N Latex Cystatin C Assay
Assay for Early Detection of Decline in Renal Function

N Latex Cystatin C Assay

Cystatin C is a nonglycated, low-molecular-weight (13 kDa) protein that is synthesized by all nucleated cells. It is produced at a constant rate regulated by a housekeeping gene.1 Cystatin C is freely filtered by the glomerulus, and there is no tubular secretion or any extrarenal elimination. In addition, cystatin C is not affected by muscle mass, diet, gender, or inflammation.

The relevance of determining cystatin C for diagnosis in CKD is included in the international KDIGO (Kidney Disease Improving Global Outcomes) guidelines.2

No tubular secretion; sensitive in the creatinine-blind range1

  • Higher sensitivity in early disease

Independent of age, sex, and muscle mass1

  • Constant relationship between cystatin C and glomerular filtration rate (GFR) at 1 year of age and older
  • Single reference range: 0.62–1.11 mg/L in children and adults ranging in age from 1 to 78 years
  • Sensitive detection of declining GFR with aging
  • Reliable in patients with spina bifida, paralysis, amputations, etc.

High correlation to GFR reference methods1; high correlation to GFR decline

  • High reliability and accuracy

Increased sensitivity compared to creatinine in liver disease patients3 or by creatinine intake. Cystatin C levels may be influenced by high-dose steroid therapy or thyroid dysfunction.

No analytical interferences known


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1. Newman DJ. Cystatin C. Ann Clin Biochem. 2002;39:89-104.
2. KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Official Journal of the International Society of Nephrology. 2013;3:1-5.
3. Woitas RP, Stoffel-Wagner B, Flommersfeld S, et al. Correlation of serum concentrations of cystatin C and creatinine to inulin clearance in liver cirrhosis. Clin Chem. 2000;46:712–15