the glucose infusion rate curve. This might lead to difficulties in controlling meal-related glucose excursions.

May 01, 2010

Pediatric reference intervals for IgG and its subclasses with Siemens immunonephelometric assays.

Clin Biochem: Our data provide the missing pediatric reference intervals and enable the use of the nephelometric IgG subclass reagents in children and adolescents.There was excellent correlation between the total IgG and the sum of the IgG subclasses.

May 01, 2010

Racial disparity in A1c independent of mean blood glucose (MBG) in children with type 1 diabetes

Diabetes Care: African-Americans had significantly higher A1c and Hgb glycation index than Caucasians. Because of racial disparity in A1c, which is independent of MBG, the authors recommend that A1c and MBG be used together to make therapeutic decisions.

Apr 08, 2010

Responsibility sharing between adolescents with type 1 diabetes and their caregivers...

J Pediatr Psychol: A DCA 2000+ Analyzer was used to measure HbA1c levels. Analyses demonstrated that adolescent perception of greater responsibility sharing with caregivers on direct management tasks was significantly associated with higher BGM frequency.

Apr 01, 2010

3-year follow-up of clinical and behavioral improvements following a multifaceted diabetes care…

Diabetes Educator: Randomized controlled trial determined improvements observed at 12-month follow-up in glycemic and blood pressure control were sustained at 3-year follow-up. HbA1c levels were measured using a DCA 2000 Analyzer.

Apr 01, 2010

Evaluation of the in2it analyzer for HbA1c determination

Diabetes Metab: Bio-Rad in2it was evaluated against a DCA® System. Correlation was satisfactory, although in2it analyzer “software specifications need to be upgraded, especially for quality control management, traceability of results and data safety.”

Apr 01, 2010
Immunoassays for diagnosis of coagulation disorders.
Hämostaseologie: Technical and performance aspects of those immunoassay technologies that are most widely used in the coagulation laboratory, and descriptions of markers that are typically tested by immunoassays.

Apr 01, 2010
Laboratory diagnosis of von Willebrand disease.
Hämostaseologie: Considerable progress has been made in the laboratory diagnosis of VWD in the recent years. Genetic testing and multimer analysis as well as the VWF propeptide assay increasingly support the differentiation of von Willebrand types.

Apr 01, 2010

Recombinant phospholipase A1 (Ves v 1) from yellow jacket venom for improved diagnosis of…

Clin Mol Allergy: IgE reactivity of sera of YJV-sensitized and double-sensitized patients emphasised the relevance of Ves v 1. Combined use of both molecules enabled a reliable assignment of sensitisation to YJV for more than 90% of these patients.

Apr 01, 2010

Technical performance of lactate biosensors and a test-strip device during labor

Z Geburtshilfe Neonatal: Three lactate analyzers and a test strip device were evaluated regarding precision in serial and repetitive measurements in over 1350 samples of fetal whole blood. All tested biosensors showed sufficient precision.

Mar 01, 2010

Active care management supported by home telemonitoring in veterans with type 2 diabetes…

Diabetes Care: DiaTel randomized controlled trial. Compared with the telephone call group, the active care management with home telemonitoring group demonstrated significantly greater reductions in A1c, measured by a DCA 2000 Analyzer.

Mar 01, 2010

Development and validation of a questionnaire on carbohydrate and insulin-dosing knowledge in type 1

Diabetes Care: The PedCarbQuiz (PCQ) assesses carbohydrate and insulin-dosing knowledge in youth with type 1 diabetes. Scores were correlated with HbA1c levels measured by HPLC and a DCA 2000 Analyzer. Higher PCQ scores correlated with lower HbA1c.

Mar 01, 2010

Racial and ethnic differences in an estimated measure of insulin resistance in type 1 diabetes

Diabetes Care: HbA1c and urinary albumin and creatinine levels were measured using a DCA 2000+ Analyzer. Minorities with type 1 diabetes were found to be significantly more insulin-resistant, as measured by estimated glucose disposal rate, than NHWs.

Mar 01, 2010

Six months of Diazoxide treatment at bedtime in newly diagnosed subjects with type 1 diabetes…

Diabetes Care: A DCA 2000 Analyzer measured HbA1c. Diazoxide treatment reduced A1c from baseline 8.6% to 6.0% at 6 months and 6.5% at 12 months. Six months of low-dose diazoxide was without side effects and was associated with improved metabolic control.

