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Learn more about external studies conducted on some of our key technologies and assays, including platelet function analysis, P2Y12 testing*, D-dimer testing, LOCI technology, and preanalytical variables in coagulation testing.

Platelet Function Analysis (Dade® PFA Collagen/EPI Test Cartridge)

A practical concept for preoperative identification of patients with impaired primary hemostasis.
Clin Appl Thromb Hemost. 2004 Jul;10(3):195-204.


A practical concept for preoperative management of patients with impaired primary hemostasis.
Clin Appl Thromb Hemost. 2004 Apr;10(2):155-66.

Platelet Function Analysis (Dade® PFA Collagen/ADP Test Cartridge)

Screening for von Willebrand disease with a new analyzer using high shear stress: A study of 60 cases.
Blood. 1998 Feb;91(4):1325-1331.


Clinical utility of the PFA-100.
Semin Thromb Hemost. 2008 Nov;34(8):709-33.


Platelet function in patients with acute coronary syndrome (ACS) predicts recurrent ACS.
J Thromb Haemost. 2006 Sep;4:1-6.


Association of cyclooxygenase-1-dependent and -independent platelet function assays with adverse clinical outcomes in aspirin-treated patients presenting for cardiac catheterization.
Circulation. 2009 Dec 22;120(25):2586-97.


The new INNOVANCE® PFA P2Y cartridge is sensitive to the detection of the P2Y12 receptor inhibition.
Platelets. 2011;22(1):19-25.


Comparison of platelet function tests in predicting clinical outcome in patients undergoing coronary stent implantation.

JAMA. 2011 Jun 1;305(21):2174.

von Willebrand (BC von Willebrand Reagent and INNOVANCE® VWF Ac Assay)*

Treatment of severe von Willebrand disease with a high-purity von Willebrand factor concentrate (Wilfactin): a prospective study of 50 patients.
J Thromb Haemost. 2007;5:1115–1124.


Novel gain-of-function mutations of platelet glycoprotein Iba by valine mutagenesis in the Cys209-Cys248 disulfide loop.
J Biol Chem. 2000;275:27663-70.


The diagnosis, evaluation, and management of von Willebrand disease. NHLBI VWD Expert Panel.
NIH Publication No. 08-5833, 2008.


Laboratory diagnosis of von Willebrand disease.
Hämostaseologie. 2010;30:203–206.

INNOVANCE® D-Dimer Assay

A multicenter evaluation of a new quantitative highly sensitive D-dimer assay for exclusion of venous thromboembolism.
Thromb Haemost. 2008;100:505–512.


Prediction of recurrent venous thromboembolism by endogenous thrombin potential and D-dimer.
Clin Chem. 2008;54:2042-2048.


Different cut-off values of quantitative D-dimer methods to predict the risk of venous thromboembolism recurrence: a post-hoc analysis of the PROLONG study.
Haematologica. 2008 June;93(6):900-907.


The diagnostic management of acute venous thromboembolism during pregnancy: recent advancements and unresolved issues.
Thrombosis Research. 2011;127(Suppl. 3):S13-S16.


An age-adapted approach for the use of D-dimers in the exclusion of deep venous thrombosis.
Am J Hematol. 2009;84:488-491.

ProC® Global Assay*

ProC® Global: a functional screening test that predicts recurrent venous thromboembolism.
Thromb Haemost. 2005;93:600-4.


Laboratory methods in the haemostatic laboratory.
Thromb Haemost. 2006;96:545-6.


Evaluation of ProC® Global assay in women with a history of venous thromboembolism on hormonal therapy.
Thromb Haemost. 2006;96:578-83.


Modification of the ProC® Global assay using dilution of patient plasma in factor V-depleted plasma as a screening assay for factor V Leiden mutation.
Blood Coagul Fibrinolysis. 2001;12:569-576.

INNOVANCE® Antithrombin Assay

Clinical multicenter evaluation of a new FXa-based Antithrombin assay.
Int J Lab Hematol. 2011 Oct;33(5):498-506.

LOCI® Technology

Immunoassays for diagnosis of coagulation disorders.
Hämostaseologie. 2010 Apr.


Coagulation assays based on the Luminescent Oxygen Channeling Immunoassay technology.
Clin Chem Lab Med. 2011;49(5):855-860.


Luminescent oxygen channeling assay (LOCITM): sensitive, broadly applicable homogenous immunoassay method.

Clin Chem. 1996;42(9):1518-1526.

Preanalytical Sample Integrity

Errors in laboratory medicine.
Clin Chem. 2002;48(5):691-698.


Preanalytic error tracking in a laboratory medicine department: results of a 1-year experience.
Clin Chem. 2006;52(7):1442-3.


Preanalytical and postanalytical variables: the leading causes of diagnostic errors in hemostasis?
Sem Thromb Hemost. 2008;34(37):612-634.


Mistakes in a stat laboratory: types and frequency.
Clin Chem. 1997;43(8):1348-1351.


Collection, transport, and processing of blood specimens for testing plasma-based coagulation assays and molecular hemostasis assays.
CLSI Guidelines. Approved Guideline-Fifth Edition; H21-A5.

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