Feb 28, 2010

The structure of parental involvement and relations to management for youth with type 1 diabetes

J Pediatr Psychol: The authors examined associations of parental involvement with adherence and metabolic control. HbA1c levels were measured using a DCA 2000 Analyzer. The study found that higher reports of paternal monitoring were related to lower HbA1c.

Feb 08, 2010

Parental involvement buffers associations between pump duration and metabolic control with type 1

J Pediatr Psychol: HbA1c levels (obtained from medical records) were measured on a DCA 2000 Analyzer. The study found that adolescents on continuous subcutaneous insulin infusion displayed better HbA1c than those on multiple daily injections.

Feb 01, 2010
Comparison of platelet function tests in predicting clinical outcome in patients undergoing stent...
JAMA: Light transmittance aggregometry,Verify Now, Platelet works, and Innovance PFA P2Y were significantly associated with the primary end point.

Feb 01, 2010

Effects of long-term Fenofibrate treatment on renal function in type 2: The FIELD Helsinki substudy

Diabetes Care: A DCA 2000+ Analyzer measured HbA1c. Blood pressure and fasting glucose decreased, while A1c remained at 7.2%. Decreases in creatinine clearance and eGFR by fenofibrate “complicate the clinical surveillance during Fenofibrate treatment.”

Jan 01, 2010
ADVIA® Automation Solution: A case study – Fürst Medical Laboratory
Automation helps a mega-laboratory process 12,000,000 tests with one solution.

Jan 01, 2010

Alteration of biological markers in alcohol-dependent individuals without liver disease during detox

In Vivo: The need for sensitive biological markers to detect and prove recent drinking has been the focus of many research groups.CDT is an excellent marker of alcohol overconsumption during evaluation, as well as during the detoxification treatment.

Jan 01, 2010
Automated extraction of DNA and RNA from a single FFPE tissue section for analysis of both...
Clin Chem: 210 FFPE samples that had been stored for up to 25 years were processed with TPS using the split protocol (delivering both DNA and RNA in separate eluates from a single sample). TPS provided extracts with a success rate of 99% for combined analysis…

Jan 01, 2010
Comparison of Whole Blood Total Bilirubin Determination in Neonates
Analysis of unhemolyzed whole blood using the RAPIDLab® 1265 Blood Gas System is a clinically acceptable method for monitoring the development of pathologic concentrations of bilirubin in neonates.

Jan 01, 2010
Cystatin C for renal function and cardiovascular risk assessment
By providing an earlier indication of relatively small decreases in GFR, studies are indicating Cystatin C to be superior to creatinine in detection of kidney disease and in risk assessment for heart failure, hypertension, diabetes, and even death.

Jan 01, 2010

Development of the ADVIA Centaur® Vitamin D Total Assay

Data obtained with the ADVIA Centaur® Vitamin D Total assay demonstrated equimolar detection of 25(OH)D2 and 25(OH)D3 and showed traceability to LC-MS/MS.

Jan 01, 2010

Diabetes-specific family conflict and blood glucose monitoring in adolescents With type 1 diabetes…

Diabetes Spectr: A DCA 2000+ Analyzer measured HbA1c levels. Results confirmed a partial mediational role of diabetes self-efficacy and suggest that a family environment characterized by conflict may also contain poorer self-efficacy in the adolescent.

Jan 01, 2010

Effectiveness of continuous glucose monitoring in a clinical care environment: JDRF…

Diabetes Care: JDFR Continuous Glucose Monitoring Trial studied if CGM is effective in the management of type 1 diabetes when implemented in a manner that more closely approximates clinical practice. HbA1c levels were measured using a DCA 2000 Analyzer.

Jan 01, 2010

EPO and vascular endothelial growth factor (VEGF) as risk markers for severe hypoglycaemia in type 1

Eur J Endocrinol: HbA1c levels in patients were measured using a DCA 2000 Analyzer. Results did not support random VEGF or EPO levels to determine future risk of severe hypoglycaemia.

Jan 01, 2010
Evolution of TSH Assays: A Third Generation Viewpoint
3rd gen assays have far superior precision in the subnormal TSH range (0.1 to 0.4 μIU/mL) compared to 2nd gen assays. The ATA has recommended using both a sensitive TSH assay and a free thyroxine estimate to confirm thyroid abnormalities.

Jan 01, 2010
Hormonal Levels During the Early Follicular Phase of the Menstrual Cycle
FSH and estradiol are common choices for monitoring during the early follicular phase of women receiving ovarian hyperstimulation and IVF. Levels of these hormones are then evaluated with respect to the achievement of pregnancy.

Jan 01, 2010
Performance Evaluation of the TSH3-Ultra Assay on the ADVIA Centaur® and ADVIA Centaur® CP Systems
The ADVIA Centaur® TSH3-Ultra assay is sensitive and precise, with imprecision performance that exceeds the NACB criteria. Innovations have allowed a higher TSH sensitivity detection, wider liner range, and a reduction in sample volume to 100 μL.

Jan 01, 2010
Taking the pain out of allergy testing
Early identification of childhood allergies and immunotherapy may halt the allergy march and reduce morbidity due to allergies.Third generation allergy blood tests are highly sensitive and provide a quantitative result.

Jan 01, 2010

Tumor-associated lymphocytes as an independent predictor of response to neoadjuvant chemotherapy...
JCO: RNA was extracted from 1058 breast cancer needle biopsy FFPE samples that had been stored for up to 10 years. TPS eluates had a success rate of 100% for both extraction and RNA expression analysis with real-time, one-step RT-PCR.

Dec 10, 2009

Alcohol biomarkers as tools to guide and support decisions about intoxicated driver risk

Traffic Inj Prev: Biomarker testing improved the assessment and monitoring of repeat offenders because it provided an objective tool to identify high-risk drivers allowing for better treatment recommendations and helped identified drivers who relapsed...

Dec 01, 2009
Association of cyclooxygenase-1-dependent and -independent platelet function assays…
Circulation: Poor clinical outcome in aspirin-treated patients has been termed aspirin resistance and may result from inadequate inhibition of platelet cyclooxygenase-1 (COX-1) by aspirin.

Dec 01, 2009
Lab Mechanics
An automated, integrated system helps the clinical laboratory at White Plains Hospital in New York achieve performance, business, and patient safety objectives.

Nov 01, 2009
Gender differences in correlates of troponin assay in diagnosis of myocardial infarction
Transl Res: This study assessed the accuracy and correlates of troponin I (cTnI) assay on the Stratus® CS System in the diagnosis of non-ST-segment elevation MI. No significant difference in the assay sensitivity or specificity by gender was observed.

Oct 01, 2009

A pilot study of observed parenting and adjustment in youths with type 1 diabetes and their mothers

J Pediatr Psychol: HbA1c levels were measured using a DCA 2000 Analyzer. Higher observed child-centered parenting, positive reinforcement, and lower levels of maternal hostility were related to better psychosocial adjustment and better metabolic control.

Sep 15, 2009

The relationship between hemoglobin levels and endothelial functions in diabetes mellitus

Clin J Am Soc Nephrol: The relationship was investigated between Hb and flow-mediated dilation (FMD) levels of patients with diabetic nephropathy. HbA1c levels were determined using DCA 2000 Analyzer. FMD was found to be inversely related with Hb levels.

Sep 10, 2009

A high-sensitivity, medium-density and target amplification-free planar waveguide microarray

Clin Chem: TPS was used to extract RNA from FFPE tissue samples. The extracted RNA was applied to an amplification-free, planar waveguide microarray system for gene expression analysis.

Sep 02, 2009
CDK10 is not a target for aberrant DNA methylation in breast cancer.
Anticancer Res: TPS was used to extract RNA from 96 FFPE cancer tissue sections. All eluates were analyzed with real-time, one-step RT-PCR.

Sep 01, 2009
A Simple Blood Test Takes the Guesswork out of Allergy Diagnosis
Determining the cause of an allergic reaction has been a diagnostic challenge. Siemens’ 3gAllergy diagnostic test offers a simple, convenient, and accurate alternative to traditional skin testing.

Sep 01, 2009

Design, implementation and results of the QC program for the Australian government’s POCT...trial

Ann Clin Biochem: A controlled trial determined the clinical effectiveness, cost-effectiveness, satisfaction, and safety of point-ofcare testing in general practice. HbA1c and A:C testing on the DCA 2000 Analyzer met the analytical goals set for the trial.

Aug 14, 2009

Anxiety symptoms in adolescents with type 1 diabetes: Association with blood glucose monitoring

J Pediatr Psychol: Patient data collected included HbA1c levels as measured on a DCA 2000+ Analyzer. Anxiety symptoms are associated with less frequent BGM and suboptimal glycemic control in adolescents with type 1 diabetes.

Aug 10, 2009

Evaluation of a training program for device operators in the Australian Government's POCT trial

Rural Remote Health: A controlled trial determined the clinical effectiveness, cost effectiveness, satisfaction, and safety of POC testing in general practice. HbA1c and A:C ratio testing was conducted on the DCA 2000 Analyzer.

Jul 12, 2009

Comparison of urinary albumin excretion rate in overnight urine and ACR in spot urine…

Scand J Prim Health Care: Spot urine ACR on a DCA 2000 Analyzer can replace a timed (overnight) collection of urine and measurement of UAER when diabetic patients are reviewed in general practice.

Jul 01, 2009

Evaluation of a new HbA1c point-of-care analyser: Bio-Rad in2it compared to DCA 2000 and central lab
Ann Clin Biochem: Less than ideal precision performance of the Bio-Rad in2it analyzer and differences with the central laboratory analysers must be communicated to and noted by the users.

Jul 01, 2009
Nexus compares competing Immunoassay (IA) Systems that Perform Infectious Disease (ID) Testing
A Nexus third-party review of 4 competitive IA systems in mid-size hospitals, with “real-world” Infectious Disease testing worklists, compared value added features that improve workflow and overall operator interaction.

Jun 13, 2009

Reducing glycaemic variability in type 1 diabetes self-management with a continuous glucose…

Diabetologia: This study investigated the use of a continuous glucose monitoring system under home-use conditions in the self-management of type 1 diabetes. HbA1c (DCA 2000 Analyzer) was measured in 48 patients at the start and end of the study.

Jun 01, 2009

Alarming levels of carboxyhemoglobin in banked blood

J Cardiothorac Vasc Anesth: A study determined the level of carboxyhemoglobin found in banked blood in the Albany, NY region. The transfusion of packed RBC units may artificially elevate readings of COHb and cause confusion over possible causes.

May 14, 2009

Six of eight HbA1c POC instruments do not meet the general accepted analytical performance criteria

Clin Chem: The study investigated the conformance of 8 POCT instruments with generally accepted performance criteria for HbA1c. Only DCA Vantage® and Afinion analyzers met the acceptance criteria of having a total CV <3% in the clinically relevant range.

May 01, 2009
Age-adapted approach for the use of D-dimers in the exclusion of deep venous thrombosis.
Am J Hematol: The objective of this study is to evaluate the use of age-adapted cut-off values for three DD assays in symptomatic outpatients suspected for having deep venous thrombosis (DVT).

May 01, 2009

Early nephropathy in type 1 diabetes: the importance of early renal function decline

Curr Opin Nephrol Hypertens: Recent findings refine the existing paradigm of early nephropathy in type 1 diabetes. Clinical tests – such as an algorithm for the serial determination of serum cystatin C - should be developed...

May 01, 2009

Hemoglobin A1c point-of-care assays; a new world with a lot of consequences

J Diabetes Sci Technol: The in2it (Bio-Rad) and DCA Vantage analyzers were evaluated using CLSI protocols for HbA1c testing. To maintain the inter-laboratory CV of 5% for HbA1c, the CLIA rules for waived POC instruments should be revised.

Apr 01, 2009
C-Peptide: Roles in diabetes, insulinoma, hypoglycemia
This article provides a concise review of C-peptide production and physiology, explores its application in diabetes testing, and reviews its role in hypoglycemia and insulinoma. A comparison of C-peptide assays on the Siemens IA systems is also provided.

Apr 01, 2009
Key opinion: Microalbuminuria test methods
The ADA recommendations put a stronger emphasis on the albumin/creatinine ratio for spot samples as the preferred method. Without the creatinine ratio, the methods are more prone to false positives and false negatives due to the varying urinary output.

Apr 01, 2009

Reporting cerebrospinal fluid data: knowledge base and interpretation software

Clin Chem Lab Med: The widespread use of automated on-line evaluation programs can now be combined with knowledge-based programs for interpretation by clinical chemists and neurologists. Differences found in interpretation software are discussed.

Apr 01, 2009
Sepsis: Improving the odds
PCT is the precursor of calcitonin, a hormone produced in the thyroid gland. It is absent from the blood of healthy individuals. During an infection and subsequent inflammatory response, however, PCT levels increase exponentially over a wide range.

Mar 01, 2009
Assuring Control Quality for Quality Controls
The quality control process is often a balancing act. Laboratories want to perform enough testing to ensure quality care at the same time they want to avoid wasting resources on excessive and unnecessary testing.

Mar 01, 2009

Development and performance of an albumin-creatinine ratio assay on the Afinion AS100 analyzer

Point of Care: ACR performance on the Afinion AS100 analyzer when compared to DCA 2000 analyzer and Roche Modular analyzers demonstrated a linear CV of 0.99 for albumin (both methods) and 0.99 and 1.00, respectively, for creatinine.

Feb 01, 2009

Peanut allergy diagnosis in the context of grass pollen sensitization: roles of peanut and CCD sIgE 

Int Arch Allergy Immunol:The IMMULITE® 2000 system had better specificity than the ImmunoCAP® system for accurate diagnosis of peanut allergy in patients allergic to grass pollen. CCD sIgE was identified in most of the false positive peanuts sIgE results.

Jan 01, 2009
Achieving a six-fold increase in revenue without adding staff
Annual billings soar 554 percent after White Plains Hospital Center implements the ADVIA® Workcell® Automation Solution with CentraLink® while aliquoting was reduced by more than 94 percent.

Jan 01, 2009
Advanced laboratory automation manages soaring test volume while enhancing workflow
ADVIA® WorkCell® Automation Solution has significantly improved lab efficiency by limiting aliquoting to minimal volume after testing is complete.

Jan 01, 2009
C-peptide -- an intriguing molecule: assays on the ADVIA Centaur® and IMMULITE® systems
Studies have linked low levels of C-peptide to diabetes mellitus complications, and evidence suggests that maintaining higher levels of C-peptide is especially beneficial for type 1 diabetics.

Jan 01, 2009
Complexed PSA— Peer - Reviewed Clinical Studies
"Complexed PSA is as good as total PSA for determination of biochemical recurrence in patientsafter radical prostatectomy. Complexed PSA is a useful aid for monitoring patients after radical prostatectomy."

Jan 01, 2009

Hematocrit measurement: comparison of conductimetry to microcentrifugation

Ann Biol Clin: All models of analyzers tested, including the RAPIDPoint® 405 system, gave satisfactory performance when compared with microcentrifugation, referred to in this study as the “gold standard” for hematocrit determination.

Jan 01, 2009

IL-6 and LBP: Detection of Infection, Inflammation, and Sepsis
Graphs showing daily LBP and IL-6 profiles monitored in three general surgical patients illustrate how these biomarkers can reflect patient infection and immune function status (reference ranges: IL-6, <10 pg/mL; LBP, <15 mg/mL).

Jan 01, 2009
Including HER-2/neu in Metastatic Breast Cancer Monitoring
The Serum HER-2/neu test is used to monitor a patient’s HER-2/neu status after diagnosis of metastatic breast cancer has been established. A chart shows how the Serum HER-2/neu test is typically used as a monitoring tool complementary to tissue testing.

Jan 01, 2009

Leontio Lyceum Albuminuria (3L Study) epidemiological study: Aims, design and preliminary findings

Hellenic J Cardiol: This study evaluated the prevalence of microalbuminuria among Greek schoolchildren. This was determined as 12.9% in a sample group of 498 students.

Jan 01, 2009

RNA extraction from archival FFPE tissue: manual, semiautomated, and automated purification methods.

Clin Chem: In this method comparison study, Siemens fully automated TPS methods showed the best reproducibility and least hands-on and total times when extracted RNA from 90 FFPE tissue samples was used for expression analysis.

Jan 01, 2009
Sex Hormone Binding Globulin and the Assessment of Androgen Status
Carrier proteins such as sex hormone binding globulin (SHBG) have important roles in regulating the amount of unbound steroid in the blood. SHBG’s impact on steroid-mediated processes has attracted increasing attention.

Jan 01, 2009
Spanish hospital harnesses the power of ultra-integration
Spanish hospital harnesses the power of ultra-integration of multiple state-of-the-art technologies.

Jan 01, 2009
Use of Bio-Rad Lyphochek Immunoassay Plus Control... in the Siemens 3gAllergy Specific IgE Assays
In this study, using the Siemens IMMULITE® 2000 3gAllergy™ Specific IgE assays, the presence of specific IgE for 6 specific allergens (D1, D2, E1, G3, G6, and T3) was demonstrated in the commercially available Bio-Rad Lyphochek Immunoassay Plus Control.

Jan 01, 2009
VersaCell® System: Case Study at a Medium-Sized Hospital Laboratory in the Netherlands
The VersaCell® System from Siemens Healthcare Diagnostics allowed the clinical laboratory to process samples faster and reduce the amount of operator time required

Dec 23, 2008

NACB Practice guidelines: emerging biomarkers for primary prevention of CVD

Clin Chem: Based on a thorough review of the published literature, only hsCRP met all of the stated criteria required for acceptance as a biomarker for risk assessment in primary prevention.